Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > A little magic provides an atomic-level look at bone

Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy

Abstract:
A new study using solid-state NMR spectroscopy to analyze intact bone paves the way for atomic-level explorations of how disease and aging affect bone.

A little magic provides an atomic-level look at bone

Ann Arbor, MI | Posted on December 4th, 2009

The research by scientists at the University of Michigan is reported in the Dec. 2 issue of the Journal of the American Chemical Society.

"If people think of bone at all—and they usually don't, until they have a fracture—they think of it as an inert material," said Ayyalusamy Ramamoorthy, professor of chemistry and of biophysics. "But like everything else, bone is also made up of molecules whose behavior is reflected in its structure, toughness and mechanical strength, making bone really exciting in terms of its chemistry and its contribution to health and well-being,"

As scientists strive to understand the human body and its diseases in terms of molecular behavior, bone presents a challenge to most analytical techniques. "However, solid-state NMR spectroscopy is an ideal tool for exploring what goes on inside bone at nanoscopic resolution," Ramamoorthy said. "It is possible to probe the structure and dynamics of individual molecules that constitute bone without any physical damage or chemical modification."

But while solid-state NMR spectroscopy is capable of revealing complete nanoscopic details of molecular events from most samples, it often provides so many details that they're difficult to tease apart and analyze. Ramamoorthy, whose children are fans of the Magic School Bus science series, challenged his lab group to find ways of "driving around" to explore the interior of bone, just as characters on the series might in their imaginary world. The researchers' real-world approach involved a different kind of magic.

Ramamoorthy and colleagues used a variation of solid-state NMR (nuclear magnetic resonance) spectroscopy called magic-angle spinning, a non-invasive technique that makes solid material as amenable to analysis as solutions are. Previous NMR studies have used pulverized bone, but the U-M group's instruments and methods made it possible to analyze a sample of intact cow bone. The bone sample was shaped to just fit the rotor that is spun at the so-called magic angle inside the probe of a solid-state NMR spectrometer.

With this technique, the researchers examined changes that occur in bone with water loss. The water content of bone tissue decreases with age, which—by affecting both collagen and minerals—reduces bone's strength and toughness.

"We were able to see dynamical structural changes with the main protein, collagen," Ramamoorthy said. "Its characteristic triple helix structure was not completely damaged, but its mobility was altered, in addition to a disorder in the structure."

The success of the study makes possible future research into how bone's constituents behave under different conditions.

"We'd like to look at how bone changes at the atomic level, as a function of aging," Ramamoorthy said, "and to make comparisons between diseased and healthy bone." Such studies may provide insights into the susceptibility of bone to fracture, especially in the osteoporotic tissues of many elderly people.

Ramamoorthy's coauthors on the paper are postdoctoral fellows Peizhi Zhu and Jiadi Xu, graduate student Nadder Sahar, chemistry professor Michael Morris and David Kohn, professor of biomedical engineering and of dentistry.

Funding was provided by the National Institutes of Health, the National Science Foundation and the Department of Defense.

####

About University of Michigan
The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future.

For more information, please click here

Contacts:
Nancy Ross-Flanigan
(734) 647-1853

Copyright © University of Michigan

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Govt.-Legislation/Regulation/Funding/Policy

SEFCU, SUNY Poly CNSE Announce Winning Student-Led Teams in the 6th Annual $500,000 New York Business Plan Competition April 25th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Electron spin brings order to high entropy alloys April 23rd, 2015

Possible Futures

Printing Silicon on Paper, with Lasers April 21st, 2015

A glass fiber that brings light to a standstill: By coupling photons to atoms, light in a glass fiber can be slowed down to the speed of an express train; for a short while it can even be brought to a complete stop April 9th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanomedicine

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Announcements

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Tools

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Quantum 'paparazzi' film photons in the act of pairing up April 22nd, 2015

Richards-Kortum elected to American Academy of Arts and Sciences: April 22nd, 2015

Nanobiotechnology

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Scientists Use Nanoscale Building Blocks and DNA 'Glue' to Shape 3D Superlattices: New approach to designing ordered composite materials for possible energy applications April 23rd, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Rafts on the cell membrane: Researchers from TU Wien (Vienna) shed light on a big secret of cell membranes: The 'lipid rafts', which have been believed to move within the cell membrane, do not really exist April 21st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project