Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanomedicine: ending 'hit and miss' design

Jennifer West, Isabel C. Cameron Professor of Bioengineering
Jennifer West, Isabel C. Cameron Professor of Bioengineering

Abstract:
Rice, TMC team wins stimulus funds for nanoparticle standardization.

Nanomedicine: ending 'hit and miss' design

Houston, TX | Posted on December 9th, 2009

One of the promises of nanomedicine is the design of tiny particles that can home in on diseased cells and get inside them. Nanoparticles can carry drugs into cells and tag cells for MRI and other diagnostic tests; and they may eventually even enter a cell's nucleus to repair damaged genes. Unfortunately, designing them involves as much luck as engineering.

"Everything in nanomedicine right now is hit-and-miss as far as the biological fate of nanoparticles," said Rice University bioengineering researcher Jennifer West. "There's no systematic understanding of how to design a particle to accomplish a certain goal in terms of where it goes in a cell or if it even goes into a cell."

West's lab and 11 others in the Texas Medical Center -- including three at Rice's BioScience Research Collaborative -- are hoping to change that, thanks to a $3 million Grand Opportunity (GO) grant from the National Institutes of Health. NIH established the GO grant program with funding from the American Recovery and Reinvestment Act (ARRA).

One problem facing scientists today is that nanoparticles come in many shapes and sizes and can be made of very different materials. Some nanoparticles are spherical. Others are long and thin. Some are made of biodegradable plastic and others of gold, carbon or semiconducting metals. And sometimes size -- rather than shape or material -- is all-important.

West demonstrates this using a video on her computer that was created by Rice GO grant investigator Junghae Suh. The movie was created by snapping an image with a microscope every few seconds. In the video, dozens of particles move about inside a cell. Half of the particles are tagged with a red fluorescent dye and move very slowly. The rest are green and zip from place to place.

"These are made of the same material and have the same chemistry," said West, Rice's Isabel C. Cameron Professor and department chair of Bioengineering. "They are just different sizes. Yet you can see the profound differences in how they are moving in the cell. As we start to explore out further in the range of sizes and in altering the chemistry of the particles, we think we're likely to see even bigger impacts on where things go inside the cell."

The job of determining whether that's the case falls to Suh, assistant professor in bioengineering at Rice. Unlike other studies in the field, which rely on snapshots of dead cells, Suh's method lets researchers track single particles in living cells. Her lab will use the method in side-by-side comparisons of particles provided by the other 11 laboratories in the study.

In all, eight classes of nanoparticles will be studied. These include long, thin tubes of pure carbon called fullerenes, tiny specks of semiconductors called quantum dots, pure gold rods and spheres, as well as nanoshells -- nanoparticles invented at Rice that consist of a glass core covered by a thin gold shell. In addition, Suh's lab will examine organic particles made of polyethylene glycol and of chitosan.

"We will use a method called single-particle tracking to capture the dynamics of nanoparticle movement in live cells," Suh said. "Using confocal microscopy, we first create movies of the particles as they transit the cells. Then, we use image-processing software to extract information about how fast they move, what regions they're attracted to, etc. By comparing the movement and fate of the various nanoparticles designed by the multiple research laboratories, we hope to identify correlations between a nanoparticle's physicochemical properties and their intracellular behavior."

At the end of the two-year study, the team hopes to have a database that charts the expected response of particles of a given size, type and chemistry. Ultimately, the hope is to provide researchers with a tool that will help predict how a particular particle is likely to behave. That, in turn, could help researchers speed the development of new treatments for disease.

"We want to understand where the particles go inside the cell, what organelles they associate with, whether or not they associate with any of the cytoskeletal structures and how they move inside the cell," Suh said. "For different applications, you're going to want your particles going to different places. We need to know where they go and how they behave so we can design the right particle for a particular job."

