Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New insight in nerve cell communication

Right: Brain-lipid vesicles. Smaller "dots" indicate smaller vesicles. Left: BAR domain protein. The intensity of the dot indicates the amount of BAR bound to the vesicle. The smaller the vesicle, the more curved membrane, and the more binding of BAR.

Credit: Dimitrios Stamou
Right: Brain-lipid vesicles. Smaller "dots" indicate smaller vesicles. Left: BAR domain protein. The intensity of the dot indicates the amount of BAR bound to the vesicle. The smaller the vesicle, the more curved membrane, and the more binding of BAR. Credit: Dimitrios Stamou

Abstract:
Communication between nerve cells is vital for our bodies to function. Part of this communication happens through vesicles containing signalling molecules called neurotransmitters. The vesicle fuses with the nerve cell membrane; the neurotransmitters are released and quickly recorded by the next nerve cell. It is crucial that new vesicles constantly are produced for the nerve cell communication continuously to take place. If parts of this communication do not work, it leads to nerve pain like phantom pain following amputation.

New insight in nerve cell communication

Copenhagen | Posted on December 22nd, 2009

New discoveries on a nanoscale

- In patients with nerve pain, part of the pathological picture is a defect in a protein domain we call BAR. We have studied how BAR binds to small membrane vesicles of different size. We expect that the new knowledge can be used to combat nerve pain in the future, explains Associate Professor Dimitrios Stamou, Bio-Nanotechnology Laboratory, Nano-Science Center and the Department of Neuroscience and Pharmacology. Dimitrios Stamou has led the work.

- We have used nanotechnology techniques, which give us the unique opportunity to study the binding of proteins to individual vesicles. Earlier studies have been performed in solutions where you measure a large number of vesicles and proteins at a time. This gives an average value of binding and "masks out" a large number of important information that we can retrieve by measurements on single vesicles, says Dimitrios Stamou.

Error in communication

More and more studies - this study included, show that the curvature of the membrane is absolutely central to the binding of proteins to cell membranes - the greater the curvature, the greater the binding. This also applies to nerve cells in the brain. It therefore provides an important insight for the overall understanding of how nerve cells communicate with each other and for treating diseases where the communication has failed.

- To our great surprise we find that BAR binds to the membrane vesicles via small cracks in the vesicle membrane. We had expected that BAR bound to the small round membrane vesicles both because of its banana shaped structure, which fits with the shape of the vesicle, and by means of an attraction between "the banana's" positive surface and vesicle's negative surface. But instead, it is the hydrophobic part of BAR that is involved in binding, explains Dimitrios Stamou.

####

About University of Copenhagen
With over 37,000 students and more than 7,000 employees, the University of Copenhagen is the largest institution of research and education in Denmark.

For more information, please click here

Contacts:
Dimitrios Stamou

454-116-0468

Communication Officer
Gitte Frandsen

Tel.: +45 28 75 04 58

Copyright © University of Copenhagen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Quantum states in a nano-object manipulated using a mechanical system August 3rd, 2015

Nanoparticles used to breach mucus barrier in lungs: Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases August 3rd, 2015

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Possible Futures

Nanofiltration Membrane Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanozirconia Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Self-Healing Nano Anti-rust Coatings Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nano Spray Instrument Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanomedicine

Nanoparticles used to breach mucus barrier in lungs: Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases August 3rd, 2015

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors August 1st, 2015

Announcements

Quantum states in a nano-object manipulated using a mechanical system August 3rd, 2015

Nanoparticles used to breach mucus barrier in lungs: Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases August 3rd, 2015

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Nanobiotechnology

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

New computer model could explain how simple molecules took first step toward life: Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules July 28th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project