Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCSC nanopore project wins $1.1 million NIH grant

Abstract:
The National Human Genome Research Institute (NHGRI) has awarded a $1.1 million grant to researchers in the Jack Baskin School of Engineering at UC Santa Cruz to support their work on nanopore technology for analyzing DNA.

UCSC nanopore project wins $1.1 million NIH grant

Santa Cruz, CA | Posted on October 14th, 2009

Led by biomolecular engineers Mark Akeson and David Deamer, the UCSC nanopore group has pioneered a technology based on a tiny pore in a membrane, called a "nanopore" because it is just 1.5 nanometers wide at its narrowest point. The nanopore is formed by a self-assembling protein complex called an ion channel and is just big enough to allow a single strand of DNA to pass through. Researchers use the nanopore device to obtain precise measurements of DNA structure and dynamics as the molecule passes through the pore.

A primary goal of the project is to develop nanopore technology as a fast and inexpensive method for DNA sequencing. Medical diagnosis and treatment is being revolutionized by tools that enable doctors to quickly obtain detailed genetic information about their patients. That genetic information is encoded in the sequence of nucleotide subunits in DNA molecules. Despite many advances in sequencing technology, however, DNA sequencing is still too expensive and time-consuming for routine clinical use.

Akeson, a professor of biomolecular engineering, said the UCSC nanopore group has made progress recently by coupling DNA-binding enzymes to the nanopore. DNA polymerases are enzymes involved in the replication of DNA in cells. When coupled to the nanopore, the enzymes control the movement of the DNA molecule through the pore.

"We are borrowing from nature, which has developed this molecular machinery to replicate DNA in cells," Akeson said. "The polymerase controls the rate at which the DNA is processed through the nanopore sensor, operating in the range of 1 to 100 milliseconds per nucleotide. It also regulates the distance the DNA molecule moves, so that it advances one nucleotide at a time."

In the work funded by the NHGRI grant, the researchers are focusing on experiments to measure the effects of voltage and other variables on how efficiently the nanopore system can control and process long DNA molecules (up to 2,500 nucleotides in length). The new grant was funded through the economic stimulus bill (the American Recovery and Reinvestment Act).

Since its beginnings in 1996, the UCSC nanopore project has grown into a large collaborative effort within the Baskin School of Engineering. In addition to Akeson and Deamer, a research professor of biomolecular engineering, the group now includes William Dunbar, assistant professor of computer engineering; Hongyun Wang, professor of applied math and statistics; and senior investigators Kate Lieberman, Felix Olasagasti, and Robin Abu-Shumays. Graduate students Noah Wilson, Daniel Garalde, and Nick Hurt are also associated with the nanopore group, as are six undergraduates.

"Some of the most promising work we do is coming from the undergrads in our lab," Akeson said. "One of our laboratories and four of our state-of-the-art nanopore devices are currently devoted to experiments by these students."

The nanopore technology developed at UCSC has been licensed by Oxford Nanopore Technologies of Oxford, U.K., which is developing nanopore technology for DNA sequencing and other potential applications. The UCSC Office for Management of Intellectual Property was instrumental in negotiating a favorable agreement with the company, Akeson said.

####

For more information, please click here

Contacts:
Tim Stephens
(831) 459-2495


Note to reporters:
You may contact
Mark Akeson
(831) 459-5157

Copyright © UCSC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Self Assembly

Revealed: How bacteria drill into our cells and kill them December 2nd, 2014

Live Images from the Nano-cosmos: Researchers watch layers of football molecules grow November 5th, 2014

Outsmarting Thermodynamics in Self-assembly of Nanostructures: Berkeley Lab reports method for symmetry-breaking in feedback-driven self-assembly of optical metamaterials November 4th, 2014

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Nanomedicine

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Announcements

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Patents/IP/Tech Transfer/Licensing

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Chemists Fabricate Novel Rewritable Paper: An attractive alternate to regular paper, UC Riverside-developed technology helps address increasing problems in environment and resource sustainability December 2nd, 2014

Dicerna Announces License Agreement with Tekmira to Advance Dicerna’s PH1 Development Program November 17th, 2014

First genetic-based tool to detect circulating cancer cells in blood: NanoFlares light up individual cells if breast cancer biomarker is present November 17th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

“Line dancing bacteria win the 2014 Dolomite and Lab on a Chip Video Competition” December 16th, 2014

Lifeboat Foundation gives 2014 Guardian Award to Elon Musk December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE