- About Us
- Nano-Social Network
- Nano Consulting
- My Account
|The near-infrared laser pathway into the cell culture plate, traced by visible laser for photo. photo credit: Rod Rolle|
Researchers at UC Santa Barbara have developed a new way to deliver drugs into cancer cells by exposing them briefly to a non-harmful laser. Their results are published in a recent article in ACS NANO, a journal of the American Chemical Society.
"This entirely novel tool will allow biologists to investigate how genes function by providing them with temporal and spatial control over when a gene is turned on or off," explained Norbert Reich, senior author and a professor in the Department of Chemistry and Biochemistry at UCSB. "In a nutshell, what we describe is the ability to control genes in cells -- and we are working on doing this in animals -- simply by briefly exposing them to a non-harmful laser."
The scientists used cancer cells from mice, and grew them in culture. They then introduced gold nanoshells, with a peptide-lipid coating, that encapsulated "silencing ribonucleic acid" (siRNA), which was the drug that was taken up by the cells. Next, they exposed the cells to a non-harmful infrared laser.
"A major technical hurdle is how to combine multiple biochemical components into a compact nanoparticle which may be taken up by cells and exist stably until the release is desired," said Gary Braun, first author and a graduate student in UCSB's Department of Chemistry and Biochemistry. "Laser-controlled release is a convenient and powerful tool, allowing precise dosing of particular cells within a group. The use of biologically friendly tissue penetration with near-infrared light is the ideal for extending this capability into larger biological systems such as tissues and animals."
The authors demonstrated, for the first time, the delivery of a potent siRNA cargo inside mammalian cancer cells, released by exposing the internalized nanoparticles for several seconds to a pulsed near-infrared laser tuned for peak absorption with a specific spatial pattern. The technique can be expanded to deliver numerous drug molecules against diverse biological targets.
The additional collaborating authors on the paper are Alessia Pallaoro, also of UCSB's Department of Chemistry and Biochemistry; Guohui Wu and Joseph A. Zasadzinski, of UCSB's Department of Chemical Engineering; Dimitris Missirlis, of UCSB's College of Engineering, and Matthew Tirrell, former dean of UCSB's College of Engineering and now at UC Berkeley.
UCSB is one of only 62 institutions elected to membership in the prestigious Association of American Universities. And the Newsweek guide to America's best colleges has named UCSB one of the country's "hottest colleges" twice in the past five years.
For more information, please click here
Copyright © UCSBIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
ATTOPSEMI Technology Joins FDXcelerator Program to Deliver Advanced Non-Volatile Memory IP to GLOBALFOUNDRIES 22 FDX® Technology Platform: Leading-edge I-fuse™ brings higher reliability, smaller cell size and ease of programmability for consumer, automotive, and IoT applications March 27th, 2017
Leti and HORIBA Scientific to Host Webinar on Ultrafast Characterization Tool: Plasma Profiling Time-of-Flight Mass Spectrometer Tool Cuts Optimization Time In Layer Deposition and Fabrication of Wide Range of Applications March 27th, 2017
AIM Photonics Welcomes Coventor as Newest Member: US-Backed Initiative Taps Process Modeling Specialist to Enable Manufacturing of High-Yield, High-Performance Integrated Photonic Designs March 16th, 2017