Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticles Detect and Purge Metastases in Lymph Nodes

Abstract:
Colonoscopy represents one of the great weapons against cancer. In one step, a physician can find precancerous lesions in the colon and then cut them out, an on-the-spot intervention that prevents cancer from developing. Now, researchers at the Winthrop Rockefeller Cancer Institute and the University of Arkansas for Medical Sciences have developed another fiber optic technique that can detect lymph node metastases and destroy them on the spot, an action that could prevent the further spread of breast cancer, melanoma, or gastrointestinal cancer, all of which spread through the lymphatic system.

Nanoparticles Detect and Purge Metastases in Lymph Nodes

Bethesda, MD | Posted on October 29th, 2009

As they report in the Journal of Biophotonics, Vladimir Zharov and his colleagues used polymer-coated iron oxide nanoparticles and gold-coated carbon nanotubes as the heart of an integrated system of several different analytical techniques and light-activated thermal therapy to detect and purge metastatic cells that invade sentinel lymph nodes. Both types of nanoparticles make excellent photoacoustic contrast enhancement agents, with each having its own characteristic interaction with pulses of laser light. When injected into mice, the investigators were able to quantify both types of nanoparticles as they accumulated in sentinel lymph nodes.

Dr. Zharov and his colleagues next showed that they could use photoacoustic techniques to detect both melanoma and breast cancer metastases in sentinel lymph nodes in mice. In fact, the investigators were able to map in real time the distribution of metastatic cells in the lymphatic system and count individual tumor cells in the sentinel lymph nodes. The researchers then showed that they could use a fiber optic laser probe to irradiate nanoparticles that accumulated in the lymph nodes. This irradiation rapidly heats the nanoparticles, generating microbubbles in the surrounding media. The eventual microbubble collapse releases energy that kills the metastatic cells. The entire procedure, including detection and destruction of metastatic cells, took less than 30 seconds.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "In vivo fiber-based multicolor photoacoustic detection and photothermal purging of metastasis in sentinel lymph nodes targeted by nanoparticles." Investigators from the Saratov State University and the Prokhorov General Physics Institute, both in Russia, the Indiana School of Medicine, and the University of Arkansas also participated in this study. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.
As part of the Center for Strategic Scientific Initiatives which is led by NCI Deputy Director Dr. Anna Barker, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
(301) 496-1550

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Possible Futures

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Nanomedicine

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Announcements

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanobiotechnology

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic