Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Attacking Cancer Cells with Hydrogel Nanoparticles

Hydrogel Nanoparticles - An artistic rendering of hydrogel nanoparticles.(Credit: Andrew Lyon)
Hydrogel Nanoparticles - An artistic rendering of hydrogel nanoparticles.(Credit: Andrew Lyon)

Abstract:
One of the difficulties of fighting cancer is that drugs often hit other non-cancerous cells, causing patients to get sick. But what if researchers could sneak cancer-fighting particles into just the cancer cells? Researchers at the Georgia Institute of Technology and the Ovarian Cancer Institute are working on doing just that. In the online journal BMC Cancer they detail a method that uses hydrogels - less than 100 nanometers in size - to sneak a particular type of small interfering RNA(siRNA) into cancer cells. Once in the cell the siRNA turns on the programmed cell death the body uses to kill mutated cells and help traditional chemotherapy do it's job.

Attacking Cancer Cells with Hydrogel Nanoparticles

Atlanta, GA | Posted on February 15th, 2010

Many cancers are characterized by an over abundance of epidermal growth factor receptors (EGFR). When the EGFR level in a cell is elevated it tells the cell to replicate at a rapid rate. It also turns down apoptosis, or programmed cell death.

"With our technique we're inhibiting EGFR's growth, with small interfering RNA. And by inhibiting it's growth, we're increasing the cells's apoptotic function. If we hit the cell with chemotherapy at the same time, we should be able to kill the cancer cells more effectively," said John McDonald, professor at the School of Biology at Georgia Tech and chief research scientist at the Ovarian Cancer Institute.

Small interfering RNA is good at shutting down EGFR production, but once inside the cell siRNA has a limited life span. Keeping it protected inside the hydrogel nanoparticles allows them to get into the cancer cell safely and acts as a protective barrier around them. The hydrogel releases only a small amount of siRNA at a time, ensuring that while some are out in the cancer cell doing their job, reinforcements are held safely inside the nanoparticle until it's time to do their job.

"It's like a Trojan horse," said L. Andrew Lyon, professor in the School of Chemistry and Biochemistry at Georgia Tech. "We've decorated the surface of these hydrogels with a ligand that tricks the cancer cell into taking it up. Once inside, the particles have a slow release profile that leaks out the siRNA over a timescale of days, allowing it to have a therapeutic effect."

Cells use the messenger RNA (mRNA) to generate proteins, which help to keep the cell growing. Once the siRNA enters the cell, it binds to the mRNA and recruits proteins that attack the siRNA-mRNA complex. But the cancer cell's not finished; it keeps generating proteins, so without a continuous supply of siRNA, the cell recovers. Using the hydrogel to slowly release the siRNA allows it to keep up a sustained attack so that it can continue to interrupt the production of proteins.

"We've shown that you can get knock down out to a few days time frame, which could present a clinical window to come in and do multiple treatments in a combination chemotherapy approach," said Lyon.

"The fact that this system is releasing the siRNA slowly, without giving the cell time to immediately recover, gives us much better efficiency at killing the cancer cells with chemotherapy," added McDonald.

Previous techniques have involved using antibodies to knock down the proteins.

"But oftentimes, a mutation may arise in the targeted gene such that the antibody will no longer have the effect it once did, thereby increasing the chance for recurrence," said McDonald.

The team used hydrogels because they're non-toxic, have a relatively slow release rate, and can survive in the body long enough to reach their target.

"It's a well-defined architecture that you're using the intrinsic porosity of that material to load things into, and since our particles are about 98 percent water by volume, there's plenty of internal volume in which to load things," said Lyon.

Currently, the tests have been shown to work in vitro, but the team will be initiating tests in vivo shortly.

####

About Georgia Institute of Technology
The Georgia Institute of Technology is one of the nation's premier research universities. Ranked seventh among U.S. News & World Report's top public universities, Georgia Tech's more than 20,000 students are enrolled in its Colleges of Architecture, Computing, Engineering, Liberal Arts, Management and Sciences. Tech is among the nation's top producers of women and minority engineers. The Institute offers research opportunities to both undergraduate and graduate students and is home to more than 100 interdisciplinary units plus the Georgia Tech Research Institute.

For more information, please click here

Contacts:
David Terraso
Communications and Marketing
404-385-2966

Copyright © Georgia Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

East China University of Science and Technology Purchases Nanonex Advanced Nanoimprint Tool NX-B200 July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

Nanomedicine

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Announcements

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

Nanobiotechnology

Harris & Harris Group Invests in Unique NYC Biotech Accelerator July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

Alliances/Partnerships/Distributorships

Nature inspires a greener way to make colorful plastics July 30th, 2014

SouthWest NanoTechnologies Names NanoSperse as A SWeNT Certified Compounder July 29th, 2014

ACS Biomaterials Science & Engineering™: Brand-new journal names editor July 29th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE