Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCF Research Finds Nanoparticles Prevent Cell Damage

Dr. Sudipta Seal in his lab at the University of Central Florida.
Dr. Sudipta Seal in his lab at the University of Central Florida.

Abstract:
University of Central Florida Professor Sudipta Seal and his team have engineered a nanoparticle that appears to prevent cell damage.

UCF Research Finds Nanoparticles Prevent Cell Damage

Orlando, FL | Posted on June 29th, 2009

Seal and his team engineered nanoparticles of cerium oxide (called nanoceria), a material long used in ceramics and fuel cells. In its nanocrystalline form it is non-toxic and appears to work as an antioxidant working to protect cells. Seal's work is recognized by the National Science Foundation this month, which featured him in a Behind the Scenes article at LiveScience.com.

Nanoceria show promise and may protect healthy cells from the damaging effects of radiation given as cancer treatments, and it shows promise for treating arthritis, wound healing, spinal cord injuries and neurodegenerative diseases. In collaboration with researchers at Imperial College London, Seal and his colleagues are also incorporating these nanostructures into bio-scaffolds for tissue engineering.


"It is very exciting," Seal said. "We have found that the nanoceria behave like antioxidants, protecting cells from oxidative stress and they can be fine tuned to potentially deliver medical treatments directly into the cells."

Oxidative stress has been implicated as a cause of arthritis, heart disease and even aging. It also plays a role in several incurable eye diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal degeneration.

Oxidative stress occurs when too many reactive oxygen species (ROS) are present. These powerful molecules are generated by exposure to ionizing radiation and by commonplace reduction-oxidation reactions within cells. (Peroxide and free radicals are two examples of ROS.)

Usually, enzymes known as antioxidants protect cells from oxidative stress by disarming ROS and minimizing their toxic effects. But sometimes, the number of ROS overwhelms a biological system, causing damage to proteins, DNA and other cellular materials.

In the nanocrystalline form Seal and his team engineered, the nanoceria act as powerful antioxidant because its latticework crystal structure can capture oxygen and the material has a large surface area reducing the effects of ROS.

Nanoceria are also able to regenerate their antioxidant abilities, so repeated doses like taking antioxidant vitamins daily, may not be needed, Seal said.

Seal's NSF funded NIRT team includes UCF's Associate Professor William Self, UCF theoretical chemist Asterm Masunov from UCF's Nanoscience and Technology Center, and vision scientist James McGinnis, from the University of Oklahoma Health Sciences Center.

His team's previous work found that nanoceria could also deliver medicine to the retinas of mice with glaucoma.

So far the team has obtained two patents related to the promising nanoceria, and McGinnis has launched a new company to develop medical applications. Meanwhile, Seal and his colleagues continue to investigate the chemical properties of cerium oxide and other rare earth metals and oxides, identifying and investigating various forms with potential applications in medicine and energy. Findings from the ongoing research have been published in several journals including ACS Nano.

Because of its catalytic nature, cerium oxide nanoparticles and their hybrids could also be used efficiently in methanol-ethanol conversion, in the production of hydrogen from sugar cane, for pollution control and as an electrolyte in fuel cells. More research is needed in these areas.


"We have just scratched the surface of what nanoceria can do," he says. "There are endless possibilities."

Along with National Science Foundation award, the National Institutes of Health contributed funding toward this research.

The National Academy of Engineering (NAE) also this month named Seal as one the country's brightest young engineers and will participate in the 15th annual Frontiers of Engineering Symposium in September. He is one of 88 honored and his colleagues include professors and researchers at MIT, Cornell, Microsoft, NASA, Ford Motor Company and John Hopkins.

####

About University of Central Florida
The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 50,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

Contacts:
UCF Professor Seal Sudpita
407-823-5277

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Environment

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

Energy

Nanoparticle technology triples the production of biogas October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Fuel Cells

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

Unique catalysts for hydrogen fuel cells synthesized in ordinary kitchen microwave oven October 14th, 2014

Researchers Pump Up Oil Accumulation in Plant Leaves: Method could greatly boost energy content of crops grown for fuel October 8th, 2014

Platinum meets its match in quantum dots from coal: Rice University's cheap hybrid outperforms rare metal as fuel-cell catalyst October 1st, 2014

Nanobiotechnology

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE