Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCF Research Finds Nanoparticles Prevent Cell Damage

Dr. Sudipta Seal in his lab at the University of Central Florida.
Dr. Sudipta Seal in his lab at the University of Central Florida.

Abstract:
University of Central Florida Professor Sudipta Seal and his team have engineered a nanoparticle that appears to prevent cell damage.

UCF Research Finds Nanoparticles Prevent Cell Damage

Orlando, FL | Posted on June 29th, 2009

Seal and his team engineered nanoparticles of cerium oxide (called nanoceria), a material long used in ceramics and fuel cells. In its nanocrystalline form it is non-toxic and appears to work as an antioxidant working to protect cells. Seal's work is recognized by the National Science Foundation this month, which featured him in a Behind the Scenes article at LiveScience.com.

Nanoceria show promise and may protect healthy cells from the damaging effects of radiation given as cancer treatments, and it shows promise for treating arthritis, wound healing, spinal cord injuries and neurodegenerative diseases. In collaboration with researchers at Imperial College London, Seal and his colleagues are also incorporating these nanostructures into bio-scaffolds for tissue engineering.


"It is very exciting," Seal said. "We have found that the nanoceria behave like antioxidants, protecting cells from oxidative stress and they can be fine tuned to potentially deliver medical treatments directly into the cells."

Oxidative stress has been implicated as a cause of arthritis, heart disease and even aging. It also plays a role in several incurable eye diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal degeneration.

Oxidative stress occurs when too many reactive oxygen species (ROS) are present. These powerful molecules are generated by exposure to ionizing radiation and by commonplace reduction-oxidation reactions within cells. (Peroxide and free radicals are two examples of ROS.)

Usually, enzymes known as antioxidants protect cells from oxidative stress by disarming ROS and minimizing their toxic effects. But sometimes, the number of ROS overwhelms a biological system, causing damage to proteins, DNA and other cellular materials.

In the nanocrystalline form Seal and his team engineered, the nanoceria act as powerful antioxidant because its latticework crystal structure can capture oxygen and the material has a large surface area reducing the effects of ROS.

Nanoceria are also able to regenerate their antioxidant abilities, so repeated doses like taking antioxidant vitamins daily, may not be needed, Seal said.

Seal's NSF funded NIRT team includes UCF's Associate Professor William Self, UCF theoretical chemist Asterm Masunov from UCF's Nanoscience and Technology Center, and vision scientist James McGinnis, from the University of Oklahoma Health Sciences Center.

His team's previous work found that nanoceria could also deliver medicine to the retinas of mice with glaucoma.

So far the team has obtained two patents related to the promising nanoceria, and McGinnis has launched a new company to develop medical applications. Meanwhile, Seal and his colleagues continue to investigate the chemical properties of cerium oxide and other rare earth metals and oxides, identifying and investigating various forms with potential applications in medicine and energy. Findings from the ongoing research have been published in several journals including ACS Nano.

Because of its catalytic nature, cerium oxide nanoparticles and their hybrids could also be used efficiently in methanol-ethanol conversion, in the production of hydrogen from sugar cane, for pollution control and as an electrolyte in fuel cells. More research is needed in these areas.


"We have just scratched the surface of what nanoceria can do," he says. "There are endless possibilities."

Along with National Science Foundation award, the National Institutes of Health contributed funding toward this research.

The National Academy of Engineering (NAE) also this month named Seal as one the country's brightest young engineers and will participate in the 15th annual Frontiers of Engineering Symposium in September. He is one of 88 honored and his colleagues include professors and researchers at MIT, Cornell, Microsoft, NASA, Ford Motor Company and John Hopkins.

####

About University of Central Florida
The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 50,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

Contacts:
UCF Professor Seal Sudpita
407-823-5277

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Cool Calculations for Cold Atoms: New theory of universal three-body encounters September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Nanomedicine

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Nanoscale assembly line August 29th, 2014

Announcements

New synthesis method may shape future of nanostructures, clean energy: Findings advance efficient solar spliting of water into hydrogen fuel September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Environment

New Nanosorbent Helps Elimination of Colorants from Textile Wastewater August 25th, 2014

Production of Toxic Ion Nanosorbents with High Sorption Capacity in Iran August 17th, 2014

PerkinElmer to Display Innovative Detection and Informatics Offerings at ACS National Meeting & Exposition Detection, Data Visualization and Analytics for Chemistry Professionals August 8th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Energy

New synthesis method may shape future of nanostructures, clean energy: Findings advance efficient solar spliting of water into hydrogen fuel September 2nd, 2014

Future solar panels September 2nd, 2014

Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices August 28th, 2014

Aspen Aerogels, Inc. to Present at Barclays CEO Energy-Power Conference August 27th, 2014

Fuel Cells

Media Advisory: Minister Rempel to Announce Support for Alberta's Nanotechnology Sector June 20th, 2014

Evolution of a Bimetallic Nanocatalyst June 6th, 2014

University of Surrey collaborates with India and Tata Steel to revolutionise renewable energy March 26th, 2014

Novel membrane reveals water molecules will bounce off a liquid surface: Study may lead to more efficient water-desalination systems, fundamental understanding of fluid flow March 16th, 2014

Nanobiotechnology

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Nanoscale assembly line August 29th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE