Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > A 'fountain of youth' for stem cells?

Abstract:
Researchers from the University of Hong Kong and the Massachusetts Institute of Technology have published a study in the current issue of Cell Transplantation (18:9), now freely available on line at www.ingentaconnect.com/content/cog/ct, that explores ways to successfully keep stem cells "forever young" during implantation by slowing their growth, differentiation and proliferation.

A 'fountain of youth' for stem cells?

Tampa, FL | Posted on December 29th, 2009

"The successful storage and implantation of stem cells poses significant challenges for tissue engineering in the nervous system, challenges in addition to those inherent to neural regeneration," said Dr. Ellis-Behnke, corresponding author. "There is a need for creating an environment that can regulate cell activity by delaying cell proliferation, proliferation and maturation. Nanoscaffolds can play a central role in organ regeneration as they act as templates and guides for cell proliferation, differentiation and tissue growth. It is also important to protect these fragile cells from the harsh environment in which they are transplanted."

According to Dr. Ellis-Behnke, advancements in nanotechnology offer a "new era" in tissue and organ reconstruction. Thus, finding the right nano-sized scaffold could be beneficial, so the research team developed a "self-assembling nanofiber scaffold" (SAPNS), a nanotechnology application to use for implanting young cells.

"Fine control of the nanodomain will allow for increased targeting of cell placement and therapeutic delivery amplified by cell encapsulation and implantation," explained Dr. Ellis-Behnke.

The research team created the scaffold to provide a substrate for cell adhesion and migration and to influence the survival of transplanted cells or the invasion of cells from surrounding tissue. The SAPNS they developed appear to slow the growth rate and differentiation of the cells, allowing the cells time to acclimate to their new environment.

"That delay is very important when the immune system tries attacking cells when they are placed in vivo," he further explained.

By manipulating both cell density and SAPNS concentration, the researchers were able to control the nanoenvironment surrounding PC 12 cells (a cell line developed from transplantable rat cells that respond to nerve growth factor), Schwann cells (glial cells that keep peripheral nerve fibers alive) and neural precursor cells (NPCs) and also control their proliferation, elongation, differentiation and maturation in vitro. They extended the method to living animals with implants in the brain and spinal cord.

The researchers concluded that the use of a combination of SAPNS and young cells eliminated the need for immuno-suppressants when cells were implanted in the central nervous system.

"Implanted stem cells are adversely susceptible to their new environment and quickly get old, but this study suggests a solution to conquer this problem," said Prof. Shinn-Zong Lin, professor of Neurosurgery at China University Medical Hospital, Taiwan and Chairman of the Pan Pacific Symposium on Stem Cell Research where part of this work was first presented. "The self-assembling nanofiber scaffold (SAPNS) provides a niche for the encapsulated stem cells by slowing down their growth, differentiation and proliferation, as well as potentially minimizing the immune response, thus enhancing the survival rate of the implanted stem cells. This allows the implanted stem cells to "stay forever young" and extend their neurites to reach distant targets, thereby re-establishing the neural circuits

This combination of stem cells and SAPNS technologies gives a new hope for building up younger neural circuit in the central neural system."

####

Contacts:
Rutlege Ellis-Behnke
Dept. of Anatomy
The University of Hong Kong
Li Ka Shing Faculty of Medicine
1/F Laboratory Block
21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Tel: 852-2819-9205
fax: 852-2817-0857


Department of Brain & Cognitive Sciences
Massachusetts Institute of Technology 43 Vassar Street, Cambridge, MA 02139 Tel: (ofc) 1-617-253-4556
(cell) 1-857-212-9589

Copyright © Eurekalert

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Researchers Synthesize Stable Ceramic Nanopowders at Room Temperature September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Self Assembly

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Molecular self-assembly controls graphene-edge configuration September 10th, 2014

Rice chemist wins rare NSF Special Creativity Award: Grant extension will bolster Zubarev's effort to produce gold nanorods September 8th, 2014

Nanomedicine

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Announcements

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Nanobiotechnology

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

CiQUS researchers design an artificial nose to detect DNA differentiation with single nucleotide resolution September 18th, 2014

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE