Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Abstract:
Below is the first part of a two-part series summarizing the talks presented at the 3rd Annual NanoBio Symposium hosted by the Johns Hopkins Institute for NanoBioTechnology, on May 18, 2009. Five talks from the eight speakers who presented that day are described below.

INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Baltimore, Md | Posted on June 24th, 2009

Novel Approaches to Understand Neurodegenerative and Neuropsychiatric Diseases

Ted Dawson - Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases, Department of Neurology; Institute for Cell Engineering, Johns Hopkins School of Medicine

Inducible pluripotent stem cells (iPS) derived from patients with Parkinson's disease, schizophrenia, autism spectrum disorders, Down syndrome and other neurodegenerative or neuropsychiatric conditions could become better tools to study disease processes than mouse models, which lack certain genetic markers found in humans. By transplanting human-derived iPS cells that exhibit neurological conditions into animals, scientists could create human disease-specific models that will serve as the drug screening platform for the future. The Institute for Cell Engineering works with scientists from INBT to use nanofibers, quantum dots and other methods to control and direct differentiation of iPS cells into neurological cells, such as astrocytes, oligodendrocytes and neurons. (by Mary Spiro)

Developing Contrast Agents for Imaging Drug Delivery

Michael McMahon - Assistant Professor, Radiology/MR Division; FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Johns Hopkins School of Medicine

Contrast agents are often used in conjunction with medical imaging to enhance images. Michael McMahon explained how he and his colleagues are developing magnetic resonance contrast agents based on the imaging technique Chemical Exchange Saturation Transfer (CEST) that exhibit distinct colors similar to fluorescent agents. They recently incorporated these contrast agents into liposomes, which are vehicles for drug delivery. They injected the liposomes into mice and detected the contrast agent at various times post-injection. Due to their distinct colors, CEST-based contrast agents could prove useful for imaging drug delivery and release in humans. (by Adam Book)

Using Nanotechnology to Guide Blood Vessel Formation

Sharon Gerecht - Assistant Professor, Department Chemical and Biomolecular Engineering; Institute for NanoBioTechnology; Whiting School of Engineering, Johns Hopkins University

Stem cells can become a wide variety of specialized cell types. One type of stem cell, the endothelial progenitor cell (EPC), grows into cells that form blood vessels. Sharon Gerecht described how she is developing surfaces that guide EPCs into forming blood vessels. They grew EPCs on either flat or nanotopographic surfaces. Cells on the flat surface grew randomly, while cells on the nanotopographic surface aligned with the nanoscale etchings. Gerecht is currently determining the best way to persuade the cells to form the proper three-dimensional organization of living blood vessel networks. (by Adam Book)

Directing Stem Cell Fate with Nanofiber Matrices

Hai-Quan Mao - Assistant Professor, Department of Materials Science and Engineering, Whitaker Biomedical Engineering Institute; Whiting School of Engineering, Johns Hopkins University

The use of stem cells to replace diseased tissues in the body is a promising avenue of research. However, this therapy depends on the stem cells surviving and growing into the correct type of cell after being placed in the body. Hai-Quan Mao talked about a technique for growing neural stem cells on nanofiber matrices, which can be manipulated to form the various environments found in the human body. By altering the nanotopography of the matrix and adding chemical cues, they can coax a neural stem cell to differentiate into a desired cell type. (by Adam Book)

Future Applications of Nanotechnology for the Treatment of Brain Tumors

Alessandro Olivi - Professor, Neurosurgery and Oncology; Chair, Department of Neurosurgery, Johns Hopkins Bayview Medical Center

Recent neurosurgical advances in imaging, preoperative planning, microsurgical techniques, and intra-operative and post-operative patient care are improving the treatment of brain tumors. Better imaging allows more precise targeting of the affected area and the determination of the optimal trajectory for procedures that are minimally invasive and more respectful of function. The use of nanoparticles for drug delivery, targeted nanoparticle immunotherapy, thermotherapy, photodynamic therapy, intracellular delivery, and the use of nanoparticles to increase MRI image delineation of brain tumors holds much promise with increased survival time. Targeted immunotherapy includes intercellular delivery and delivery via incapsulation and coating. Targeted drug delivery of chemotherapy agents over a three to four week period at the level of the tumor bed is now possible via the Gliadel Wafer. The use of nanotechnology will likely bring us to the next level in the treatment of malignant brain tumors. (by Gina Hagler)

*Gina Hagler is a is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.

**Adam Book is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.


####

About Johns Hopkins Institute for NanoBioTechnology
The Johns Hopkins Institute for NanoBioTechnology (INBT) at Johns Hopkins University brings together more than 175 researchers from the Bloomberg School of Public Health, Krieger School of Arts and Sciences, School of Medicine, Applied Physics Laboratory, and Whiting School of Engineering to create new knowledge and new technologies at the interface of nanoscience and medicine.

For more information, please click here

Contacts:
Johns Hopkins Institute for NanoBioTechnology
3400 North Charles Street
Baltimore, MD 21218


Phone: (410) 516-3423
Fax: (410) 516-2355

Copyright © Johns Hopkins Institute for NanoBioTechnology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Sustainable Nanotechnologies Project November 20th, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Possible Futures

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Open Materials Development Will Be Key for HP's Success in 3D Printing: HP can make a big splash in 3D printing, but it needs to shore up technology claims and avoid the temptation of the razor/razor blade business model in order to flourish November 11th, 2014

Nanomedicine

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Announcements

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Events/Classes

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

Sustainable Nanotechnologies Project November 20th, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Nanometrics Announces Upcoming Investor Events November 19th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE