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Abstract:
Our pure silicon nanoporous UltraSMŽ membranes are not only useful for electron microscopy, but also cell biology. In many studies of cell biology, one is interested in understanding how two cell populations interact or affect one another.
Cell biology on nanoporous UltraSMŽ membranes
Rochester, NY | Posted on November 21st, 2009This is important in studies of developmental biology, stem cell research as well as tissue and artifical organ engineering. Conventional materials used for co-culture studies consist of thick polymeric membranes that can trap low abundance short-distance signaling molecules that cells use to communicate. SiMPore's nanoporous nanometer-thick membrane is ideal for studying two cell populations that are physically separated, but closely enough to easily communicate. Physical separation is important in many cellular studies where one cell type is harvested and isolated after co-culture. The figure above shows this ideal co-culture environment.
To demonstrate the thinness and transparency of our UltraSMŽ membranes, we plated human white blood cells on the top and bottom surface of the membrane. In imaging the cells, we focused from beneath the membrane, to membrane height and then above the membrane. Unlike traditional co-culture membranes, the 15 nm thick UltraSMŽ membrane is invisible and does not degrade the image quality of the cells on the top.
SiMPore and our academic partners are currently using UltraSMŽ membranes in additional formats to study everything from cell-cell communication to investigating improved drug permeability assays and even developing tissue engineering platforms. If you would like to learn more or work with us towards developing a better co-culture platform, feel free to contact me:
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About SiMPore
SiMPore is a nanotechnology materials company based in Rochester, NY developing and commercializing products for materials and life sciences communities.
For more information, please click here
Contacts:
SiMPore Inc.
150 Lucius Gordon Dr.
Suite 100
West Henrietta, NY 14586
888-249-2935
Copyright © SiMPore
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