Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > When It Comes to Drug Delivery, Size Matters

Abstract:
One of the great promises of nanotechnologies lies in its ability to create drug-containing nanoparticles decorated with targeting molecules that recognize and bind to cancer cells, providing drug delivery only at the site of the targeted cells. Such site-specific drug delivery would not only boost the cancer-killing activity of a drug payload but also reduce potential side effects by greatly restricting or even eliminating the amount of drug reaching healthy tissue.

When It Comes to Drug Delivery, Size Matters

Bethesda, MD | Posted on November 18th, 2009

It turns out, though, that not all targeting agent-nanoparticle combinations are able to reach and enter their targets with equal effectiveness. To help bring some rationality to the process of designing targeted drug delivery agents, K. Dane Wittrup, Ph.D., and graduate student Micheal Schmidt of the Massachusetts Institute of Technology have developed a mathematical model that predicts the magnitude and specificity of tumor uptake of drug delivery vehicles ranging in size from small peptides to large liposomes. This work was published in the journal Molecular Cancer Therapeutics.

The model developed by the Schmidt and Wittrup, who is a member of the MIT-Harvard Center of Cancer Nanotechnology Excellence, accounts for the size of a particular drug delivery agent and a variety of easily measured properties, including how readily it crosses biological barriers and how tightly it binds to a target in test tube experiments. The researchers note that despite the simplicity of their model, it accurately predicts the behavior of HER2-targeted constructs in a mouse model of cancer and of CEA-targeted constructs in humans. In fact, it appears that size and target affinity account for most of the variability in tumor uptake.

One interesting prediction that the model makes is that large constructs, such as nanoparticles, and small ones, including targeting peptides, will deliver more drug into a tumor than will medium constructs, such as engineered antibody fragments. However, the model also predicts that delivery to tumors by nanoparticles over 50 nanometers in diameter will not improve much when targeting agents are aded to the nanoparticles.

This work, which is detailed in a paper titled, "A modeling analysis of the effects of molecular size and binding affinity on tumor targeting," was supported by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Possible Futures

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Nanomedicine

Getting a better look at living cells April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizard® AFM to help in the characterization of cardiomyopathies April 24th, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Announcements

Getting a better look at living cells April 25th, 2018

Graphene origami as a mechanically tunable plasmonic structure for infrared detection April 25th, 2018

Nuclear radiation detecting device could lead to new homeland security tool: New device can detect gamma rays and identify radioactive isotopes April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

Nanobiotechnology

Getting a better look at living cells April 25th, 2018

Biophysics -- lighting up DNA-based nanostructures April 25th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizard® AFM to help in the characterization of cardiomyopathies April 24th, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project