Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanomedicine: ending 'hit and miss' design

Jennifer West, Isabel C. Cameron Professor of Bioengineering
Jennifer West, Isabel C. Cameron Professor of Bioengineering

Abstract:
Rice, TMC team wins stimulus funds for nanoparticle standardization.

Nanomedicine: ending 'hit and miss' design

Houston, TX | Posted on December 9th, 2009

One of the promises of nanomedicine is the design of tiny particles that can home in on diseased cells and get inside them. Nanoparticles can carry drugs into cells and tag cells for MRI and other diagnostic tests; and they may eventually even enter a cell's nucleus to repair damaged genes. Unfortunately, designing them involves as much luck as engineering.

"Everything in nanomedicine right now is hit-and-miss as far as the biological fate of nanoparticles," said Rice University bioengineering researcher Jennifer West. "There's no systematic understanding of how to design a particle to accomplish a certain goal in terms of where it goes in a cell or if it even goes into a cell."

West's lab and 11 others in the Texas Medical Center -- including three at Rice's BioScience Research Collaborative -- are hoping to change that, thanks to a $3 million Grand Opportunity (GO) grant from the National Institutes of Health. NIH established the GO grant program with funding from the American Recovery and Reinvestment Act (ARRA).

One problem facing scientists today is that nanoparticles come in many shapes and sizes and can be made of very different materials. Some nanoparticles are spherical. Others are long and thin. Some are made of biodegradable plastic and others of gold, carbon or semiconducting metals. And sometimes size -- rather than shape or material -- is all-important.

West demonstrates this using a video on her computer that was created by Rice GO grant investigator Junghae Suh. The movie was created by snapping an image with a microscope every few seconds. In the video, dozens of particles move about inside a cell. Half of the particles are tagged with a red fluorescent dye and move very slowly. The rest are green and zip from place to place.

"These are made of the same material and have the same chemistry," said West, Rice's Isabel C. Cameron Professor and department chair of Bioengineering. "They are just different sizes. Yet you can see the profound differences in how they are moving in the cell. As we start to explore out further in the range of sizes and in altering the chemistry of the particles, we think we're likely to see even bigger impacts on where things go inside the cell."

The job of determining whether that's the case falls to Suh, assistant professor in bioengineering at Rice. Unlike other studies in the field, which rely on snapshots of dead cells, Suh's method lets researchers track single particles in living cells. Her lab will use the method in side-by-side comparisons of particles provided by the other 11 laboratories in the study.

In all, eight classes of nanoparticles will be studied. These include long, thin tubes of pure carbon called fullerenes, tiny specks of semiconductors called quantum dots, pure gold rods and spheres, as well as nanoshells -- nanoparticles invented at Rice that consist of a glass core covered by a thin gold shell. In addition, Suh's lab will examine organic particles made of polyethylene glycol and of chitosan.

"We will use a method called single-particle tracking to capture the dynamics of nanoparticle movement in live cells," Suh said. "Using confocal microscopy, we first create movies of the particles as they transit the cells. Then, we use image-processing software to extract information about how fast they move, what regions they're attracted to, etc. By comparing the movement and fate of the various nanoparticles designed by the multiple research laboratories, we hope to identify correlations between a nanoparticle's physicochemical properties and their intracellular behavior."

At the end of the two-year study, the team hopes to have a database that charts the expected response of particles of a given size, type and chemistry. Ultimately, the hope is to provide researchers with a tool that will help predict how a particular particle is likely to behave. That, in turn, could help researchers speed the development of new treatments for disease.

"We want to understand where the particles go inside the cell, what organelles they associate with, whether or not they associate with any of the cytoskeletal structures and how they move inside the cell," Suh said. "For different applications, you're going to want your particles going to different places. We need to know where they go and how they behave so we can design the right particle for a particular job."

"We are thrilled to get the opportunity to really join forces to study this," Suh said. "It's just the sort of problem that requires the kind of support NIH is providing with ARRA funding. It's a problem that really requires a multidisciplinary, interinstitutional approach."

The project's other principal investigators include Rebekah Drezek and Lon Wilson, both of Rice; Mauro Ferrari, Paolo Decuzzi, David Gorenstein, Jim Klostergaard, Chun Li, Gabriel Lopez-Berestein and Anil Sood, all of the University of Texas Health Science Center at Houston; and Wah Chiu of Baylor College of Medicine.

GO grant funding is provided by the NIH's National Institute of General Medical Sciences. NIH established the GO grant program to support projects that address large, specific research endeavors that are likely to deliver near-term growth and investment in biomedical research and development, public health and health care delivery.

####

Contacts:
Jade Boyd
PHONE: 713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Multi-million pound project to use nanotechnology to improve safety September 4th, 2015

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Tongfang Global and QD Vision Partner to Bring Wide Color Gamut to Global Television Lines: Color IQTM quantum dots help boost company’s focus on superior color reproduction September 3rd, 2015

QEOS and GLOBALFOUNDRIES to Offer Industry’s First CMOS Platform for MillimeterWave Markets: GLOBALSOLUTIONSSM Partnership will enable next-generation wireless technologies for applications in IoT, 5G and automotive September 3rd, 2015

Chemistry

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Laser-burned graphene gains metallic powers: Rice University scientists find possible replacement for platinum as catalyst August 20th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Making nanowires from protein and DNA September 3rd, 2015

Making fuel from light: Argonne research sheds light on photosynthesis and creation of solar fuel September 3rd, 2015

Reversible Writing with Light: Self-assembling nanoparticles take their cues from their surroundings September 3rd, 2015

Possible Futures

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Harris & Harris Group Reports Financial Statements as of June 30, 2015, and Announces a Stock Repurchase Program August 10th, 2015

Nanotubes/Buckyballs/Fullerenes

For 2-D boron, it's all about that base: Rice University theorists show flat boron form would depend on metal substrates September 2nd, 2015

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Developing Component Scale Composites Using Nanocarbons August 26th, 2015

Southampton scientists find new way to detect ortho-para conversion in water August 25th, 2015

Nanomedicine

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Making nanowires from protein and DNA September 3rd, 2015

Reversible Writing with Light: Self-assembling nanoparticles take their cues from their surroundings September 3rd, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Announcements

Multi-million pound project to use nanotechnology to improve safety September 4th, 2015

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Making nanowires from protein and DNA September 3rd, 2015

Making fuel from light: Argonne research sheds light on photosynthesis and creation of solar fuel September 3rd, 2015

Quantum Dots/Rods

Tongfang Global and QD Vision Partner to Bring Wide Color Gamut to Global Television Lines: Color IQTM quantum dots help boost company’s focus on superior color reproduction September 3rd, 2015

'Quantum dot' technology may help light the future August 19th, 2015

New research may enhance display & LED lighting technology: Large-area integration of quantum dots and photonic crystals produce brighter and more efficient light August 9th, 2015

Quantum networks: Back and forth are not equal distances! July 28th, 2015

Nanobiotechnology

Making nanowires from protein and DNA September 3rd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells August 30th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic