Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticle-Based "Chemical Nose" Sniffs Out Cancer Earlier To Improve Treatment Options

Abstract:
Using a "chemical nose" array of nanoparticles and polymers, researchers at the University of Massachusetts Amherst have developed a fundamentally new, more effective way to differentiate not only between healthy and cancerous cells but also between metastatic and nonmetastatic cancer cells. It is a tool that could revolutionize cancer detection and treatment, according to Vincent M. Rotello, Ph.D., M.Phil., and D. Joseph Jerry, Ph.D., M.S., the investigators who led the study.

Nanoparticle-Based "Chemical Nose" Sniffs Out Cancer Earlier To Improve Treatment Options

Bethesda, MD | Posted on July 21st, 2009

Currently, detecting cancer via cell surface biomarkers has taken what is known as the "lock and key" approach. Drawbacks of this method include that foreknowledge of the biomarker is required. Also, as Dr. Rotello explained, a cancer cell often has the same biomarkers on its surface as a healthy cell but in different concentrations—a maddeningly small difference that can be difficult to detect. "You often don't get a big signal for the presence of cancer," he noted. "It's a subtle thing."

He added, "Our new method uses an array of sensors not only to recognize known cancer types but also to signal that abnormal cells are present. That is, the chemical nose can simply tell us something isn't right, like a "check engine" indicator on one's car, although it may never have encountered that type before." Furthermore, the chemical nose can be designed to alert doctors of the most invasive cancer types, those for which early treatment is crucial.

In blinded experiments using four human cancer cell lines (cervical, liver, testes, breast), as well as in three metastatic breast cell lines and normal cells, the new detection technique not only correctly indicated the presence of cancer cells in a sample but also identified primary cancer vs. metastatic disease. An article describing this new chemical nose method of cancer detection appears in the Proceedings of the National Academy of Sciences of the United States of America.

In additional experiments to rule out the possibility that the chemical nose had simply detected individual differences in cells from different donors, the researchers repeated the experiments in skin cells from three groups of cloned BALB/c mice: healthy animals, those with primary cancer, and those with metastatic disease. Once again, it worked. "This result is key," says Dr. Rotello. "It shows that we can differentiate among the three cell types in a single individual using the chemical nose approach."

The investigators designed the new detection system by combining three gold nanoparticles that have special affinity for the surface of chemically abnormal cells plus the polymer para-phenyleneethynylene (PPE). As the check-engine indicator, PPE fluoresces or glows when displaced from the nanoparticle surface.

By adding the PPE-gold nanoparticle construct to human cells incubating in wells on a culture plate, the researchers induced a response called "competitive binding." Cell surfaces bind the nanoparticles, displacing PPE from the surface. This turns on PPE's fluorescent switch. Cells then are identified from the patterns generated by different particle-PPE systems.

Dr. Rotello says the chemical nose approach is so named because it works like a human nose, which is arrayed with hundreds of very selective chemical receptors. These bind with thousands of different chemicals in the air, some more strongly than others, in the endless combinations we encounter. The receptors report instantly to the brain, which recognizes patterns such as, for example, "french fries," or it creates a new smell pattern.

Chemical receptors in the nose and the brain's pattern recognition skills together are incredibly sensitive at detecting subtly different combinations, Dr. Rotello noted. Like a human nose, the chemical version being developed for use in cancer also remembers the patterns experienced, even if only once, and creates a new one when needed.

This work, which was supported in part by the National Cancer Institute, is detailed in the paper "Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays." Investigators from the Georgia Institute of Technology also participated in this study. An abstract of the paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Possible Futures

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

GLOBALFOUNDRIES Demonstrates Industry-Leading 112G Technology for Next-Generation Connectivity Solutions: High bandwidth, low power SerDes IP portfolio enables ‘connected intelligence’ in data centers and networking applications November 15th, 2017

Nanomedicine

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3’s significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Arrowhead to Present at 29th Annual Piper Jaffray Healthcare Conference November 14th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Sensors

The stacked color sensor: True colors meet minimization November 16th, 2017

Promising sensors for submarines, mines and spacecraft: MSU scientists are developing nanostructured gas sensors that would work at room temperature November 10th, 2017

Practical superconducting nanowire single photon detector with record detection efficiency over 90 percent November 9th, 2017

Dendritic fibrous nanosilica: all-in-one nanomaterial for energy, environment and health November 4th, 2017

Announcements

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Nanobiotechnology

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3’s significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Arrowhead to Present at 29th Annual Piper Jaffray Healthcare Conference November 14th, 2017

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs November 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project