"We are thrilled to get the opportunity to really join forces to study this," Suh said. "It's just the sort of problem that requires the kind of support NIH is providing with ARRA funding. It's a problem that really requires a multidisciplinary, interinstitutional approach."

The project's other principal investigators include Rebekah Drezek and Lon Wilson, both of Rice; Mauro Ferrari, Paolo Decuzzi, David Gorenstein, Jim Klostergaard, Chun Li, Gabriel Lopez-Berestein and Anil Sood, all of the University of Texas Health Science Center at Houston; and Wah Chiu of Baylor College of Medicine.

GO grant funding is provided by the NIH's National Institute of General Medical Sciences. NIH established the GO grant program to support projects that address large, specific research endeavors that are likely to deliver near-term growth and investment in biomedical research and development, public health and health care delivery.

####

Contacts:
Jade Boyd
PHONE: 713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

QD Vision Expands Product Line with Two-Millimeter Color LCD Display Optic: Color IQ™ Optic Enables Full-Color Gamut for Ultra-Thin Displays and All-in-One Computers April 16th, 2015

The National Science Foundation names engineering researcher Andrea Alú its Alan T. Waterman awardee for 2015: Alú is a pioneer in the field of metamaterials who has developed "cloaking" technology to make objects invisible to sensors April 16th, 2015

Chemistry

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

The National Science Foundation names engineering researcher Andrea Alú its Alan T. Waterman awardee for 2015: Alú is a pioneer in the field of metamaterials who has developed "cloaking" technology to make objects invisible to sensors April 16th, 2015

Long Island Capital Alliance Announces Participants for Brookhaven National Laboratory Technology Transfer Capital Forum on May 8: Keynote Speaker Dr. Doon Gibbs, Director of Brookhaven National Laboratory April 16th, 2015

Major advance in artificial photosynthesis poses win/win for the environment: Berkeley Lab researchers perform solar-powered green chemistry with captured CO2 April 16th, 2015

Possible Futures

A glass fiber that brings light to a standstill: By coupling photons to atoms, light in a glass fiber can be slowed down to the speed of an express train; for a short while it can even be brought to a complete stop April 9th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotubes/Buckyballs

Nanotubes with two walls have singular qualities: Rice University lab calculates unique electronic qualities of double-walled carbon nanotubes April 16th, 2015

MIT sensor detects spoiled meat: Tiny device could be incorporated into 'smart packaging' to improve food safety April 15th, 2015

Taking aircraft manufacturing out of the oven: New technique uses carbon nanotube film to directly heat and cure composite materials April 14th, 2015

Iranian Scientists Evaluate Dynamic Interaction between 2 Carbon Nanotubes April 14th, 2015

Nanomedicine

Novel nanoparticles could save soldiers' lives after explosions April 15th, 2015

Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors April 14th, 2015

Iranian Scientists Evaluate Dynamic Interaction between 2 Carbon Nanotubes April 14th, 2015

Gold by special delivery intensifies cancer-killing radiation April 13th, 2015

Announcements

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

Newly-Developed Nanocatalysts Increase Performance of Fuel Cells April 16th, 2015

Lanthanide-Organic Framework Nanothermometers Prepared by Spray-Drying April 16th, 2015

Quantum Dots/Rods

QD Vision Expands Product Line with Two-Millimeter Color LCD Display Optic: Color IQ™ Optic Enables Full-Color Gamut for Ultra-Thin Displays and All-in-One Computers April 16th, 2015

Promising future of quantum dots explored in conference: ‘20 Years of Quantum Dots at Los Alamos’ runs April 12-16 April 13th, 2015

Next important step toward quantum computer: Scientists at the University of Bonn have succeeded in linking 2 different quantum systems March 30th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

Nanobiotechnology

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Study shows novel pattern of electrical charge movement through DNA April 14th, 2015

UAB researchers develop a harmless artificial virus for gene therapy April 8th, 2015

Pavel Levkin Is Granted Heinz Maier-Leibnitz Prize April 8th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE