Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoscale Holes Provide Speed Boost for Diagnostic Tests

Abstract:
Microfluidic devices, essentially miniaturized chemical laboratories etched into material similar to a microprocessor chip, are revolutionizing diagnostic medicine by providing a technology platform that is more sensitive and less expensive than conventional analytical technologies. A new sensing method that relies on nanoscale holes drilled into a microfluidic device also could add "faster" to the list of benefits afforded by microfluidics.

Nanoscale Holes Provide Speed Boost for Diagnostic Tests

Bethesda, MD | Posted on June 27th, 2009

Reporting their work in the journal Analytical Chemistry, researchers at the University of British Columbia created a grid of 30 x 30 flow-through nanoscale holes to create a highly responsive sensor system that can detect biomolecules of interest without requiring the additional use of an optical label. They used a tightly focused laser to drill holes through a 100-nanometer-thick layer of gold deposited on a 100-nanometer-thick slab of silicon nitride. The resulting sensor array then was integrated into a microfluidic chip made of poly(dimethylsiloxane), a standard material used to make lab-on-a-chip devices for biomedical applications.

With the array in hand, the investigators then attached a monoclonal antibody to the gold lining inside the holes. This monoclonal antibody binds to a cancer biomarker protein known as PAX8. The researchers then took advantage of an optical phenomenon known as surface plasmon resonance (SPR), which takes place on thin films of gold. When irradiated with laser light, thin gold films will emit a sharp, bright burst of light whose wavelength changes as various molecules stick to the gold surface. In this case, the SPR signal changed whenever PAX8 bound to the antibody attached to the gold film lining the array holes. When compared with established SPR-based measurement techniques, the flow-through device had a response time that was sixfold faster while measuring PAX8 present at concentrations in the attomolar range.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Nanoholes as nanochannels: flow-through plasmonic sensing.”

Related News Press

News and information

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

Controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015

Production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran May 27th, 2015

Microfluidics/Nanofluidics

What makes cancer cells spread? New device offers clues May 19th, 2015

Microchip captures clusters of circulating tumor cells -- NIH study May 18th, 2015

Light in a spin: Researchers demonstrate angular accelerating light April 15th, 2015

Device extracts rare tumor cells using sound: Microfluidic chip developed by CMU President Suresh and collaborators uses acoustic waves to separate circulating tumor cells from blood cells April 7th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Nanomedicine

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Nanostructures Increase Corrosion Resistance in Metallic Body Implants May 24th, 2015

Sensors

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Record high sensitive Graphene Hall sensors May 21st, 2015

Graphene enables tunable microwave antenna May 15th, 2015

Janusz Bryzek Joins MEMS Industry Group to Lead New TSensors Division - New Division will Focus on Accelerating Development of Emerging Ultra-high Volume Sensors Supporting Abundance, mHealth and IoT May 14th, 2015

Discoveries

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

Production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran May 27th, 2015

Fine-tuned molecular orientation is key to more efficient solar cells May 26th, 2015

Announcements

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

Controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015

Production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran May 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project