Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Molecular Freight

A valuable cargo: Polysaccharides (-1,3-glucans) act as a host compound to various nanomaterial cargoes such as single-walled carbon nanotubes. The cargo packed in the host container is transported on the rail (F-actin) by wheels and a molecular motor (myosin) attached to the container (see picture). This artificial system is inspired by a container transportation system based on the motion of vesicles in biological cells. Copyright  Wiley InterScience
A valuable cargo: Polysaccharides (-1,3-glucans) act as a host compound to various nanomaterial cargoes such as single-walled carbon nanotubes. The cargo packed in the host container is transported on the rail (F-actin) by wheels and a molecular motor (myosin) attached to the container (see picture). This artificial system is inspired by a container transportation system based on the motion of vesicles in biological cells. Copyright Wiley InterScience

Abstract:
Synthetic nanoscale transport system modeled on nature

Molecular Freight

Japan | Posted on December 21st, 2009

Just like our roads, there is a lot of traffic within the cells in our bodies, because cell components, messenger molecules, and enzymes must also be brought to the right places in the cell. One of these transportation systems functions like a kind of railway: a system of molecular tracks is used to transport vesicles and their contents to their target destinations. In imitation of this natural "cargo transport", Japanese researchers have developed a synthetic molecular transport system. The scientists, led by Youichi Tsuchiya and Seiji Shinkai, report in the journal Angewandte Chemie that this could form the basis for the development of a method for transporting therapeutic genes into cell nuclei.

The cellular rail system uses actin filaments for tracks. Actin filaments are strong strands of protein that form a network inside a cell. Acting as both motor proteins and wheels are myosin molecules, which move along the tracks. The vesicle being transported hangs on to the tail end of the myosin. The myosin head consists of ATPase, an enzyme that degrades ATP. ATP is cellular fuel; its decomposition releases energy. In the process of splitting the ATP, the angle of the myosin head attached to the actin filament changes, which causes the myosin to move along the filament like a wheel on a track, bringing its cargo along for the ride.

The researchers also incorporated actin, myosin, and ATP as components for their synthetic transport system. For their container, they chose schizophyllan, a triple-stranded helical polysaccharide from fungi. In certain solvents the helix unravels; when placed back in water, the polysaccharide twists back up into a helix. In this process, it can wrap around large molecules or nanoparticles, packaging them up. In their study, the researchers loaded these molecular containers with carbon nanotubes. They used cobalt ions to dock on several myosin units, and these wheels did indeed move the tiny freight train along the actin track. With an average speed of about 95 nm/s, the freight cars crossed the amazing distance of about 5 m.

Transport along cellular actin tracks always moves in only one direction. The filaments are bound to each other at junctions, creating a transportation network that also allows for changes in direction within the cell. The synthetic molecular freight trains can also change from one filament to another at junctions in the network. Because the direction of the actin track leads into the cell nucleus, the artificial transport system may be useful in gene therapy, because it could wrap up the therapeutic genes and carry them into the cellular nucleus.


Author: Seiji Shinkai, ISIT, Fukuoka (Japan),

Title: A Polysaccharide-Based Container Transportation System Powered by Molecular Motors

Angewandte Chemie International Edition, Permalink: dx.doi.org/10.1002/anie.200904909

####

For more information, please click here

Contacts:
Editorial office


Amy Molnar (US)


Jennifer Beal (UK)


Alina Boey (Asia)

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Silicon Valley-Based Foresight Valuation Launches STR-IP, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Nanotubes/Buckyballs

A sponge-like molecular cage for purification of fullerenes December 15th, 2014

'Trojan horse' proteins used to target hard-to-reach cancers: Scientists at Brunel University London have found a way of targeting hard-to-reach cancers and degenerative diseases using nanoparticles, but without causing the damaging side effects the treatment normally brings December 11th, 2014

Detecting gases wirelessly and cheaply: New sensor can transmit information on hazardous chemicals or food spoilage to a smartphone December 8th, 2014

Green meets nano: Scientists at TU Darmstadt create multifunctional nanotubes using nontoxic materials December 3rd, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Announcements

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Silicon Valley-Based Foresight Valuation Launches STR-IP, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Nanobiotechnology

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE