Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Abstract:
Carbon nanotubes, one of the original engineered nanomaterials, also may prove to be among the most versatile, as numerous teams of investigators continue to develop novel nanotube-based therapeutic and diagnostic tools. Over the past month, three new research papers have highlighted the potential of nanotubes as weapons against cancer.

Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Bethesda, MD | Posted on June 27th, 2009

Reporting its work in the journal Biomacromolecules, a group headed by James R. Baker, Jr., M.D., University of Michigan, describes its success in linking single-molecule nanoparticles known as dendrimers to the surface of multiwalled carbon nanotubes. The resulting combination nanomaterial is highly stable, readily disperses in water, and is biocompatible.

The dendrimers that Dr. Baker's group uses function as targeting agents that deliver the nanotubes specifically to tumor cells that overexpress high-affinity folic acid receptors. Although other research teams also have developed methods for targeting nanotubes to tumors, this approach holds particular promise because dendrimers also can be modified to carry drugs and imaging agents as well as targeting agents. As a result, explained Dr. Baker, who heads one of the 12 National Cancer Institute Cancer Nanotechnology Platform Partnerships, this current research provides a one-step method for adding multiple functions to carbon nanotubes without the need for developing complex new methods for modifying the nanotubes.

Efforts to develop carbon nanotubes for use in cancer applications also received a boost from work presented in a set of two papers published in the Journal of Biomedical Optics. In these papers, a team of investigators led by Alex Biris, Ph.D., and Vladimir P. Zharov, Ph.D., D.Sc., University of Arkansas at Little Rock, describes methods for detecting, tracking, and killing cancer cells in real time with carbon nanotubes.

In their first paper, the investigators demonstrate that they can use a technique known as Raman spectroscopy to track carbon nanotubes as they move through a living animal. "Until now, nobody has been able to fully understand and study in vivo and in real time how these nanoparticles travel through a living system," said Dr. Biris. "By using Raman spectroscopy, we showed that it is possible not only to monitor and detect nanomaterials moving through the circulation, but also to detect single cancer cells tagged with carbon nanotubes. In this way, we can measure their clearance rate and their biodistribution kinetics through the lymph and blood systems."

Dr. Zharov emphasized that in vivo Raman flow cytometry is promising for the detection and identification of a broad spectrum of various nanoparticles with strong Raman scattering properties, such as cells, bacteria, and even viruses. "Before any clinical application of nanoparticles, it is imperative to determine their pharmacological profiles," he said. "This tool will provide this function as a supplement or even as an alternative to the existing methods."

In this project, Drs. Biris and Zharov and colleague Ekaterina I. Galanzha, M.D., injected a single human cancer cell containing carbon nanotube material in the tail vein of a test rat. They were able to follow the circulation of the carbon nanotubes in the blood vessels to the rat's ear, tracking the cell through the rat's bloodstream, lymphatic system, and tissue with a Raman spectrometer.

In their second paper, Drs. Biris and Zharov show that once carbon nanotubes reach tumors and their location is pinpointed using another technique known as time-resolved infrared thermal imaging, the nanotubes can be turned into miniature heaters through laser irradiation. The hot nanotubes then bake the tumors to death from the inside out. This set of experiments demonstrates that the cancer-killing process affects only the nanotube-labeled cancer cells, which disintegrate and die within a matter of hours after treatment. The investigators believe that this approach could be particularly useful for treating small tumors, tumor margins, and micrometastases.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Multifunctional dendrimer-modified multiwalled carbon nanotubes: synthesis, characterization, and in vitro cancer cell targeting and imaging.”

View abstract 1 - “In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues.”

View abstract 2 - “Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.”

Related News Press

News and information

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Govt.-Legislation/Regulation/Funding/Policy

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

Nanotubes/Buckyballs/Fullerenes/Nanorods

Carbon is the new black: Researchers use carbon nanotubes to develop clothing that can double as batteries July 10th, 2018

Nano-saturn: Supramolecular complex formation: Anthracene macrocycle and C60 fullerene June 8th, 2018

Unzipping graphene nanotubes into nanoribbons: New study shows elegant mathematical solution to understand how the flow of electrons changes when carbon nanotubes turn into zigzag nanoribbons June 6th, 2018

Making carbon nanotubes as usable as common plastics: Researchers discover that cresols disperse carbon nanotubes at unprecedentedly high concentrations May 15th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Discoveries

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Announcements

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project