Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Acoustic tweezers can position tiny objects

"Acoustic tweezers" enable flexible on-chip manipulation and patterning of cells using standing surface acoustic waves.

Credit: Tony Jun Huang, Jinjie Shi, Penn State
"Acoustic tweezers" enable flexible on-chip manipulation and patterning of cells using standing surface acoustic waves. Credit: Tony Jun Huang, Jinjie Shi, Penn State

Abstract:
Manipulating tiny objects like single cells or nanosized beads often requires relatively large, unwieldy equipment, but now a system that uses sound as a tiny tweezers can be small enough to place on a chip, according to Penn State engineers.

Acoustic tweezers can position tiny objects

University Park, PA | Posted on September 1st, 2009

"Current methods for moving individual cells or tiny beads include such devices as optical tweezers, which require a lot of energy and could damage or even kill live cells," said Tony Jun Huang, assistant professor of engineering science and mechanics. "Acoustic tweezers are much smaller than optical tweezers and use 500,000 times less energy."

While optical tweezers are large and expensive, acoustic tweezers are smaller than a dime, small enough to fabricate on a chip using standard chip manufacturing techniques. They can also manipulate live cells without damaging or killing them.

Acoustic tweezers differ from eyebrow tweezers in that they position many tiny objects simultaneously and place them equidistant from each other in either parallel lines or on a grid. The grid configuration is probably the most useful for biological applications where researchers can place stem cells on a grid for testing or skin cells on a grid to grow new skin. This allows investigators to see how any type of cell grows.

"Acoustic tweezers are not just useful in biology," said Huang. "They can be used in physics, chemistry and materials science to create patterns of nanoparticles for coatings or to etch surfaces."

Acoustic tweezers work by setting up a standing surface acoustic wave. If two sound sources are placed opposite each other and each emits the same wavelength of sound, there will be a location where the opposing sounds cancel each other. This location can be considered a trough. Because sound waves have pressure, they can push very small objects, so a cell or nanoparticle will move with the sound wave until it reaches the trough where there is no longer movement. The particle or cell will stop and "fall" into the trough.

If the sound comes from two parallel sound sources facing each other, the troughs form a line or series of lines. If the sound sources are at right angles to each other, the troughs form an evenly spaced set of rows and columns like a checkerboard. Here too, the particles are pushed until they reach the location where the sound is no longer moving.

The acoustic tweezers are manufactured by fabricating an interdigital transducer onto a piezoelectric chip surface. These transducers are the source of the sound. Next, using standard photolithography, microchannels are fabricated in which a small amount of liquid with the cells or particles can move around freely. These microchannels were bonded to the chip to create the area for particle movement.

To test their device, the researchers, who include Jinjie Shi, Daniel Ahmed and Sz-Chin Steven Lin, graduate students, engineering science and mechanics; Xiaole Mao, graduate student in bioengineering, and Aitan Lawit, undergraduate in engineering science and mechanics, used Dragon Green fluorescent polystyrene beads about 1.9 micrometers in diameter. They then used cows red blood cells and the single cell bacteria E. coli to test the acoustic tweezers.

"The results verify the versatility of our technique as the two groups of cells differ significantly in both shape (spherical beads vs. rod-shaped E. coli) and size," the researchers reported in a recent issue of Lab on a Chip. They note that the patterning performance is independent of the particle's electrical, magnetic and optical properties.

"Most cells or particles patterned in a few seconds," said Huang. "The energy used is very low and the acoustic tweezers should not damage cells at all. Because they have different properties, the acoustic tweezers could also separate live from dead cells, or different types of particles."

Acoustic tweezers technology has significant advantages over existing technologies because of its versatility, miniaturization, power consumption and technical simplicity. Huang expects it to become a powerful tool for many applications such as tissue engineering, cell studies, and drug screening and discovery.

The National Science Foundation supported this work.




####

About Penn State
Penn State is a multi-campus public research university that improves the lives of the people of Pennsylvania, the nation, and the world through integrated, high-quality programs in teaching, research, and service.

Our instructional mission includes undergraduate, graduate, professional, and continuing and distance education informed by scholarship and research.

Our research, scholarship, and creative activities promote human and economic development through the expansion of knowledge and its applications in the natural and applied sciences, social sciences, arts, humanities, and professions. As Pennsylvania's land-grant university, we also hold a unique responsibility to provide access, outreach, and public service to support the citizens of the Commonwealth and beyond. We engage in collaborative activities with industrial, educational, and agricultural partners here and abroad to generate, disseminate, integrate, and apply knowledge.

For more information, please click here

Contacts:
A'ndrea Elyse Messer

814-865-9481

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

INVECAS to Enable ASIC Designs for Tomorrows Intelligent Systems on GLOBALFOUNDRIES' FDX Technology: INVECAS to Collaborate with GLOBALFOUNDRIES to Provide IP and End-to-End ASIC Design Services on 22FDX and 12FDX Technologies September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Chemistry

Chains of nanogold forged with atomic precision September 23rd, 2016

Carbon-coated iron catalyst structure could lead to more-active fuel cells September 15th, 2016

Researchers build world's largest database of crystal surfaces and shapes September 14th, 2016

On-surface chemistry leads to novel products: On-surface chemical Reactions can lead to novel chemical compounds not yet synthesized by solution chemistry. September 13th, 2016

Physics

New breed of optical soliton wave discovered September 9th, 2016

NREL discovery creates future opportunity in quantum computing: Research into perovskites looks beyond material's usage for efficient solar cells September 9th, 2016

Location matters in the self-assembly of nanoclusters: Iowa State University scientists have developed a new formulation to explain an aspect of the self-assembly of nanoclusters on surfaces that has broad applications for nanotechnology September 8th, 2016

University of Akron researchers find thin layers of water can become ice-like at room temperature: Results could lead to an assortment of anti-friction solutions August 30th, 2016

Possible Futures

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Nanosensors could help determine tumors ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Crystalline Fault Lines Provide Pathway for Solar Cell Current: New tomographic AFM imaging technique reveals that microstructural defects, generally thought to be detrimental, actually improve conductivity in cadmium telluride solar cells September 26th, 2016

Chip Technology

INVECAS to Enable ASIC Designs for Tomorrows Intelligent Systems on GLOBALFOUNDRIES' FDX Technology: INVECAS to Collaborate with GLOBALFOUNDRIES to Provide IP and End-to-End ASIC Design Services on 22FDX and 12FDX Technologies September 30th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Researchers at the Catalan Institute of Nanoscience and Nanotechnology show that bending semiconductors generates electricity September 26th, 2016

Mexican scientist in the Netherlands seeks to achieve data transmission ... speed of light September 20th, 2016

Nanomedicine

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Nanosensors could help determine tumors ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Materials/Metamaterials

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Announcements

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

INVECAS to Enable ASIC Designs for Tomorrows Intelligent Systems on GLOBALFOUNDRIES' FDX Technology: INVECAS to Collaborate with GLOBALFOUNDRIES to Provide IP and End-to-End ASIC Design Services on 22FDX and 12FDX Technologies September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Tools

Oxford Instruments systems now facilitate water purification technology September 27th, 2016

Dr Barbara Armbruster promoted to Worldwide Sales and Marketing Director for XEI Scientific September 27th, 2016

Oxford Instruments is Bringing the Nanoworld Together in India once again - 22 - 23 November 2016 | IISc Bangalore September 21st, 2016

Bruker Introduces Complete Commercial AFM-Based SECM Solution: PeakForce SECM Mode Enables Previously Unobtainable Electrochemical Information September 20th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Semiconducting inorganic double helix: New flexible semiconductor for electronics, solar technology and photo catalysis September 15th, 2016

Bringing graphene speakers to the mobile market (video) September 12th, 2016

Nanobiotechnology

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Nanosensors could help determine tumors ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic