Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Computer-Guided Nanoparticle Therapy Destroys Tumors

Abstract:
Gold nanoshells are among the most promising new nanoscale therapeutics being developed to kill tumors, acting as antennas that turn light energy into heat that cooks cancer to death. Now, a multi-institutional research team has shown that polymer-coated gold nanorods one-up their spherical counterparts, with a single dose completely destroying all tumors in a nonhuman animal model of human cancer.

Computer-Guided Nanoparticle Therapy Destroys Tumors

Bethesda, MD | Posted on June 27th, 2009

Reporting its work in the journal Cancer Research, a research team headed by Sangeeta N. Bhatia, M.D., Ph.D., Massachusetts Institute of Technology, and Michael J. Sailor, Ph.D., University of California, San Diego, described its development of gold nanorods, coated with polyethylene glycol, which set a new record for the time they remain circulating in the bloodstream. This long-circulation half-life of approximately 17 hours affords the nanorods the opportunity to accumulate in tumors, thanks to the leaky blood vessels that surround malignancies. Both Dr. Bhatia and Dr. Sailor are members of the National Cancer Institute's Alliance for Nanotechnology in Cancer.

Gold nanoparticles can absorb different frequencies of light, depending on their shape. The rod-shaped particles developed for this study absorb near-infrared light, which heats the nanorods but passes harmlessly through human tissue. In the current work, tumors in mice that received an intravenous injection of nanorods plus near-infrared laser treatment disappeared within 15 days. Those mice survived for 3 months, with no evidence of recurrence, until the end of the study, whereas mice that received no treatment or only the nanorods or laser died within weeks.

During a single exposure to a near-infrared laser, the nanorods heat up to 70° C, hot enough to kill tumor cells. Additionally, heating them to a lower temperature weakens tumor cells enough to enhance the effectiveness of existing chemotherapy treatments, raising the possibility of using the nanorods as a supplement to those treatments. The nanorods also could be used to kill tumor cells left behind after surgery. The investigators note that the nanorods can be more than 1,000 times more precise than a surgeon's scalpel, so potentially they could remove residual cells the surgeon cannot get at.

Another useful characteristic of the gold nanorods is that they are very efficient at absorbing x-rays, providing a sensitivity boost to x-ray imaging methods such as computerized tomography scanning. The investigators took advantage of this property, using x-rays to create a detailed three-dimensional map of where the nanorods accumulated in the tumor-bearing animals. They then used this map to calculate the optimal irradiation protocol to maximize the tumor-killing effect and minimize damage to healthy tissue.

The nanorods' homing abilities also make them a promising tool for diagnosing tumors. After the particles are injected, they can be imaged using a technique known as Raman scattering. Any tissue that lights up, other than liver or spleen tissue, could harbor an invasive tumor. In a second paper, published in the journal Advanced Materials, the researchers showed they could enhance the nanorods' imaging abilities by adding molecules that absorb near-infrared light to the surface of the nanorods. Because of this surface-enhanced Raman scattering, very low concentrations of nanorods—only a few parts per trillion in water—can be detected.

Another advantage of the nanorods is that by coating them with different types of light-scattering molecules, they can be designed to simultaneously gather multiple types of information—not only whether there is a tumor but also whether there is a risk of it invading other tissues, whether it is a primary or secondary tumor, and where it originated.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.”

View journal citation - “SERS-coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating.”

Related News Press

News and information

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Nanomedicine

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Nanoscale assembly line August 29th, 2014

Copper shines as flexible conductor August 29th, 2014

Discoveries

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Announcements

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Research partnerships

Leading European communications companies and research organizations have launched an EU project developing the future 5th Generation cellular mobile networks August 28th, 2014

New technique uses fraction of measurements to efficiently find quantum wave functions August 28th, 2014

The thunder god vine, assisted by nanotechnology, could shake up future cancer treatment: Targeted therapy for hepatocellular carcinoma using nanotechnology August 27th, 2014

Competition for Graphene: Berkeley Lab Researchers Demonstrate Ultrafast Charge Transfer in New Family of 2D Semiconductors August 26th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE