Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Delivering drugs on time and on target

Professor Vladimir Torchilin is using nanotechnology to make drugs more effective.  Photo by Lauren McFalls.
Professor Vladimir Torchilin is using nanotechnology to make drugs more effective. Photo by Lauren McFalls.

Abstract:
Vladimir Torchilin, distinguished professor of pharmaceutical sciences at Northeastern University, recently received a $1.36 million grant from the National Institutes of Health's Cancer Institute to examine a new, nanotechnology-based method of drug development.

Delivering drugs on time and on target

Boston, MA | Posted on February 5th, 2010

Coupling pharmaceutical nanotechnology with a new drug-coating process, this novel technique has the potential to make water-insoluble drugs effective and increase the amount of active drug ingredients in the medication.

"The technique we propose could improve the function of existing drugs and could also produce new therapeutic options for many diseases," said Torchilin, who is the director of Northeastern's Center for Pharmaceutical Biotechnology and Nanomedicine, and the principal investigator on the grant.

Water-insoluble drugs have a low efficacy rate because they are poorly absorbed in the body, and can cause blood vessel blockages if injected. These properties have hindered the development of water-insoluble drugs as viable treatment options, leaving thousands of promising therapeutics on the shelf.

To counter these properties, Torchilin together with his collaborators from Louisiana Tech University has applied a layer-by-layer method of coating drug nanoparticles with certain biocompatible polymeric materials. These materials prevent drug precipitation or aggregation into larger particles, enabling the drugs to be injected into the body and travel precisely to the disease target. Additionally, more of the drug's active ingredients reach the target, and can be programmed to release at a specific time.

Torchilin's research on nanocarriers has played a major role in the field of nanomedicine, which is expected to be a $15 trillion industry by 2015. Torchilin likens nanocarriers to trains, delivering precise amounts of drugs to a specific place at a specific time. While en route to their destination — diseased cells — nanocarriers envelop the drugs like a train's boxcars, preventing them from killing healthy cells.

"Cancer drugs need to be delivered inside the cell in order to kill cancer cells, and nanocarriers make that possible," said Torchilin. "There are many potential applications for insoluble drugs, and this new technology will help us explore these options."

The research, now being conducted in vitro (with target cells in a controlled environment), will eventually be tested in mice to investigate its' potential application in humans.

Torchilin is working with Yuri Lvov, professor of micro and nanosystems at Louisiana Tech University.

For more information about Professor Torchilin's research, please visit www.northeastern.edu/bouve/faculty/torchilin_v.html

####

About Northeastern University
Founded in 1898, Northeastern is a private research university located in the heart of Boston, and a leader in experiential learning, urban engagement, and in interdisciplinary research that meets global and societal needs. Our broad mix of experience-based education programs — our signature cooperative education program, student research, service learning, and global learning — build the connections and confidence that enable students to transform their lives. The university offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in seven undergraduate colleges, seven graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Jenny Catherine Eriksen
617-373-2802

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Possible Futures

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

The "Tipping Point" February 12th, 2014

Nanomedicine

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Announcements

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

IDTechEx Printed Electronics Europe 2014 Award Winners April 1st, 2014

Dais Analytic Wins SBIR Grant: Dais Analytic Receives US Army Small Business Innovation Research Grant to Further Its Demonstrated Successes in Cleaning Most Forms of Wastewater March 28th, 2014

Scientists develop world’s first light-activated antimicrobial surface that also works in the dark March 24th, 2014

Nanobiotechnology

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Alliances/Partnerships/Distributorships

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Peer Reviewed and Approved for Science by the the Washington Academy of Sciences April 3rd, 2014

New JEOL-Nikon MiXcroscopy Correlative Imaging Solution March 27th, 2014

Quantum Dots Take Center Stage at Inaugural Event: QD Vision Co-Founder and CTO Dr. Seth Coe-Sullivan to Chair First Quantum Dots Forum, March 26, 2014, San Diego, CA March 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE