Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Delivering drugs on time and on target

Professor Vladimir Torchilin is using nanotechnology to make drugs more effective.  Photo by Lauren McFalls.
Professor Vladimir Torchilin is using nanotechnology to make drugs more effective. Photo by Lauren McFalls.

Abstract:
Vladimir Torchilin, distinguished professor of pharmaceutical sciences at Northeastern University, recently received a $1.36 million grant from the National Institutes of Health's Cancer Institute to examine a new, nanotechnology-based method of drug development.

Delivering drugs on time and on target

Boston, MA | Posted on February 5th, 2010

Coupling pharmaceutical nanotechnology with a new drug-coating process, this novel technique has the potential to make water-insoluble drugs effective and increase the amount of active drug ingredients in the medication.

"The technique we propose could improve the function of existing drugs and could also produce new therapeutic options for many diseases," said Torchilin, who is the director of Northeastern's Center for Pharmaceutical Biotechnology and Nanomedicine, and the principal investigator on the grant.

Water-insoluble drugs have a low efficacy rate because they are poorly absorbed in the body, and can cause blood vessel blockages if injected. These properties have hindered the development of water-insoluble drugs as viable treatment options, leaving thousands of promising therapeutics on the shelf.

To counter these properties, Torchilin together with his collaborators from Louisiana Tech University has applied a layer-by-layer method of coating drug nanoparticles with certain biocompatible polymeric materials. These materials prevent drug precipitation or aggregation into larger particles, enabling the drugs to be injected into the body and travel precisely to the disease target. Additionally, more of the drug's active ingredients reach the target, and can be programmed to release at a specific time.

Torchilin's research on nanocarriers has played a major role in the field of nanomedicine, which is expected to be a $15 trillion industry by 2015. Torchilin likens nanocarriers to trains, delivering precise amounts of drugs to a specific place at a specific time. While en route to their destination ó diseased cells ó nanocarriers envelop the drugs like a train's boxcars, preventing them from killing healthy cells.

"Cancer drugs need to be delivered inside the cell in order to kill cancer cells, and nanocarriers make that possible," said Torchilin. "There are many potential applications for insoluble drugs, and this new technology will help us explore these options."

The research, now being conducted in vitro (with target cells in a controlled environment), will eventually be tested in mice to investigate its' potential application in humans.

Torchilin is working with Yuri Lvov, professor of micro and nanosystems at Louisiana Tech University.

For more information about Professor Torchilin's research, please visit www.northeastern.edu/bouve/faculty/torchilin_v.html

####

About Northeastern University
Founded in 1898, Northeastern is a private research university located in the heart of Boston, and a leader in experiential learning, urban engagement, and in interdisciplinary research that meets global and societal needs. Our broad mix of experience-based education programs ó our signature cooperative education program, student research, service learning, and global learning ó build the connections and confidence that enable students to transform their lives. The university offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in seven undergraduate colleges, seven graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Jenny Catherine Eriksen
617-373-2802

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Possible Futures

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Nanomedicine

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

Announcements

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Particle zoo in a quantum computer: First experimental quantum simulation of particle physics phenomena June 23rd, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Nanobiotechnology

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Tailored DNA shifts electrons into the 'fast lane': DNA nanowire improved by altering sequences June 22nd, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

Alliances/Trade associations/Partnerships/Distributorships

FEI and University of Liverpool Announce QEMSCAN Research Initiative: University of Liverpool will utilize FEIís QEMSCAN technology to gain a better insight into oil and gas reserves & potentially change the approach to evaluating them June 22nd, 2016

French Research Team Helps Extend MRI Detection of Diseases & Lower Health-Care Costs: CEA, INSERM and G2ELab Brings Grenoble Regionís Expertise In Advanced Medicine & Magnetism Applications to H2020 IDentIFY Project June 21st, 2016

Research showing why hierarchy exists will aid the development of artificial intelligence June 13th, 2016

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic