Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCSC nanopore project wins $1.1 million NIH grant

Abstract:
The National Human Genome Research Institute (NHGRI) has awarded a $1.1 million grant to researchers in the Jack Baskin School of Engineering at UC Santa Cruz to support their work on nanopore technology for analyzing DNA.

UCSC nanopore project wins $1.1 million NIH grant

Santa Cruz, CA | Posted on October 14th, 2009

Led by biomolecular engineers Mark Akeson and David Deamer, the UCSC nanopore group has pioneered a technology based on a tiny pore in a membrane, called a "nanopore" because it is just 1.5 nanometers wide at its narrowest point. The nanopore is formed by a self-assembling protein complex called an ion channel and is just big enough to allow a single strand of DNA to pass through. Researchers use the nanopore device to obtain precise measurements of DNA structure and dynamics as the molecule passes through the pore.

A primary goal of the project is to develop nanopore technology as a fast and inexpensive method for DNA sequencing. Medical diagnosis and treatment is being revolutionized by tools that enable doctors to quickly obtain detailed genetic information about their patients. That genetic information is encoded in the sequence of nucleotide subunits in DNA molecules. Despite many advances in sequencing technology, however, DNA sequencing is still too expensive and time-consuming for routine clinical use.

Akeson, a professor of biomolecular engineering, said the UCSC nanopore group has made progress recently by coupling DNA-binding enzymes to the nanopore. DNA polymerases are enzymes involved in the replication of DNA in cells. When coupled to the nanopore, the enzymes control the movement of the DNA molecule through the pore.

"We are borrowing from nature, which has developed this molecular machinery to replicate DNA in cells," Akeson said. "The polymerase controls the rate at which the DNA is processed through the nanopore sensor, operating in the range of 1 to 100 milliseconds per nucleotide. It also regulates the distance the DNA molecule moves, so that it advances one nucleotide at a time."

In the work funded by the NHGRI grant, the researchers are focusing on experiments to measure the effects of voltage and other variables on how efficiently the nanopore system can control and process long DNA molecules (up to 2,500 nucleotides in length). The new grant was funded through the economic stimulus bill (the American Recovery and Reinvestment Act).

Since its beginnings in 1996, the UCSC nanopore project has grown into a large collaborative effort within the Baskin School of Engineering. In addition to Akeson and Deamer, a research professor of biomolecular engineering, the group now includes William Dunbar, assistant professor of computer engineering; Hongyun Wang, professor of applied math and statistics; and senior investigators Kate Lieberman, Felix Olasagasti, and Robin Abu-Shumays. Graduate students Noah Wilson, Daniel Garalde, and Nick Hurt are also associated with the nanopore group, as are six undergraduates.

"Some of the most promising work we do is coming from the undergrads in our lab," Akeson said. "One of our laboratories and four of our state-of-the-art nanopore devices are currently devoted to experiments by these students."

The nanopore technology developed at UCSC has been licensed by Oxford Nanopore Technologies of Oxford, U.K., which is developing nanopore technology for DNA sequencing and other potential applications. The UCSC Office for Management of Intellectual Property was instrumental in negotiating a favorable agreement with the company, Akeson said.

####

For more information, please click here

Contacts:
Tim Stephens
(831) 459-2495


Note to reporters:
You may contact
Mark Akeson
(831) 459-5157

Copyright © UCSC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nitrogen Doped Graphene Characterized by Iranian, Russian, German Scientists October 21st, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

HP Supercomputer at NREL Garners Top Honor October 19th, 2014

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Self Assembly

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Nanomedicine

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Announcements

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nitrogen Doped Graphene Characterized by Iranian, Russian, German Scientists October 21st, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

Patents/IP/Tech Transfer/Licensing

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

Aculon Receives Patent for Application of Enhanced Bonding Layers on Titanium October 9th, 2014

harmaEngine will join Nanobiotix’ pivotal trial for NBTXR3 in Soft Tissue Sarcoma to accelerate its development in Asia-Pacific: PharmaEngine to make milestone payment to Nanobiotix in October 2014 to recognize the value created October 8th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

QD Vision Wins Prestigious Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency October 16th, 2014

Beyond LEDs: Brighter, new energy-saving flat panel lights based on carbon nanotubes - Planar light source using a phosphor screen with highly crystalline single-walled carbon nanotubes (SWCNTs) as field emitters demonstrates its potential for energy-efficient lighting device October 14th, 2014

Unique catalysts for hydrogen fuel cells synthesized in ordinary kitchen microwave oven October 14th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE