Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Quantum dot research could lead to medical advances

Abstract:
Working with atomic-scale particles known as quantum dots, a Missouri University of Science and Technology biologist hopes to develop a new and better way to deliver and monitor proteins, medicine, DNA and other molecules at the cellular level.

Quantum dot research could lead to medical advances

Rolla, MO | Posted on July 24th, 2009

The approach would work much like a virus, but would deliver healing instead of sickness, says Dr. Yue-Wern Huang, associate professor of biological sciences at Missouri S&T. Huang is leading the research effort, which is funded through a $225,000 grant from the National Institutes of Health under the American Recovery and Reinvestment Act.

Huang's research involves constructing tiny vessels of cell-penetrating proteins to transport the quantum dots, along with proteins, medicine or DNA, into the cell and release them. He likens the process to the ancient story of the Trojan Horse, which according to Greek mythology was used to delivered Odysseus and his army into the enemy city of Troy. But in this instance, the vessel is a "protein transduction domain," the cargo consists of biomolecules or other therapeutic agents, and the walled city is the cell.

Essentially, the nontoxic protein transduction domain, or PTD, is derived from a virus that can penetrate the cellular membrane. But instead of spreading sickness, it would spread medicine or DNA.

Quantum dots are fluorescent semiconductor nanocrystals - specks that are only a few nanometers in size - that possess unusual physical and chemical properties, making them attractive as tools for new approaches to medicine. For example, Huang says, the fluorescence of quantum dots does not fade as quickly as that of traditional fluorescent dyes used for tracing or mapping in the body. Moreover, quantum dots have a longer half-life and are more resistant to degradation than traditional fluorescent dyes. Because of these qualities, quantum dots are more effective for detecting cancerous cells and other maladies, Huang says.

"Quantum dots are very photo-stable and they have a very high quantum yield. In other words, you don't need to use very much and it is very easy to detect under the microscope," he says.

Huang and his fellow researchers plan to synthesize cadmium-based fluorescent quantum dots, encapsulated by other elements to render the cadmium harmless, and attach them to protein transduction domain (PTD) materials. The quantum dot/PTD mixture is then combined with the cargo, placed into cell cultures and examined. Though early in the research, Huang says the material populates the cell cultures 10 times faster than a system without PTDs over an hour's time.

According to Huang, this work is unique because it involves the merger of two separate areas of biomedical study - quantum dot research and the PTD delivery system. Before this research, the two disciplines have never been merged, he says.

Huang projects "many potential long-term applications in biomedical areas" to come from this research. They include improvements in medical imaging and monitoring, as well as more efficient delivery of medicines and therapeutic agents at the cellular level and in humans.

Other Missouri S&T researchers working with Huang on the effort are Dr. Jeffrey Winiarz, an assistant professor of chemistry, who is creating the quantum dots, and Dr. Katie Shannon, assistant professor of biological sciences, who is providing bio-imaging expertise.

####

For more information, please click here

Contacts:
Office of Public Relations
1201 N. State St.
105 Campus Support Facility
Rolla, MO 65409-0220
Phone: 573-341-4328
Fax: 573-341-6157

Copyright © Missouri University of Science and Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Nanomedicine

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Discoveries

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Announcements

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Quantum Dots/Rods

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

TCL Launches World’s Most Advanced TV in the World’s Largest Market: New Quantum Dot TVs with Color IQ™ Optics Deliver OLED-Quality Color at a Fraction of the Price December 15th, 2014

Electron pairs on demand: Controlled emission and spatial splitting of electron pairs demonstrated December 4th, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE