Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

android tablet pc

Home > Press > UCF Research Finds Nanoparticles Prevent Cell Damage

Dr. Sudipta Seal in his lab at the University of Central Florida.
Dr. Sudipta Seal in his lab at the University of Central Florida.

University of Central Florida Professor Sudipta Seal and his team have engineered a nanoparticle that appears to prevent cell damage.

UCF Research Finds Nanoparticles Prevent Cell Damage

Orlando, FL | Posted on June 29th, 2009

Seal and his team engineered nanoparticles of cerium oxide (called nanoceria), a material long used in ceramics and fuel cells. In its nanocrystalline form it is non-toxic and appears to work as an antioxidant working to protect cells. Seal's work is recognized by the National Science Foundation this month, which featured him in a Behind the Scenes article at

Nanoceria show promise and may protect healthy cells from the damaging effects of radiation given as cancer treatments, and it shows promise for treating arthritis, wound healing, spinal cord injuries and neurodegenerative diseases. In collaboration with researchers at Imperial College London, Seal and his colleagues are also incorporating these nanostructures into bio-scaffolds for tissue engineering.

"It is very exciting," Seal said. "We have found that the nanoceria behave like antioxidants, protecting cells from oxidative stress and they can be fine tuned to potentially deliver medical treatments directly into the cells."

Oxidative stress has been implicated as a cause of arthritis, heart disease and even aging. It also plays a role in several incurable eye diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal degeneration.

Oxidative stress occurs when too many reactive oxygen species (ROS) are present. These powerful molecules are generated by exposure to ionizing radiation and by commonplace reduction-oxidation reactions within cells. (Peroxide and free radicals are two examples of ROS.)

Usually, enzymes known as antioxidants protect cells from oxidative stress by disarming ROS and minimizing their toxic effects. But sometimes, the number of ROS overwhelms a biological system, causing damage to proteins, DNA and other cellular materials.

In the nanocrystalline form Seal and his team engineered, the nanoceria act as powerful antioxidant because its latticework crystal structure can capture oxygen and the material has a large surface area reducing the effects of ROS.

Nanoceria are also able to regenerate their antioxidant abilities, so repeated doses like taking antioxidant vitamins daily, may not be needed, Seal said.

Seal's NSF funded NIRT team includes UCF's Associate Professor William Self, UCF theoretical chemist Asterm Masunov from UCF's Nanoscience and Technology Center, and vision scientist James McGinnis, from the University of Oklahoma Health Sciences Center.

His team's previous work found that nanoceria could also deliver medicine to the retinas of mice with glaucoma.

So far the team has obtained two patents related to the promising nanoceria, and McGinnis has launched a new company to develop medical applications. Meanwhile, Seal and his colleagues continue to investigate the chemical properties of cerium oxide and other rare earth metals and oxides, identifying and investigating various forms with potential applications in medicine and energy. Findings from the ongoing research have been published in several journals including ACS Nano.

Because of its catalytic nature, cerium oxide nanoparticles and their hybrids could also be used efficiently in methanol-ethanol conversion, in the production of hydrogen from sugar cane, for pollution control and as an electrolyte in fuel cells. More research is needed in these areas.

"We have just scratched the surface of what nanoceria can do," he says. "There are endless possibilities."

Along with National Science Foundation award, the National Institutes of Health contributed funding toward this research.

The National Academy of Engineering (NAE) also this month named Seal as one the country's brightest young engineers and will participate in the 15th annual Frontiers of Engineering Symposium in September. He is one of 88 honored and his colleagues include professors and researchers at MIT, Cornell, Microsoft, NASA, Ford Motor Company and John Hopkins.


About University of Central Florida
The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 50,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

UCF Professor Seal Sudpita

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014


Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014


Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014


Production of Toxic Ion Nanosorbents with High Sorption Capacity in Iran August 17th, 2014

PerkinElmer to Display Innovative Detection and Informatics Offerings at ACS National Meeting & Exposition Detection, Data Visualization and Analytics for Chemistry Professionals August 8th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Iranian Scientists Use Waste Cotton Fibers to Produce Cellulose Nanoparticles July 29th, 2014


Chemical reaction yields "tapes" of porphin molecules: Flexible tapes from the nanoworld August 13th, 2014

Eco-friendly 'pre-fab nanoparticles' could revolutionize nano manufacturing: UMass Amherst team invents a way to create versatile, water-soluble nano-modules August 13th, 2014

“Active” surfaces control what’s on them: Researchers develop treated surfaces that can actively control how fluids or particles move August 6th, 2014

Used-cigarette butts offer energy storage solution August 5th, 2014

Fuel Cells

Media Advisory: Minister Rempel to Announce Support for Alberta's Nanotechnology Sector June 20th, 2014

Evolution of a Bimetallic Nanocatalyst June 6th, 2014

University of Surrey collaborates with India and Tata Steel to revolutionise renewable energy March 26th, 2014

Novel membrane reveals water molecules will bounce off a liquid surface: Study may lead to more efficient water-desalination systems, fundamental understanding of fluid flow March 16th, 2014


The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Сalculations with Nanoscale Smart Particles August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

The latest news from around the world, FREE

  Premium Products
Only the news you want to read!
 Learn More
University Technology Transfer & Patents
 Learn More
Full-service, expert consulting
 Learn More

Nanotechnology Now Featured Books


The Hunger Project

© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE