Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UCSC nanopore project wins $1.1 million NIH grant

Abstract:
The National Human Genome Research Institute (NHGRI) has awarded a $1.1 million grant to researchers in the Jack Baskin School of Engineering at UC Santa Cruz to support their work on nanopore technology for analyzing DNA.

UCSC nanopore project wins $1.1 million NIH grant

Santa Cruz, CA | Posted on October 14th, 2009

Led by biomolecular engineers Mark Akeson and David Deamer, the UCSC nanopore group has pioneered a technology based on a tiny pore in a membrane, called a "nanopore" because it is just 1.5 nanometers wide at its narrowest point. The nanopore is formed by a self-assembling protein complex called an ion channel and is just big enough to allow a single strand of DNA to pass through. Researchers use the nanopore device to obtain precise measurements of DNA structure and dynamics as the molecule passes through the pore.

A primary goal of the project is to develop nanopore technology as a fast and inexpensive method for DNA sequencing. Medical diagnosis and treatment is being revolutionized by tools that enable doctors to quickly obtain detailed genetic information about their patients. That genetic information is encoded in the sequence of nucleotide subunits in DNA molecules. Despite many advances in sequencing technology, however, DNA sequencing is still too expensive and time-consuming for routine clinical use.

Akeson, a professor of biomolecular engineering, said the UCSC nanopore group has made progress recently by coupling DNA-binding enzymes to the nanopore. DNA polymerases are enzymes involved in the replication of DNA in cells. When coupled to the nanopore, the enzymes control the movement of the DNA molecule through the pore.

"We are borrowing from nature, which has developed this molecular machinery to replicate DNA in cells," Akeson said. "The polymerase controls the rate at which the DNA is processed through the nanopore sensor, operating in the range of 1 to 100 milliseconds per nucleotide. It also regulates the distance the DNA molecule moves, so that it advances one nucleotide at a time."

In the work funded by the NHGRI grant, the researchers are focusing on experiments to measure the effects of voltage and other variables on how efficiently the nanopore system can control and process long DNA molecules (up to 2,500 nucleotides in length). The new grant was funded through the economic stimulus bill (the American Recovery and Reinvestment Act).

Since its beginnings in 1996, the UCSC nanopore project has grown into a large collaborative effort within the Baskin School of Engineering. In addition to Akeson and Deamer, a research professor of biomolecular engineering, the group now includes William Dunbar, assistant professor of computer engineering; Hongyun Wang, professor of applied math and statistics; and senior investigators Kate Lieberman, Felix Olasagasti, and Robin Abu-Shumays. Graduate students Noah Wilson, Daniel Garalde, and Nick Hurt are also associated with the nanopore group, as are six undergraduates.

"Some of the most promising work we do is coming from the undergrads in our lab," Akeson said. "One of our laboratories and four of our state-of-the-art nanopore devices are currently devoted to experiments by these students."

The nanopore technology developed at UCSC has been licensed by Oxford Nanopore Technologies of Oxford, U.K., which is developing nanopore technology for DNA sequencing and other potential applications. The UCSC Office for Management of Intellectual Property was instrumental in negotiating a favorable agreement with the company, Akeson said.

####

For more information, please click here

Contacts:
Tim Stephens
(831) 459-2495


Note to reporters:
You may contact
Mark Akeson
(831) 459-5157

Copyright © UCSC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nano Global, Arm Collaborate on Artificial Intelligence Chip to Drive Health Revolution by Capturing and Analyzing Molecular Data in Real Time November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Govt.-Legislation/Regulation/Funding/Policy

EC Project Aims at Creating and Commercializing Cyber-Physical-System Solutions November 14th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3ís significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Leti Joins DARPA-Funded Project to Develop Implantable Device for Restoring Vision November 9th, 2017

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs November 8th, 2017

Self Assembly

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

Nanotubes that build themselves April 14th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Nanomedicine

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3ís significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Arrowhead to Present at 29th Annual Piper Jaffray Healthcare Conference November 14th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Announcements

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nano Global, Arm Collaborate on Artificial Intelligence Chip to Drive Health Revolution by Capturing and Analyzing Molecular Data in Real Time November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Patents/IP/Tech Transfer/Licensing

Picosunís ALD nanolaminates improve lifetime and reliability of electronic circuit boards October 24th, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Nanoparticles limit damage in spinal cord injury: Injection after an injury reduces inflammation and scarring September 6th, 2017

More durable, less expensive fuel cells: University of Delaware researchers have developed a new technology that could speed up the commercialization of fuel cell vehicles September 5th, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

Oxford Instruments announces winner of the 2017 Sir Martin Wood Prize for Japan November 14th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs November 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project