Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCF Team Developing Tool Kit to Help Diagnose Dementia

Associate Professor Hyoung Jin Cho (right) partnered with UCF colleague Sudipta Seal (not pictured).
Associate Professor Hyoung Jin Cho (right) partnered with UCF colleague Sudipta Seal (not pictured).

Abstract:
With the risk of developing dementia growing at an alarming pace, a University of Central Florida research team is working with the Boston University School of Medicine to develop a miniature diagnostic toolkit in the hopes of stimulating earlier detection and treatment.

UCF Team Developing Tool Kit to Help Diagnose Dementia

Orlando, FL | Posted on October 1st, 2009

The collaborative research project, funded by the National Science Foundation for up to $600,000 over three years, will use nanoparticles on a chip about the size of a credit card to detect damaging levels of oxygen byproducts in the central nervous system.

The byproducts, known as reactive oxygen species (ROS), are major contributors to serious neurodegenerative diseases, including Alzheimer's and Parkinson's.

The development of new analytical tools for speeding up diagnosis and treatment of these disorders is critical if we hope to slow their growth, said lead researcher Hyoung Jin Cho, an associate professor of Mechanical, Materials and Aerospace Engineering at the University of Central Florida and a researcher at UCF's NanoScience Technology Center.

The number of people with dementia, which is the primary precursor to Alzheimer's, will almost double every 20 years, reaching 65.7 million in 2030 and 115.4 million in 2050, according to the 2009 World Alzheimer Report from Alzheimer's Disease International. The report, issued last week in recognition of World Alzheimer's Day, calls for making the fight against the disease a national and global priority.

"This research shows significant potential for better understanding the role of ROS in neurodegenerative diseases," said Cho. "Once we have a clearer understanding of the role of ROS, we may be able to address more effective treatments."

Existing tests have several drawbacks. They are only able to detect limited numbers of significant byproducts at a time; they require time-consuming and labor-intensive processing; and they don't work quickly enough to keep up with the short lifespan of most of the byproducts.

Cho has previously developed a microfluidic mixer and a miniaturized electrochemical sensor for "lab on a chip" applications that would allow scientists to perform multiple analyses on one miniaturized chip. He said the ROS assessment tool will be developed on a similar platform.

What will make the ROS detector unique is the use of nanoparticles to help detect the high oxidative stress that has been identified as one of the earliest indicators of Alzheimer's and Parkinson's diseases.

Cho partnered with Sudipta Seal, director of UCF's NanoScience Technology and Advanced Materials Processing and Analysis centers, who has studied rare earth cerium oxide nanoparticles for years. Seal has found them to be effective at everything from treating glaucoma to cleansing fly ash from smokestacks.

Because the nanoparticles behave like an antioxidant, protecting cells from oxidative stress, they can effectively serve as an indicator of ROS, Seal said.

Together with Diego Diaz, a NanoScience Technology Center and Department of Chemistry faculty member, the researchers are collaborating with a group led by Lee Goldstein, an associate professor at the Boston University School of Medicine.

UCF's share of the NSF funding is $346,000.

####

About University of Central Florida
UCF Stands For Opportunity --The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 52,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

Contacts:
Zenaida Gonzalez Kotala
News & Information
407-823-6120

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Nanomedicine

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Sensors

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Graphenea opens US branch October 16th, 2014

IRLYNX and CEA-Leti to Streamline New CMOS-based Infrared Sensing Modules Dedicated to Human-activities Characterization October 15th, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Nanobiotechnology

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE