Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > A 'fountain of youth' for stem cells?

Abstract:
Researchers from the University of Hong Kong and the Massachusetts Institute of Technology have published a study in the current issue of Cell Transplantation (18:9), now freely available on line at www.ingentaconnect.com/content/cog/ct, that explores ways to successfully keep stem cells "forever young" during implantation by slowing their growth, differentiation and proliferation.

A 'fountain of youth' for stem cells?

Tampa, FL | Posted on December 29th, 2009

"The successful storage and implantation of stem cells poses significant challenges for tissue engineering in the nervous system, challenges in addition to those inherent to neural regeneration," said Dr. Ellis-Behnke, corresponding author. "There is a need for creating an environment that can regulate cell activity by delaying cell proliferation, proliferation and maturation. Nanoscaffolds can play a central role in organ regeneration as they act as templates and guides for cell proliferation, differentiation and tissue growth. It is also important to protect these fragile cells from the harsh environment in which they are transplanted."

According to Dr. Ellis-Behnke, advancements in nanotechnology offer a "new era" in tissue and organ reconstruction. Thus, finding the right nano-sized scaffold could be beneficial, so the research team developed a "self-assembling nanofiber scaffold" (SAPNS), a nanotechnology application to use for implanting young cells.

"Fine control of the nanodomain will allow for increased targeting of cell placement and therapeutic delivery amplified by cell encapsulation and implantation," explained Dr. Ellis-Behnke.

The research team created the scaffold to provide a substrate for cell adhesion and migration and to influence the survival of transplanted cells or the invasion of cells from surrounding tissue. The SAPNS they developed appear to slow the growth rate and differentiation of the cells, allowing the cells time to acclimate to their new environment.

"That delay is very important when the immune system tries attacking cells when they are placed in vivo," he further explained.

By manipulating both cell density and SAPNS concentration, the researchers were able to control the nanoenvironment surrounding PC 12 cells (a cell line developed from transplantable rat cells that respond to nerve growth factor), Schwann cells (glial cells that keep peripheral nerve fibers alive) and neural precursor cells (NPCs) and also control their proliferation, elongation, differentiation and maturation in vitro. They extended the method to living animals with implants in the brain and spinal cord.

The researchers concluded that the use of a combination of SAPNS and young cells eliminated the need for immuno-suppressants when cells were implanted in the central nervous system.

"Implanted stem cells are adversely susceptible to their new environment and quickly get old, but this study suggests a solution to conquer this problem," said Prof. Shinn-Zong Lin, professor of Neurosurgery at China University Medical Hospital, Taiwan and Chairman of the Pan Pacific Symposium on Stem Cell Research where part of this work was first presented. "The self-assembling nanofiber scaffold (SAPNS) provides a niche for the encapsulated stem cells by slowing down their growth, differentiation and proliferation, as well as potentially minimizing the immune response, thus enhancing the survival rate of the implanted stem cells. This allows the implanted stem cells to "stay forever young" and extend their neurites to reach distant targets, thereby re-establishing the neural circuits

This combination of stem cells and SAPNS technologies gives a new hope for building up younger neural circuit in the central neural system."

####

Contacts:
Rutlege Ellis-Behnke
Dept. of Anatomy
The University of Hong Kong
Li Ka Shing Faculty of Medicine
1/F Laboratory Block
21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Tel: 852-2819-9205
fax: 852-2817-0857


Department of Brain & Cognitive Sciences
Massachusetts Institute of Technology 43 Vassar Street, Cambridge, MA 02139 Tel: (ofc) 1-617-253-4556
(cell) 1-857-212-9589

Copyright © Eurekalert

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Possible Futures

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Strength of hair inspires new materials for body armor January 18th, 2017

Self Assembly

Self-assembling particles brighten future of LED lighting January 18th, 2017

Manchester scientists tie the tightest knot ever achieved January 13th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Researchers fabricate high performance Cu(OH)2 supercapacitor electrodes December 29th, 2016

Nanomedicine

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Announcements

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Nanobiotechnology

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project