Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UCF Research Finds Nanoparticles Prevent Cell Damage

Dr. Sudipta Seal in his lab at the University of Central Florida.
Dr. Sudipta Seal in his lab at the University of Central Florida.

Abstract:
University of Central Florida Professor Sudipta Seal and his team have engineered a nanoparticle that appears to prevent cell damage.

UCF Research Finds Nanoparticles Prevent Cell Damage

Orlando, FL | Posted on June 29th, 2009

Seal and his team engineered nanoparticles of cerium oxide (called nanoceria), a material long used in ceramics and fuel cells. In its nanocrystalline form it is non-toxic and appears to work as an antioxidant working to protect cells. Seal's work is recognized by the National Science Foundation this month, which featured him in a Behind the Scenes article at LiveScience.com.

Nanoceria show promise and may protect healthy cells from the damaging effects of radiation given as cancer treatments, and it shows promise for treating arthritis, wound healing, spinal cord injuries and neurodegenerative diseases. In collaboration with researchers at Imperial College London, Seal and his colleagues are also incorporating these nanostructures into bio-scaffolds for tissue engineering.


"It is very exciting," Seal said. "We have found that the nanoceria behave like antioxidants, protecting cells from oxidative stress and they can be fine tuned to potentially deliver medical treatments directly into the cells."

Oxidative stress has been implicated as a cause of arthritis, heart disease and even aging. It also plays a role in several incurable eye diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal degeneration.

Oxidative stress occurs when too many reactive oxygen species (ROS) are present. These powerful molecules are generated by exposure to ionizing radiation and by commonplace reduction-oxidation reactions within cells. (Peroxide and free radicals are two examples of ROS.)

Usually, enzymes known as antioxidants protect cells from oxidative stress by disarming ROS and minimizing their toxic effects. But sometimes, the number of ROS overwhelms a biological system, causing damage to proteins, DNA and other cellular materials.

In the nanocrystalline form Seal and his team engineered, the nanoceria act as powerful antioxidant because its latticework crystal structure can capture oxygen and the material has a large surface area reducing the effects of ROS.

Nanoceria are also able to regenerate their antioxidant abilities, so repeated doses like taking antioxidant vitamins daily, may not be needed, Seal said.

Seal's NSF funded NIRT team includes UCF's Associate Professor William Self, UCF theoretical chemist Asterm Masunov from UCF's Nanoscience and Technology Center, and vision scientist James McGinnis, from the University of Oklahoma Health Sciences Center.

His team's previous work found that nanoceria could also deliver medicine to the retinas of mice with glaucoma.

So far the team has obtained two patents related to the promising nanoceria, and McGinnis has launched a new company to develop medical applications. Meanwhile, Seal and his colleagues continue to investigate the chemical properties of cerium oxide and other rare earth metals and oxides, identifying and investigating various forms with potential applications in medicine and energy. Findings from the ongoing research have been published in several journals including ACS Nano.

Because of its catalytic nature, cerium oxide nanoparticles and their hybrids could also be used efficiently in methanol-ethanol conversion, in the production of hydrogen from sugar cane, for pollution control and as an electrolyte in fuel cells. More research is needed in these areas.


"We have just scratched the surface of what nanoceria can do," he says. "There are endless possibilities."

Along with National Science Foundation award, the National Institutes of Health contributed funding toward this research.

The National Academy of Engineering (NAE) also this month named Seal as one the country's brightest young engineers and will participate in the 15th annual Frontiers of Engineering Symposium in September. He is one of 88 honored and his colleagues include professors and researchers at MIT, Cornell, Microsoft, NASA, Ford Motor Company and John Hopkins.

####

About University of Central Florida
The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 50,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

Contacts:
UCF Professor Seal Sudpita
407-823-5277

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Possible Futures

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Harris & Harris Group Reports Financial Statements as of June 30, 2015, and Announces a Stock Repurchase Program August 10th, 2015

Molecular trick alters rules of attraction for non-magnetic metals August 5th, 2015

Global Carbon Nanotubes Industry 2015: Acute Market Reports August 4th, 2015

Nanomedicine

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Cervical cancer detection goes portable August 25th, 2015

Antibacterial Nanocomposite Prevents Transmission of Infectious Diseases August 24th, 2015

Announcements

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Environment

Successful boron-doping of graphene nanoribbon August 27th, 2015

Iranian Scientists Utilize Nanomembranes to Purify Wastewater of Olive Oil Plants August 20th, 2015

'Diamonds from the sky' approach turns CO2 into valuable products August 19th, 2015

Sonocatalysts Able to Purify Organic Pollutants of Wastewater August 19th, 2015

Energy

Nanotechnology that will impact the Security & Defense sectors to be discussed at NanoSD2015 conference August 25th, 2015

Industrial Nanotech, Inc. Provides Update On Hospital Project, PCAOB Audit, and New Heat Shield™ Line August 24th, 2015

Novel nanostructures for efficient long-range energy transport August 21st, 2015

Laser-burned graphene gains metallic powers: Rice University scientists find possible replacement for platinum as catalyst August 20th, 2015

Fuel Cells

Laser-burned graphene gains metallic powers: Rice University scientists find possible replacement for platinum as catalyst August 20th, 2015

New spectroscopy technique provides unprecedented insights about the reactions powering fuel cells Nanotech-enabled chip developed at UCLA can analyze chemical reactions more accurately than large machines August 12th, 2015

Pouring fire on fuels at the nanoscale August 9th, 2015

Ultra-thin hollow nanocages could reduce platinum use in fuel cell electrodes July 24th, 2015

Nanobiotechnology

Nanotechnology that will impact the Security & Defense sectors to be discussed at NanoSD2015 conference August 25th, 2015

Louisiana Tech University researchers discover synthesis of a new nanomaterial: Interdisciplinary team creates biocomposite for first time using physiological conditions August 24th, 2015

How UEA research could help build computers from DNA August 19th, 2015

Biophysics: Formation of swarms in nanosystems August 18th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic