Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > A Nanoscale Development With Macro Potential

Assistant professor Andrew MacKay.  
Photo/Kukla Vera
Assistant professor Andrew MacKay. Photo/Kukla Vera

Abstract:
The future of cancer treatment might be microscopic in size, at least according to USC School of Pharmacy assistant professor Andrew MacKay's groundbreaking research.

A Nanoscale Development With Macro Potential

Los Angeles, CA | Posted on December 9th, 2009

MacKay developed new strategies that, when executed on a nanoscale, have successfully led to tumor regression. The strategies involve the self-assembly of genetically engineered materials into nanoscale, drug-loaded packages.

MacKay and his team developed an artificial recombinant, chimeric polypeptide (CP) that spontaneously self-assembles into near-monodisperse, 40-nm-sized nanoparticles. His group demonstrated that this approach is a general and simple strategy to form drug-loaded nanomedicines from safe, biodegradable polypeptides.

These nanomedicines were used to deliver chemotherapeutics to mouse tumors and proved to be more effective than free drugs (an active drug that is not bound to a carrier protein). Not only did drug tolerance increase fourfold, but the use of these innovative chemotherapeutics led to nearly complete tumor regression after only a single dose. While the tumor used in the laboratory was associated with colon cancer in mice, this approach also could be used to treat a variety of cancers.

MacKay believes that packaging drugs into nanoscale delivery vehicles could be particularly useful for cancer therapy. Until now, mechanisms to assemble nanomedicines have relied on complex strategies using non-biocompatible materials.

To overcome this deficiency, MacKay and co-workers designed their drug carriers from a polypeptide sequence found in an elastic protein in human tissues. MacKay identified this approach as one of the necessary criteria to develop effective cancer drug treatments. The genetically engineered chimeric polypeptide molecules allow for this assembly and are novel for their generality, simplicity and biodegradability.

Although MacKay's developments are on a small scale, their impact has huge potential. His work with chimeric polypeptide and nanomedicines was featured in Nature Materials in November.

####

About University of Southern California
Located in Los Angeles, a global center for arts, technology and international trade, the University of Southern California is one of the world’s leading private research universities. USC enrolls more international students than any other U.S. university and offers extensive opportunities for internships and study abroad. With a strong tradition of integrating liberal and professional education, USC fosters a vibrant culture of public service and encourages students to cross academic as well as geographic boundaries in their pursuit of knowledge.

For more information, please click here

Contacts:

Copyright © University of Southern California

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Possible Futures

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Self Assembly

Tiny nanomachine successfully completes test drive: Researchers at the University of Bonn and the research institute Caesar build a one-wheeled vehicle out of DNA rings April 11th, 2018

Liquid crystal molecules form nano rings: Quantized self-assembly enables design of materials with novel properties February 7th, 2018

Particle size matters for porous building blocks: Rice University scientists find porous nanoparticles get tougher under pressure, but not when assembled December 19th, 2017

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Nanomedicine

Getting a better look at living cells April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizard® AFM to help in the characterization of cardiomyopathies April 24th, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Announcements

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Nanobiotechnology

Getting a better look at living cells April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizard® AFM to help in the characterization of cardiomyopathies April 24th, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project