Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Gold Nanoparticles Delivery Platinum Warheads to Tumors

Abstract:
Cisplatin is one of the most powerful and effective drugs for treating a wide variety of cancers, but serious side effects ultimately limit the drug's use and effectiveness. Now, however, researchers have developed a nanoparticulate formulation of cisplatin that may be able to eliminate or reduce platinum-associated toxicity while boosting cisplatin's tumor-killing activity.

Gold Nanoparticles Delivery Platinum Warheads to Tumors

Bethesda, MD | Posted on October 29th, 2009

Reporting its work in the Journal of the American Chemical Society, a team of investigators led by Stephen Lippard, of the Massachusetts Institute of Technology, and Chad Mirkin, of Northwestern University and principal investigator of the Northwestern Center for Cancer Nanotechnology Excellence, describes its development and characterization of gold nanoparticles as a delivery vehicle for a non-toxic form of platinum known as platinum(IV). The gold nanoparticles are coated with short pieces of nucleic acid to which the investigators chemically attach platinum(IV). This construct can circulate safely through the blood stream and readily enter tumor cells, which take up the nanoparticles and their payload by engulfing them in tiny pockets of cell membrane called endosomes. The acidic environment inside the endosome is such that platinum(IV) undergoes a chemical reaction that converts it into platinum(II), the highly toxic form of this element.

When administered to four different kinds of tumor cells, the nanoparticle-platinum(IV) construct was more toxic than an equivalent dose of cisplatin. But more importantly, the platinum(IV) compound itself, unattached to a nucleic acid-decorated gold nanoparticle, was unable to kill any of the treated cancer cells. The investigators then showed that the nanoparticle-delivered platinum(IV) compound killed the treated tumor cells in the same way that cisplatin does.

This work, which is detailed in a paper titled, "Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads," was supported by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.

As part of the Center for Strategic Scientific Initiatives which is led by NCI Deputy Director Dr. Anna Barker, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
(301) 496-1550

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Ultra-flat circuits will have unique properties: Rice University lab studies 2-D hybrids to see how they differ from common electronics July 25th, 2016

Attosecond physics: Mapping electromagnetic waveforms July 25th, 2016

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Possible Futures

Designing climate-friendly concrete, from the nanoscale up: New understanding of concrete’s properties could increase lifetime of the building material, decrease emissions July 25th, 2016

Ultra-flat circuits will have unique properties: Rice University lab studies 2-D hybrids to see how they differ from common electronics July 25th, 2016

Attosecond physics: Mapping electromagnetic waveforms July 25th, 2016

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Nanomedicine

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Announcements

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

XEI Scientific Partners with Electron Microscopy Sciences to Promote and Sell its Products in North and South America July 25th, 2016

Nanobiotechnology

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

New reaction for the synthesis of nanostructures July 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic