Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Abstract:
Carbon nanotubes, one of the original engineered nanomaterials, also may prove to be among the most versatile, as numerous teams of investigators continue to develop novel nanotube-based therapeutic and diagnostic tools. Over the past month, three new research papers have highlighted the potential of nanotubes as weapons against cancer.

Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Bethesda, MD | Posted on June 27th, 2009

Reporting its work in the journal Biomacromolecules, a group headed by James R. Baker, Jr., M.D., University of Michigan, describes its success in linking single-molecule nanoparticles known as dendrimers to the surface of multiwalled carbon nanotubes. The resulting combination nanomaterial is highly stable, readily disperses in water, and is biocompatible.

The dendrimers that Dr. Baker's group uses function as targeting agents that deliver the nanotubes specifically to tumor cells that overexpress high-affinity folic acid receptors. Although other research teams also have developed methods for targeting nanotubes to tumors, this approach holds particular promise because dendrimers also can be modified to carry drugs and imaging agents as well as targeting agents. As a result, explained Dr. Baker, who heads one of the 12 National Cancer Institute Cancer Nanotechnology Platform Partnerships, this current research provides a one-step method for adding multiple functions to carbon nanotubes without the need for developing complex new methods for modifying the nanotubes.

Efforts to develop carbon nanotubes for use in cancer applications also received a boost from work presented in a set of two papers published in the Journal of Biomedical Optics. In these papers, a team of investigators led by Alex Biris, Ph.D., and Vladimir P. Zharov, Ph.D., D.Sc., University of Arkansas at Little Rock, describes methods for detecting, tracking, and killing cancer cells in real time with carbon nanotubes.

In their first paper, the investigators demonstrate that they can use a technique known as Raman spectroscopy to track carbon nanotubes as they move through a living animal. "Until now, nobody has been able to fully understand and study in vivo and in real time how these nanoparticles travel through a living system," said Dr. Biris. "By using Raman spectroscopy, we showed that it is possible not only to monitor and detect nanomaterials moving through the circulation, but also to detect single cancer cells tagged with carbon nanotubes. In this way, we can measure their clearance rate and their biodistribution kinetics through the lymph and blood systems."

Dr. Zharov emphasized that in vivo Raman flow cytometry is promising for the detection and identification of a broad spectrum of various nanoparticles with strong Raman scattering properties, such as cells, bacteria, and even viruses. "Before any clinical application of nanoparticles, it is imperative to determine their pharmacological profiles," he said. "This tool will provide this function as a supplement or even as an alternative to the existing methods."

In this project, Drs. Biris and Zharov and colleague Ekaterina I. Galanzha, M.D., injected a single human cancer cell containing carbon nanotube material in the tail vein of a test rat. They were able to follow the circulation of the carbon nanotubes in the blood vessels to the rat's ear, tracking the cell through the rat's bloodstream, lymphatic system, and tissue with a Raman spectrometer.

In their second paper, Drs. Biris and Zharov show that once carbon nanotubes reach tumors and their location is pinpointed using another technique known as time-resolved infrared thermal imaging, the nanotubes can be turned into miniature heaters through laser irradiation. The hot nanotubes then bake the tumors to death from the inside out. This set of experiments demonstrates that the cancer-killing process affects only the nanotube-labeled cancer cells, which disintegrate and die within a matter of hours after treatment. The investigators believe that this approach could be particularly useful for treating small tumors, tumor margins, and micrometastases.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Multifunctional dendrimer-modified multiwalled carbon nanotubes: synthesis, characterization, and in vitro cancer cell targeting and imaging.”

View abstract 1 - “In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues.”

View abstract 2 - “Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.”

Related News Press

News and information

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Beyond the lithium ion -- a significant step toward a better performing battery April 18th, 2015

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Beyond the lithium ion -- a significant step toward a better performing battery April 18th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

Long Island Capital Alliance Announces Participants for Brookhaven National Laboratory Technology Transfer Capital Forum on May 8: Keynote Speaker Dr. Doon Gibbs, Director of Brookhaven National Laboratory April 16th, 2015

Major advance in artificial photosynthesis poses win/win for the environment: Berkeley Lab researchers perform solar-powered green chemistry with captured CO2 April 16th, 2015

Nanotubes/Buckyballs

Nanotubes with two walls have singular qualities: Rice University lab calculates unique electronic qualities of double-walled carbon nanotubes April 16th, 2015

MIT sensor detects spoiled meat: Tiny device could be incorporated into 'smart packaging' to improve food safety April 15th, 2015

Taking aircraft manufacturing out of the oven: New technique uses carbon nanotube film to directly heat and cure composite materials April 14th, 2015

Iranian Scientists Evaluate Dynamic Interaction between 2 Carbon Nanotubes April 14th, 2015

Nanomedicine

Novel nanoparticles could save soldiers' lives after explosions April 15th, 2015

Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors April 14th, 2015

Iranian Scientists Evaluate Dynamic Interaction between 2 Carbon Nanotubes April 14th, 2015

Gold by special delivery intensifies cancer-killing radiation April 13th, 2015

Discoveries

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Major advance in artificial photosynthesis poses win/win for the environment: Berkeley Lab researchers perform solar-powered green chemistry with captured CO2 April 16th, 2015

Newly-Developed Nanocatalysts Increase Performance of Fuel Cells April 16th, 2015

Lanthanide-Organic Framework Nanothermometers Prepared by Spray-Drying April 16th, 2015

Announcements

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Beyond the lithium ion -- a significant step toward a better performing battery April 18th, 2015

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE