Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > High-sensitivity bone marrow aspiration technology enhances leukemia cell detection

This is Richard S. Larson, M.D., Ph.D., vice president for translation research at the University of New Mexico Health Science Center.

Credit: Richard S. Larson, M.D., Ph.D.
This is Richard S. Larson, M.D., Ph.D., vice president for translation research at the University of New Mexico Health Science Center.

Credit: Richard S. Larson, M.D., Ph.D.

Abstract:
Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow.

Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. Results of this proof-of-concept study are published in Cancer Research, a journal of the American Association for Cancer Research.

High-sensitivity bone marrow aspiration technology enhances leukemia cell detection

Philadelphia, PA | Posted on October 6th, 2009

"This promises to significantly enhance the detection for residual disease in leukemia and other cancers," said lead scientist Richard S. Larson, M.D., Ph.D., vice president for translation research at the University of New Mexico Health Science Center. "Coupling nanotechnology can be employed in common techniques to enhance its utility."

These findings are a result of a collaborative research effort between Senior Scientific, LLC, and the University of New Mexico. The study was funded by a small business innovation grant awarded by the National Cancer Institute.

Previous studies have indicated that the magnetic needle can collect approximately 80 percent of leukemia cells in a bone marrow sample in a matter of minutes, according to Edward R. Flynn, Ph.D., president and CEO of Senior Scientific, LLC.

The scientists developed this magnetic marrow biopsy needle in an effort to target tumor cells with nanoparticles and then preferentially extract the tumor cells with a magnetic needle. They used anti-CD34 antibody loaded magnetic nanoparticles to detect CD34+ cells as an indicator of leukemia. To quantify the cells recovered, they coupled this nanoparticle-mediated fishing for leukemic cells with SQUID.

SQUID enhanced the sensitivity of measuring minimal residual disease over standard pathology methods for patients undergoing chemotherapy.

"This result will determine more precisely the effect of the chemotherapy and will help to ascertain proper dosage or termination of treatment for patients," said Flynn.

Furthermore, Larson said that SQUID will work well with current technologies to improve the detection of leukemia cells in the bone marrow. Chi Van Dang, M.D., Ph.D., professor of medicine, cell biology, oncology and pathology, and vice dean for research at the Johns Hopkins University School of Medicine, believes this approach is quite different from the current standard. He suggested that the sensitivity compared to polymerase chain reaction still needs to be determined.

"In the case of leukemias without clear genetic markers, the magnetic needle could be useful," said Dang, who was not associated with this study, but is an editorial board member for Cancer Research. "It is possible that this technology could be used to detect cancer stem cells in general, if the proper antibodies with appropriate specificity are available."

Senior Scientific, LLC is currently participating in follow-up studies to increase the efficiency of the magnetic needle further through advanced magnet configurations and theoretical calculations.


Subscribe to the AACR RSS News Feed: feeds.feedburner.com/aacr

Subscribe to the Cancer Research RSS Feed: cancerres.aacrjournals.org/rss/recent.xml

####

About American Association for Cancer Research
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes 30,000 basic, translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and nearly 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants, research fellowship and career development awards. The AACR Annual Meeting attracts more than 16,000 participants who share the latest discoveries and developments in the field. Special conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment and patient care. The AACR publishes six major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; and Cancer Prevention Research. The AACR also publishes CR, a magazine for cancer survivors and their families, patient advocates, physicians and scientists. CR provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship and advocacy.

For more information, please click here

Contacts:
Tara Yates

267-646-0558

Copyright © American Association for Cancer Research

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Nanomedicine

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Neutrophil nanosponges soak up proteins that promote rheumatoid arthritis September 3rd, 2018

Discoveries

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Announcements

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Quantum nanoscience

September 5th, 2018

A Novel Graphene Quantum Dot Structure Takes the Cake August 24th, 2018

How hot is Schrödinger's coffee? August 15th, 2018

Breaking down the Wiedemann-Franz law: In a study exploring the coupling between heat and particle currents in a gas of strongly interacting atoms, physicists at ETH Zurich find puzzling behaviours August 10th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project