Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoscale Holes Provide Speed Boost for Diagnostic Tests

Abstract:
Microfluidic devices, essentially miniaturized chemical laboratories etched into material similar to a microprocessor chip, are revolutionizing diagnostic medicine by providing a technology platform that is more sensitive and less expensive than conventional analytical technologies. A new sensing method that relies on nanoscale holes drilled into a microfluidic device also could add "faster" to the list of benefits afforded by microfluidics.

Nanoscale Holes Provide Speed Boost for Diagnostic Tests

Bethesda, MD | Posted on June 27th, 2009

Reporting their work in the journal Analytical Chemistry, researchers at the University of British Columbia created a grid of 30 x 30 flow-through nanoscale holes to create a highly responsive sensor system that can detect biomolecules of interest without requiring the additional use of an optical label. They used a tightly focused laser to drill holes through a 100-nanometer-thick layer of gold deposited on a 100-nanometer-thick slab of silicon nitride. The resulting sensor array then was integrated into a microfluidic chip made of poly(dimethylsiloxane), a standard material used to make lab-on-a-chip devices for biomedical applications.

With the array in hand, the investigators then attached a monoclonal antibody to the gold lining inside the holes. This monoclonal antibody binds to a cancer biomarker protein known as PAX8. The researchers then took advantage of an optical phenomenon known as surface plasmon resonance (SPR), which takes place on thin films of gold. When irradiated with laser light, thin gold films will emit a sharp, bright burst of light whose wavelength changes as various molecules stick to the gold surface. In this case, the SPR signal changed whenever PAX8 bound to the antibody attached to the gold film lining the array holes. When compared with established SPR-based measurement techniques, the flow-through device had a response time that was sixfold faster while measuring PAX8 present at concentrations in the attomolar range.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Nanoholes as nanochannels: flow-through plasmonic sensing.”

Related News Press

News and information

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

Microfluidics/Nanofluidics

Researchers invent 'smart' thread that collects diagnostic data when sutured into tissue: Advances could pave way for new generation of implantable and wearable diagnostics July 18th, 2016

Droplets finally all the same size -- in a nanodroplet library June 20th, 2016

NanoLabNL boosts quality of research facilities as Dutch Toekomstfonds invests firmly June 10th, 2016

Little ANTs: Researchers build the world's tiniest engine May 3rd, 2016

Govt.-Legislation/Regulation/Funding/Policy

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New reaction for the synthesis of nanostructures July 21st, 2016

Weird quantum effects stretch across hundreds of miles July 21st, 2016

Scientists glimpse inner workings of atomically thin transistors July 21st, 2016

Nanomedicine

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Sensors

Electron 'spin control' of levitated nanodiamonds could bring advances in sensors, quantum information processing July 20th, 2016

Easier, faster, cheaper: A full-filling approach to making nanotubes of consistent quality: Approach opens a straightforward route for engineering the properties of single-wall carbon nanotubes July 19th, 2016

Researchers invent 'smart' thread that collects diagnostic data when sutured into tissue: Advances could pave way for new generation of implantable and wearable diagnostics July 18th, 2016

UNIST engineers octopus-inspired smart adhesive pads July 15th, 2016

Discoveries

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

Announcements

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic