Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > JEOL Introduces a New Correlative Microscopy Tool for Observing Biological Samples and Materials in Atmosphere

New JEOL ClairScope ™ Correlative Microscope
New JEOL ClairScope ™ Correlative Microscope

Abstract:
New ClairScope tm Combines Atmospheric Scanning Electron Microscope (ASEM) with Light Microscope

JEOL Introduces a New Correlative Microscopy Tool for Observing Biological Samples and Materials in Atmosphere

Peabody, MA | Posted on October 21st, 2009

JEOL, a global leader in the development and manufacture of scanning and transmission electron microscopes, introduces ClairScopetm, a first-of-its kind correlative microscopy tool that combines a high-end Light Microscope (LM) with a high-resolution Atmospheric Scanning Electron Microscope (ASEM). The new JEOL ClairScope enables uncompromised observation of samples in their native state using both LM and ASEM, significantly reducing sample preparation time and allowing dynamic observation of real time processes. The atmospheric SEM allows high resolution observation of wet biological samples such as cultured cells and imaging of materials samples in liquids.

High Resolution Observation of Life Science and Materials Experiments As They Occur

The ClairScope's unique specimen dish makes it possible to add reagents, drugs, and other substances to the sample in order to perform experiments and observe reactions in both liquid and gas environments. For the first time, life science researchers can harness the powerful imaging capability of the SEM to observe biological processes such as platelet generation, distribution of sugar chains, and microbe growth. Materials scientists will be able to observe and record crystallization, electrochemical reactions, emulsion technology, self-assemblies, and dendrite growth as they occur.

Integrating LM and SEM with Control of Sample Environment

Researchers can control the specimen's environment and stop processes at specific points in the experiment using the ClairScope to observe samples at atmospheric pressure in liquid or gas. The wide-field light microscope with emersion lens is co-axially aligned with the inverted electron column making it easy to switch between the light microscope and the electron microscope without repositioning the specimen dish. The specimen dish features an ultrathin SiN film window that allows transmission of the electron beam for SEM imaging while the sample is open to atmospheric pressure.

"The ClairScope features a high quality wide-field microscope integrated with the ASEM. When we combine SEM and LM, there is no compromise in working distance and there are no issues with vacuum in the ClairScope," said Mitsuo Suga, ClairScope Project Leader.

Atmospheric SEM vs. Environmental SEM

The development of an Atmospheric SEM offers greater opportunities to observe samples in their native state than previously possible. "The advantage of this ASEM over an ESEM is that we can look at samples at room temperature and at atmosphere and we can watch those processes dynamically," said JEOL USA Product Manager Donna Guarrera. "No lengthy drying processes, protective coating, or freezing of wet samples such as cultured cells, is required."

The new ClairScope is being introduced at the Society for Neuroscience meeting in Chicago this week, where more than 30,000 scientists are involved in cutting edge research.

####

About JEOL USA, Inc.
JEOL is a world leader in electron optical equipment and instrumentation for high-end scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., is a wholly owned subsidiary of JEOL, Ltd., Japan, and was incorporated in the United States in 1962. The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

For more information about JEOL USA, Inc. or any JEOL products, visit www.jeolusa.com, or call 978-535-5900.

For more information, please click here

Contacts:
Patricia Corkum
978-536-2273

Copyright © JEOL USA, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

Self Assembly

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

Nanotubes that build themselves April 14th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Materials/Metamaterials

Record high photoconductivity for new metal-organic framework material December 15th, 2017

A new product to help combat mouldy walls, thanks to technology developed at the ICN2 December 14th, 2017

Creating a new kind of metallic glass December 7th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

Announcements

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

Tools

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

JPK Instruments announce partnership with Swiss company, Cytosurge AG. The partnership makes Cytosurge’s FluidFM® technology available on the JPK NanoWizard® AFM platform December 8th, 2017

Researchers advance technique to detect ovarian cancer: Rice, MD Anderson use fluorescent carbon nanotube probes to achieve first in vivo success November 30th, 2017

Nanobiotechnology

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project