Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Synthetic Red Blood Cells Developed

Biocompatible synthetic red blood cells (sRBCs) synthesized by the UCSB team, where the shell is composed of alternate layers of hemoglobin and BSA. (Scale bar, 5 microns)
Biocompatible synthetic red blood cells (sRBCs) synthesized by the UCSB team, where the shell is composed of alternate layers of hemoglobin and BSA. (Scale bar, 5 microns)

Abstract:
Soft and synthetic red-blood-cell-like particles carry oxygen, drugs, and more…

Synthetic Red Blood Cells Developed

Santa Barbara, CA | Posted on December 28th, 2009

Scientists at UC Santa Barbara, in collaboration with scientists at University of Michigan, have developed synthetic particles that closely mimic the characteristics and key functions of natural red blood cells, including softness, flexibility, and the ability to carry oxygen.

The primary function of natural red blood cells is to carry oxygen, and the synthetic red blood cells (sRBCs) do that very well, retaining 90% of their oxygen-binding capacity after a week. The sRBCs also, however, have been shown to deliver therapeutic drugs effectively and with controlled release, and to carry well-distributed contrast agents for enhanced resolution in diagnostic imaging.

"This ability to create flexible biomimetic carriers for therapeutic and diagnostic agents really opens up a whole new realm of possibilities in drug delivery and similar applications," noted UCSB chemical engineering professor Samir Mitragotri. "We know that we can further engineer sRBCs to carry additional therapeutic agents, both encapsulated in the sRBC and on its surface."

Mitragotri, his research group, and their collaborators from the University of Michigan succeeded in synthesizing the particles by creating a polymer doughnut-shaped template, coating the template with up to nine layers of hemoglobin and other proteins, then removing the core template. The resulting particles have the same size and flexibility, and can carry as much oxygen, as natural red blood cells. The flexibility, absent in "conventional" polymer-based biomaterials developed as carriers for therapeutic and diagnostic agents, gives the sRBCs the ability to flow through channels smaller than their resting diameter, stretching in response to flow and regaining their discoidal shape upon exiting the capillary, just as their natural counterparts do.

In addition to synthesizing particles that mimic the shape and properties of healthy RBCs, the technique described in the paper can also be used to develop particles that mimic the shape and properties of diseased cells, such as those found in sickle-cell anemia and hereditary eliptocytosis. The availability of such synthetic diseased cells is expected to lead to greater understanding of how those diseases and others affect RBCs.

The discovery is described in the current online edition of Proceedings of the National Academy of Science, and will be published in the print version of the journal in the near future. UCSB graduate student Nishti Doshi was the lead author of the paper; former post-doctoral researcher Alisar Zahr (now at Harvard Medical School's Schepens Eye Research Institute), Mitragotri, and their University of Michigan collaborators Srijanani Bhaskar and professor Joerg Lahann were co-authors.

####

About College of Engineering at UC Santa Barbara
The College of Engineering at UC Santa Barbara is a global leader in bioengineering, chemical and computational engineering, materials science, nanotechnology and physics. UCSB boasts five Nobel Laureates (four in sciences and engineering) and one winner of the prestigious international Millennium Technology Prize. Our students, professors and staff thrive in a uniquely-successful interdisciplinary and entrepreneurial culture. Our professors' research is among the most cited by their peers, evidence of the significance and relevance of their work.

For more information, please click here

Contacts:
Media Contact
Tony Rairden

805.893.4301

Copyright © College of Engineering at UC Santa Barbara

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New exotic phenomena seen in photonic crystals: Researchers observe, for the first time, topological effects unique to an “open” system January 12th, 2018

'Decorated' stem cells could offer targeted heart repair January 11th, 2018

Nanotube fibers in a jiffy: Rice University lab makes short nanotube samples by hand to dramatically cut production time January 11th, 2018

IBM Breaks Records to Top U.S. Patent List for 25th Consecutive Year: IBM Inventors Receive Record 9,043 Patents in 2017 in Areas such as Artificial Intelligence, Cloud, Blockchain, Cybersecurity and Quantum Computing January 11th, 2018

Synthetic Biology

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

Living computers: RNA circuits transform cells into nanodevices July 27th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Nanomedicine

'Decorated' stem cells could offer targeted heart repair January 11th, 2018

Rice University lab modifies nanoscale virus to deliver peptide drugs to cells, tissues January 8th, 2018

SNUH team develops new nanomaterial for thermal cancer therapy January 5th, 2018

Novel nanomedicine inhibits progression of pancreatic cancer in mice: Survival rates in pancreatic cancer linked to inverse correlation between specific oncogene and tumor suppressant, Tel Aviv University researchers say January 3rd, 2018

Announcements

New exotic phenomena seen in photonic crystals: Researchers observe, for the first time, topological effects unique to an “open” system January 12th, 2018

'Decorated' stem cells could offer targeted heart repair January 11th, 2018

Nanotube fibers in a jiffy: Rice University lab makes short nanotube samples by hand to dramatically cut production time January 11th, 2018

IBM Breaks Records to Top U.S. Patent List for 25th Consecutive Year: IBM Inventors Receive Record 9,043 Patents in 2017 in Areas such as Artificial Intelligence, Cloud, Blockchain, Cybersecurity and Quantum Computing January 11th, 2018

Nanobiotechnology

'Decorated' stem cells could offer targeted heart repair January 11th, 2018

Rice University lab modifies nanoscale virus to deliver peptide drugs to cells, tissues January 8th, 2018

Novel nanomedicine inhibits progression of pancreatic cancer in mice: Survival rates in pancreatic cancer linked to inverse correlation between specific oncogene and tumor suppressant, Tel Aviv University researchers say January 3rd, 2018

Development of a nanowire device to detect cancer with a urine test December 26th, 2017

Alliances/Trade associations/Partnerships/Distributorships

New era in high field superconducting magnets – opening new frontiers in science, nanotechnology and materials discovery January 9th, 2018

Leti Field Trials Demonstrate New Multicarrier Waveform for Rural, Maritime Broadband Radio: Field Trial in Orkney Islands Used New Filtered Multicarrier Waveform at 700MHz Band with Flexible Bandwidth Usage (Fragmented and Continuous Spectrum) December 18th, 2017

A new product to help combat mouldy walls, thanks to technology developed at the ICN2 December 14th, 2017

JPK Instruments announce partnership with Swiss company, Cytosurge AG. The partnership makes Cytosurge’s FluidFM® technology available on the JPK NanoWizard® AFM platform December 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project