Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > JEOL Introduces a New Correlative Microscopy Tool for Observing Biological Samples and Materials in Atmosphere

New JEOL ClairScope  Correlative Microscope
New JEOL ClairScope Correlative Microscope

Abstract:
New ClairScope tm Combines Atmospheric Scanning Electron Microscope (ASEM) with Light Microscope

JEOL Introduces a New Correlative Microscopy Tool for Observing Biological Samples and Materials in Atmosphere

Peabody, MA | Posted on October 21st, 2009

JEOL, a global leader in the development and manufacture of scanning and transmission electron microscopes, introduces ClairScopetm, a first-of-its kind correlative microscopy tool that combines a high-end Light Microscope (LM) with a high-resolution Atmospheric Scanning Electron Microscope (ASEM). The new JEOL ClairScope enables uncompromised observation of samples in their native state using both LM and ASEM, significantly reducing sample preparation time and allowing dynamic observation of real time processes. The atmospheric SEM allows high resolution observation of wet biological samples such as cultured cells and imaging of materials samples in liquids.

High Resolution Observation of Life Science and Materials Experiments As They Occur

The ClairScope's unique specimen dish makes it possible to add reagents, drugs, and other substances to the sample in order to perform experiments and observe reactions in both liquid and gas environments. For the first time, life science researchers can harness the powerful imaging capability of the SEM to observe biological processes such as platelet generation, distribution of sugar chains, and microbe growth. Materials scientists will be able to observe and record crystallization, electrochemical reactions, emulsion technology, self-assemblies, and dendrite growth as they occur.

Integrating LM and SEM with Control of Sample Environment

Researchers can control the specimen's environment and stop processes at specific points in the experiment using the ClairScope to observe samples at atmospheric pressure in liquid or gas. The wide-field light microscope with emersion lens is co-axially aligned with the inverted electron column making it easy to switch between the light microscope and the electron microscope without repositioning the specimen dish. The specimen dish features an ultrathin SiN film window that allows transmission of the electron beam for SEM imaging while the sample is open to atmospheric pressure.

"The ClairScope features a high quality wide-field microscope integrated with the ASEM. When we combine SEM and LM, there is no compromise in working distance and there are no issues with vacuum in the ClairScope," said Mitsuo Suga, ClairScope Project Leader.

Atmospheric SEM vs. Environmental SEM

The development of an Atmospheric SEM offers greater opportunities to observe samples in their native state than previously possible. "The advantage of this ASEM over an ESEM is that we can look at samples at room temperature and at atmosphere and we can watch those processes dynamically," said JEOL USA Product Manager Donna Guarrera. "No lengthy drying processes, protective coating, or freezing of wet samples such as cultured cells, is required."

The new ClairScope is being introduced at the Society for Neuroscience meeting in Chicago this week, where more than 30,000 scientists are involved in cutting edge research.

####

About JEOL USA, Inc.
JEOL is a world leader in electron optical equipment and instrumentation for high-end scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., is a wholly owned subsidiary of JEOL, Ltd., Japan, and was incorporated in the United States in 1962. The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

For more information about JEOL USA, Inc. or any JEOL products, visit www.jeolusa.com, or call 978-535-5900.

For more information, please click here

Contacts:
Patricia Corkum
978-536-2273

Copyright © JEOL USA, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists discover new 'boat' form of promising semiconductor: GeSe Uncommon form attenuates semiconductor's band gap size March 23rd, 2017

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Rare-earths become water-repellent only as they age March 22nd, 2017

Pulverizing e-waste is green, clean -- and cold: Rice, Indian Institute researchers use cryo-mill to turn circuit boards into separated powders March 21st, 2017

Self Assembly

Nanocages for gold particles: what is happening inside? March 16th, 2017

Most Complex Nanoparticle Crystal Ever Made by Design: Possible applications include controlling light, capturing pollutants, delivering therapeutics March 2nd, 2017

Molecular phenomenon discovered by advanced NMR facility: Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Wa February 22nd, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Materials/Metamaterials

Rare-earths become water-repellent only as they age March 22nd, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Next-gen steel under the microscope March 18th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Announcements

Scientists discover new 'boat' form of promising semiconductor: GeSe Uncommon form attenuates semiconductor's band gap size March 23rd, 2017

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Rare-earths become water-repellent only as they age March 22nd, 2017

Pulverizing e-waste is green, clean -- and cold: Rice, Indian Institute researchers use cryo-mill to turn circuit boards into separated powders March 21st, 2017

Tools

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Next-gen steel under the microscope March 18th, 2017

Novel nozzle saves crystals: Double flow concept widens spectrum for protein crystallography March 17th, 2017

Nanobiotechnology

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Biophysicists propose new approach for membrane protein crystallization March 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project