Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New Technology Could Boost Disease Detection Tests’ Speed and Sensitivity

Ayse Rezzan Kose (above) and Hur Koser developed a new method for identifying and sorting diseased cells in blood samples using magnetic nanoparticles.
Ayse Rezzan Kose (above) and Hur Koser developed a new method for identifying and sorting diseased cells in blood samples using magnetic nanoparticles.

Abstract:
A team led by Yale University scientists has developed a way to rapidly manipulate and sort different cells in the blood using magnetizable liquids. The findings, which will be published the week of December 7 in the online edition of the Proceedings of the National Academy of Sciences, could dramatically improve the speed and sensitivity of tests used to detect cancer biomarkers, blood disorders, viruses and other diseases.

New Technology Could Boost Disease Detection Tests’ Speed and Sensitivity

New Haven, CT | Posted on December 14th, 2009

Ferrofluids are comprised of magnetic nanoparticles suspended throughout a liquid carrier. They have been used in industrial applications for years, including in hard disk drives and loudspeakers. Now a team led by Hur Koser, associate professor at the Yale School of Engineering & Applied Science, has developed a biocompatible ferrofluid—one with the right pH level and salinity so that human cells can survive in it for several hours—and has created a device with integrated electrodes that generate a magnetic field pattern, allowing them to manipulate and separate red blood cells, sickle cells and bacteria contained in this unique solution.

The magnetic field attracts the nanoparticles in the ferrofluid, effectively pushing and shuffling the much larger, nonmagnetic cells along specific channels. Depending on the frequency of the magnetic field they apply, the researchers are also able to manipulate and sort different types of cells depending on their size, elasticity and shape.

"It's like the cells are surfing on magnetic forces," Koser said. "When we turn on the magnetic field, the nonmagnetic cells are pushed immediately up to the top of the channel." There, they roll along the surface and can be quickly directed toward a sensor.

While other cell manipulation techniques exist, this new method is unique in that it doesn't require attaching biomarkers, or labels, to the cells and there is no need for labor-intensive preparation or post-processing.

Being able to effectively sort and move cells with this technique could allow for much greater efficiency in disease detection by directing diseased cells toward sensors. Many of today's tests require hours or even days to complete, because the concentration of diseased cells in a blood sample may be so low that it takes a long time for them to randomly bump into the sensors. In early-stage cancer, for instance, there could be one tumor cell for every billion healthy cells, making them extremely difficult to detect.

"Effective and efficient separation is very important when you're looking for a needle in a haystack," said Ayse Rezzan Kose, a graduate student in the Koser Lab and the lead author of the study. "We're hoping we can achieve an increase of several orders of magnitude in the sensitivity of existing detection technologies. If so, a blood sample analysis could be completed in minutes, not hours or days."

Koser hopes that one day the new technique will lead to portable sensors that doctors can carry into the field and which could be used to test for a range of disorders, such as cancer and HIV. "Anything you can put into the ferrofluid solution is potentially detectable in this manner."

Authors of the paper include Ayse Rezzan Kose and Hur Koser (Yale University), Birgit Fischer (Deutsches Elektronen-Synchrotron) and Leidong Mao (University of Georgia).

This research was funded by the National Science Foundation, the National Institutes of Health and the Yale Institute for Nanoscience and Quantum Engineering.

Citation: 10.1073/pnas.0912138106

####

About Yale University
Yale University comprises three major academic components: Yale College (the undergraduate program), the Graduate School of Arts and Sciences, and the professional schools. In addition, Yale encompasses a wide array of centers and programs, libraries, museums, and administrative support offices. Approximately 11,250 students attend Yale

For more information, please click here

Contacts:
Press Contact
Suzanne Taylor Muzzin
203-432-8555

Copyright © Yale University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Ultrathin device harvests electricity from human motion July 23rd, 2017

The July 23 close fly-by of asteroid 2017 BS5 is explored in a Q&A with Dr. John S. Lewis, chief scientist at Deep Space Industries July 23rd, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

Possible Futures

Ultrathin device harvests electricity from human motion July 23rd, 2017

The July 23 close fly-by of asteroid 2017 BS5 is explored in a Q&A with Dr. John S. Lewis, chief scientist at Deep Space Industries July 23rd, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

Academic/Education

The Physics Department of Imperial College, London, uses the Quorum Q150T to deposit metals and ITO to make plasmonic sensors and electric contact pads July 13th, 2017

Oxford Instruments congratulates Lancaster University for inaugurating the IsoLab, built for studying quantum systems June 20th, 2017

The 2017 Winners for Generation Nano June 8th, 2017

MIT Energy Initiative awards 10 seed fund grants for early-stage energy research May 4th, 2017

Nanomedicine

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

'Upconverted' light has a bright future: Rice University professor developing plasmon-powered devices for medicine, security, solar cells July 17th, 2017

Sensors

Giant enhancement of electromagnetic waves revealed within small dielectric particles: Scientists have done for the first time direct measurements of giant electromagnetic fields July 8th, 2017

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Leti’s Autonomous-Vehicle System Embedded in Infineon’s AURIX Platform: Leti’s Low-Power, Multi-Sensor System that Transforms Distance Data into Clear Information About the Driving Environment Will Be Demonstrated at ITS Meeting in Strasbourg, June 19-22 June 20th, 2017

New diode features optically controlled capacitance: Israeli researchers have developed a new optically tunable capacitor with embedded metal nanoparticles, creating a metal-insulator-semiconductor diode that is tunable by illumination. June 8th, 2017

Announcements

Ultrathin device harvests electricity from human motion July 23rd, 2017

The July 23 close fly-by of asteroid 2017 BS5 is explored in a Q&A with Dr. John S. Lewis, chief scientist at Deep Space Industries July 23rd, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

Nanobiotechnology

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

Nanomedicine opens door to precision medicine for brain tumors July 12th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project