Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Switchable Nanostructures Made with DNA

Using DNA to assemble nanoclusters: (a) (1) DNA linker strands (squiggly lines) are used to attach DNA-coated nanoparticles to a surface. (2) Linker strands are attached to the top side of the nanoparticle. (b) (3a) A nanoparticle of a second type with complementary DNA encoding recognizes the exposed linker strands and attaches to the surface-anchored nanoparticle. (4a and 5a) The assembled structure is released from the surface support, resulting in a two-particle, dimer cluster. (c) (3b) Alternatively, the immobilized particles produced in step (a) are released from the surface, leaving the opposite-side linker strands free to bind with multiple particles (4b) to form asymmetric "Janus" clusters.
Using DNA to assemble nanoclusters: (a) (1) DNA linker strands (squiggly lines) are used to attach DNA-coated nanoparticles to a surface. (2) Linker strands are attached to the top side of the nanoparticle. (b) (3a) A nanoparticle of a second type with complementary DNA encoding recognizes the exposed linker strands and attaches to the surface-anchored nanoparticle. (4a and 5a) The assembled structure is released from the surface support, resulting in a two-particle, dimer cluster. (c) (3b) Alternatively, the immobilized particles produced in step (a) are released from the surface, leaving the opposite-side linker strands free to bind with multiple particles (4b) to form asymmetric "Janus" clusters.

Abstract:
Opens possibility of responsive 'nanomachines' for applications in energy and data storage

Switchable Nanostructures Made with DNA

Upton, NY | Posted on December 20th, 2009

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have found a new way to use a synthetic form of DNA to control the assembly of nanoparticles - this time resulting in switchable, three-dimensional and small-cluster structures that might be useful, for example, as biosensors, in solar cells, and as new materials for data storage. The work is described in Nature Nanotechnology, published online December 20, 2009.

The Brookhaven team, led by physicist Oleg Gang, has been refining techniques to use strands of artificial DNA as a highly specific kind of Velcro or glue to link up nanoparticles [see: www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=921]. Such DNA-based self-assembly holds promise for the rational design of a range of new materials for applications in molecular separation, electronics, energy conversion, and other fields. But none of these structures has had the ability to change in a programmable manner in response to molecular stimuli - until now.

"Now we're using a special type of DNA-linking device - a kind of 'smart glue' - that affects how the particles connect to make structures that are switchable between different configurations," says Gang. This reliable, reversible switching could be used to regulate functional properties - for example, a material's fluorescence and energy transfer properties - to make new materials that are responsive to changing conditions, or to alter their functions on demand.

Such responsiveness to changes in environmental conditions and the ability to adopt new forms are hallmarks of living systems. In that way, these new nanomaterials more closely mimic biological systems than any previous nanostructures. Though far from any form of truly "artificial life," these materials could lead to the design of nanoscale machines that, at a very simple level, mimic cellular processes such as converting sunlight into useful energy, or sensing the presence of other molecules. Responsive materials would also have benefits in the field of optics or to produce regulated porous materials for molecular separations, Gang says.

The scientists achieved the goal of responsiveness by creating structures where the distance between nanoparticles could be carefully controlled with nanometer accuracy.

"Many physical characteristics of nanomaterials, such as optical and magnetic properties, are strongly dependent on the distance between nanoparticles," Gang explains.

In their previous studies, the scientists used single strands of DNA attached to individual nanoparticles as linker molecules. When the free ends of these DNA strands had complementary genetic code, they would bind to attach the particles. Constraining the interactions by anchoring some of the particles on a surface allowed the scientists to reliably form a variety of structures from two-particle clusters (called dimers) to more complex 3-D nanoparticle crystals.

In the new work, the scientists have added more complicated, double-stranded DNA structures. Unlike the single strands, which coil in uncontrollable ways, these double-stranded structures are more rigid and therefore constrain the interparticle distances.

Additionally, some of the strands making up the double-stranded DNA molecules have complicated structures such as loops, which pull the bound particles closer together than when both strands are exactly parallel. By varying the type of DNA device, between looped and unlooped strands, and measuring the interparticle distances using precision techniques at Brookhaven's National Synchrotron Light Source (NSLS) and at the Center for Functional Nanomaterials (CFN), the scientists demonstrated that they could effectively control the distance between the particles and switch the system from one state to another at will.

The approach resulted in two-configuration, switchable systems both in dimers and nanocrystals, with a distance change of about 6 nanometers - about 25 percent of the interparticle distance. By comparing kinetics in the two systems, they found that the switching between states is faster in the simpler, two-particle system. The dimers also retain their ability to return to their initial state more precisely than the 3-D crystals, suggesting that molecular crowding may be an issue to further investigate in the 3-D materials.

"Our hope is that the ability to induce post-assembly reorganization of these structures by adding DNA or other molecules as external stimuli, and our ability to observe these changes with nanometer resolution, will help us understand these processes and find ways to apply them in new kinds of nanomachinery in which the system's functionality is determined by the nanoparticles and their relative organization," says Gang.

Future studies will make use of precise imaging capabilities, such as advanced electron microscopy tools at the CFN and higher-resolution x-ray techniques that will become available at Brookhaven's new light source, NSLS-II, now under construction.

Gang's collaborators on this work include Brookhaven colleagues Mudalige Kumara, Dmytro Nykypanchuk and William Sherman, as well as Mathew Maye, a former Brookhaven chemist now at Syracuse University. The research was funded by the DOE Office of Science, by a Laboratory Directed Research and Development grant, and by a Goldhaber Distinguished Fellowship. Brookhaven Science Associates, which manages Brookhaven Lab, has filed patent applications related to this work. For information about these patents and licensing opportunities, contact Kimberley Elcess, 631 344-4151.

Upon publication, the paper will be available at: dx.doi.org/10.1038/NNANO.2009.378.

Related Links

* DNA-Based Assembly Line for Precision Nano-Cluster Construction:

www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=921

* DNA Technique Yields 3-D Crystalline Organization of Nanoparticles:

www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=07-127

* New DNA-Based Technique For Assembly of Nano- and Micro-sized Particles:

www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=07-94

* Nanoparticle Assembly Enters the Fast Lane:

www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=06-112

####

About Brookhaven National Laboratory
One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry, and government researchers. Brookhaven is operated and managed for DOEs Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation of the State University of New York, for and on behalf of Stony Brook University, the largest academic user of Laboratory facilities; and Battelle Memorial Institute, a nonprofit, applied science and technology organization. Visit Brookhaven Lab's electronic newsroom for links, news archives, graphics, and more (www.bnl.gov/newsroom), or follow Brookhaven Lab on Twitter (twitter.com/BrookhavenLab).

About the Center for Functional Nanomaterials

The Center for Functional Nanomaterials at Brookhaven National Laboratory is one of the five DOE Nanoscale Science Research Centers (NSRCs), premier national user facilities for interdisciplinary research at the nanoscale. Together the NSRCs comprise a suite of complementary facilities that provide researchers with state-of-the-art capabilities to fabricate, process, characterize and model nanoscale materials, and constitute the largest infrastructure investment of the National Nanotechnology Initiative. The NSRCs are located at DOE's Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge and Sandia and Los Alamos national laboratories. For more information about the DOE NSRCs, please visit nano.energy.gov.


For more information, please click here

Contacts:
Karen McNulty Walsh

(631) 344-8350

Mona Rowe

(631) 344-5056

Copyright © Brookhaven National Laboratory

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Synthetic Biology

Democratizing synthetic biology: New method makes research cheaper, faster, and more accessible March 3rd, 2015

New tool could help reshape the limits of synthetic biology: The 'telomerator' reshapes synthetic yeast chromosome into more flexible, realistic form, redefining what geneticists can build November 3rd, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Smallest world record has 'endless possibilities' for bio-nanotechnology October 8th, 2014

Possible Futures

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotechnology Drug Delivery Market in the US 2012-2016 : Latest Report Available by Radiant Insights, Inc March 16th, 2015

Memory Technology

Nano piano's lullaby could mean storage breakthrough March 16th, 2015

Nanotechnology Helps Increasing Rate of Digital Data Processing, Storage March 9th, 2015

Iranian Scientists Apply Nanotechnology to Produce Electrical Insulator March 7th, 2015

Magnetic vortices in nanodisks reveal information: Researchers from Dresden and Jülich use microwaves to read out information from smallest storage devices March 4th, 2015

Self Assembly

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Four Scientists With Major Contributions to Research at Brookhaven Lab Named American Physical Society Fellows March 17th, 2015

Nanotubes self-organize and wiggle: Evolution of a nonequilibrium system demonstrates MEPP February 10th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Sensors

UW scientists build a nanolaser using a single atomic sheet March 24th, 2015

Iranian Researchers Present Model to Determine Dynamic Behavior of Nanostructures March 24th, 2015

Nanodevice Invented in Iran to Detect Hydrogen Sulfide in Oil, Gas Industry March 20th, 2015

LamdaGen Corporation Launches Taiwan Diagnostic Subsidiary March 19th, 2015

Announcements

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Energy

LAMDAMAP 2015 hosted by the University March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

Hong Kong Investors Bullish on Dais Analytic Invest $5.75M, Provide $60M Contract, and Create New Joint Venture Company March 26th, 2015

Industrial Nanotech, Inc. Announces Next Large Order from the Oil and Gas Industry March 26th, 2015

Nanobiotechnology

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

Solar/Photovoltaic

LAMDAMAP 2015 hosted by the University March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

New kind of 'tandem' solar cell developed: Researchers combine 2 types of photovoltaic material to make a cell that harnesses more sunlight March 24th, 2015

Caltech scientists develop cool process to make better graphene March 18th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE