Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UCF Research Finds Nanoparticles Prevent Cell Damage

Dr. Sudipta Seal in his lab at the University of Central Florida.
Dr. Sudipta Seal in his lab at the University of Central Florida.

Abstract:
University of Central Florida Professor Sudipta Seal and his team have engineered a nanoparticle that appears to prevent cell damage.

UCF Research Finds Nanoparticles Prevent Cell Damage

Orlando, FL | Posted on June 29th, 2009

Seal and his team engineered nanoparticles of cerium oxide (called nanoceria), a material long used in ceramics and fuel cells. In its nanocrystalline form it is non-toxic and appears to work as an antioxidant working to protect cells. Seal's work is recognized by the National Science Foundation this month, which featured him in a Behind the Scenes article at LiveScience.com.

Nanoceria show promise and may protect healthy cells from the damaging effects of radiation given as cancer treatments, and it shows promise for treating arthritis, wound healing, spinal cord injuries and neurodegenerative diseases. In collaboration with researchers at Imperial College London, Seal and his colleagues are also incorporating these nanostructures into bio-scaffolds for tissue engineering.


"It is very exciting," Seal said. "We have found that the nanoceria behave like antioxidants, protecting cells from oxidative stress and they can be fine tuned to potentially deliver medical treatments directly into the cells."

Oxidative stress has been implicated as a cause of arthritis, heart disease and even aging. It also plays a role in several incurable eye diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal degeneration.

Oxidative stress occurs when too many reactive oxygen species (ROS) are present. These powerful molecules are generated by exposure to ionizing radiation and by commonplace reduction-oxidation reactions within cells. (Peroxide and free radicals are two examples of ROS.)

Usually, enzymes known as antioxidants protect cells from oxidative stress by disarming ROS and minimizing their toxic effects. But sometimes, the number of ROS overwhelms a biological system, causing damage to proteins, DNA and other cellular materials.

In the nanocrystalline form Seal and his team engineered, the nanoceria act as powerful antioxidant because its latticework crystal structure can capture oxygen and the material has a large surface area reducing the effects of ROS.

Nanoceria are also able to regenerate their antioxidant abilities, so repeated doses like taking antioxidant vitamins daily, may not be needed, Seal said.

Seal's NSF funded NIRT team includes UCF's Associate Professor William Self, UCF theoretical chemist Asterm Masunov from UCF's Nanoscience and Technology Center, and vision scientist James McGinnis, from the University of Oklahoma Health Sciences Center.

His team's previous work found that nanoceria could also deliver medicine to the retinas of mice with glaucoma.

So far the team has obtained two patents related to the promising nanoceria, and McGinnis has launched a new company to develop medical applications. Meanwhile, Seal and his colleagues continue to investigate the chemical properties of cerium oxide and other rare earth metals and oxides, identifying and investigating various forms with potential applications in medicine and energy. Findings from the ongoing research have been published in several journals including ACS Nano.

Because of its catalytic nature, cerium oxide nanoparticles and their hybrids could also be used efficiently in methanol-ethanol conversion, in the production of hydrogen from sugar cane, for pollution control and as an electrolyte in fuel cells. More research is needed in these areas.


"We have just scratched the surface of what nanoceria can do," he says. "There are endless possibilities."

Along with National Science Foundation award, the National Institutes of Health contributed funding toward this research.

The National Academy of Engineering (NAE) also this month named Seal as one the country's brightest young engineers and will participate in the 15th annual Frontiers of Engineering Symposium in September. He is one of 88 honored and his colleagues include professors and researchers at MIT, Cornell, Microsoft, NASA, Ford Motor Company and John Hopkins.

####

About University of Central Florida
The University of Central Florida is a metropolitan research university that ranks as the 5th largest in the nation with more than 50,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy.

For more information, please click here

Contacts:
UCF Professor Seal Sudpita
407-823-5277

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Possible Futures

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

Nanomedicine

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

Announcements

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

Environment

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Wood filter removes toxic dye from water April 21st, 2017

Making Batteries From Waste Glass Bottles: UCR researchers are turning glass bottles into high performance lithium-ion batteries for electric vehicles and personal electronics April 19th, 2017

Shedding light on the absorption of light by titanium dioxide April 14th, 2017

Energy

SUNY Polytechnic Institute Announces Total of 172 Teams Selected to Compete in Solar in Your Community Challenge: Teams from 40 states, plus Washington, DC, 2 Territories, and 4 American Indian Reservations, Will Deploy Solar in Underserved Communities April 20th, 2017

Better living through pressure: Functional nanomaterials made easy April 19th, 2017

Shedding light on the absorption of light by titanium dioxide April 14th, 2017

Controlling forces between atoms, molecules, promising for ‘2-D hyperbolic’ materials April 4th, 2017

Fuel Cells

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Scientists boost catalytic activity for key chemical reaction in fuel cells: New platinum-based catalysts with tensile surface strain could improve fuel cell efficiency December 19th, 2016

It's basic: Alternative fuel cell technology reduces cost: Study sets performance targets for metal-free fuel cell membrane December 13th, 2016

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Nanobiotechnology

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project