Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New Technology Could Boost Disease Detection Tests’ Speed and Sensitivity

Ayse Rezzan Kose (above) and Hur Koser developed a new method for identifying and sorting diseased cells in blood samples using magnetic nanoparticles.
Ayse Rezzan Kose (above) and Hur Koser developed a new method for identifying and sorting diseased cells in blood samples using magnetic nanoparticles.

Abstract:
A team led by Yale University scientists has developed a way to rapidly manipulate and sort different cells in the blood using magnetizable liquids. The findings, which will be published the week of December 7 in the online edition of the Proceedings of the National Academy of Sciences, could dramatically improve the speed and sensitivity of tests used to detect cancer biomarkers, blood disorders, viruses and other diseases.

New Technology Could Boost Disease Detection Tests’ Speed and Sensitivity

New Haven, CT | Posted on December 14th, 2009

Ferrofluids are comprised of magnetic nanoparticles suspended throughout a liquid carrier. They have been used in industrial applications for years, including in hard disk drives and loudspeakers. Now a team led by Hur Koser, associate professor at the Yale School of Engineering & Applied Science, has developed a biocompatible ferrofluid—one with the right pH level and salinity so that human cells can survive in it for several hours—and has created a device with integrated electrodes that generate a magnetic field pattern, allowing them to manipulate and separate red blood cells, sickle cells and bacteria contained in this unique solution.

The magnetic field attracts the nanoparticles in the ferrofluid, effectively pushing and shuffling the much larger, nonmagnetic cells along specific channels. Depending on the frequency of the magnetic field they apply, the researchers are also able to manipulate and sort different types of cells depending on their size, elasticity and shape.

"It's like the cells are surfing on magnetic forces," Koser said. "When we turn on the magnetic field, the nonmagnetic cells are pushed immediately up to the top of the channel." There, they roll along the surface and can be quickly directed toward a sensor.

While other cell manipulation techniques exist, this new method is unique in that it doesn't require attaching biomarkers, or labels, to the cells and there is no need for labor-intensive preparation or post-processing.

Being able to effectively sort and move cells with this technique could allow for much greater efficiency in disease detection by directing diseased cells toward sensors. Many of today's tests require hours or even days to complete, because the concentration of diseased cells in a blood sample may be so low that it takes a long time for them to randomly bump into the sensors. In early-stage cancer, for instance, there could be one tumor cell for every billion healthy cells, making them extremely difficult to detect.

"Effective and efficient separation is very important when you're looking for a needle in a haystack," said Ayse Rezzan Kose, a graduate student in the Koser Lab and the lead author of the study. "We're hoping we can achieve an increase of several orders of magnitude in the sensitivity of existing detection technologies. If so, a blood sample analysis could be completed in minutes, not hours or days."

Koser hopes that one day the new technique will lead to portable sensors that doctors can carry into the field and which could be used to test for a range of disorders, such as cancer and HIV. "Anything you can put into the ferrofluid solution is potentially detectable in this manner."

Authors of the paper include Ayse Rezzan Kose and Hur Koser (Yale University), Birgit Fischer (Deutsches Elektronen-Synchrotron) and Leidong Mao (University of Georgia).

This research was funded by the National Science Foundation, the National Institutes of Health and the Yale Institute for Nanoscience and Quantum Engineering.

Citation: 10.1073/pnas.0912138106

####

About Yale University
Yale University comprises three major academic components: Yale College (the undergraduate program), the Graduate School of Arts and Sciences, and the professional schools. In addition, Yale encompasses a wide array of centers and programs, libraries, museums, and administrative support offices. Approximately 11,250 students attend Yale

For more information, please click here

Contacts:
Press Contact
Suzanne Taylor Muzzin
203-432-8555

Copyright © Yale University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Possible Futures

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Academic/Education

Graphene: Progress, not quantum leaps May 23rd, 2016

Smithsonian Science Education Center and National Space Society Team Up for Next-Generation Space Education Program "Enterprise In Space" May 11th, 2016

The University of Colorado Boulder, USA, combines Raman spectroscopy and nanoindentation for improved materials characterisation May 9th, 2016

Albertan Science Lab Opens in India May 7th, 2016

Nanomedicine

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Sensors

The next generation of carbon monoxide nanosensors May 26th, 2016

Dartmouth team creates new method to control quantum systems May 24th, 2016

Electronic device detects molecules linked to cancer, Alzheimer's and Parkinson's: An inexpensive portable biosensor has been developed by researchers at Brazil's National Nanotechnology Laboratory with FAPESP's support May 20th, 2016

Making organs transparent to improve nanomedicine (video) May 13th, 2016

Announcements

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanobiotechnology

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic