Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Abstract:
Below is the first part of a two-part series summarizing the talks presented at the 3rd Annual NanoBio Symposium hosted by the Johns Hopkins Institute for NanoBioTechnology, on May 18, 2009. Five talks from the eight speakers who presented that day are described below.

INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Baltimore, Md | Posted on June 24th, 2009

Novel Approaches to Understand Neurodegenerative and Neuropsychiatric Diseases

Ted Dawson - Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases, Department of Neurology; Institute for Cell Engineering, Johns Hopkins School of Medicine

Inducible pluripotent stem cells (iPS) derived from patients with Parkinson's disease, schizophrenia, autism spectrum disorders, Down syndrome and other neurodegenerative or neuropsychiatric conditions could become better tools to study disease processes than mouse models, which lack certain genetic markers found in humans. By transplanting human-derived iPS cells that exhibit neurological conditions into animals, scientists could create human disease-specific models that will serve as the drug screening platform for the future. The Institute for Cell Engineering works with scientists from INBT to use nanofibers, quantum dots and other methods to control and direct differentiation of iPS cells into neurological cells, such as astrocytes, oligodendrocytes and neurons. (by Mary Spiro)

Developing Contrast Agents for Imaging Drug Delivery

Michael McMahon - Assistant Professor, Radiology/MR Division; FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Johns Hopkins School of Medicine

Contrast agents are often used in conjunction with medical imaging to enhance images. Michael McMahon explained how he and his colleagues are developing magnetic resonance contrast agents based on the imaging technique Chemical Exchange Saturation Transfer (CEST) that exhibit distinct colors similar to fluorescent agents. They recently incorporated these contrast agents into liposomes, which are vehicles for drug delivery. They injected the liposomes into mice and detected the contrast agent at various times post-injection. Due to their distinct colors, CEST-based contrast agents could prove useful for imaging drug delivery and release in humans. (by Adam Book)

Using Nanotechnology to Guide Blood Vessel Formation

Sharon Gerecht - Assistant Professor, Department Chemical and Biomolecular Engineering; Institute for NanoBioTechnology; Whiting School of Engineering, Johns Hopkins University

Stem cells can become a wide variety of specialized cell types. One type of stem cell, the endothelial progenitor cell (EPC), grows into cells that form blood vessels. Sharon Gerecht described how she is developing surfaces that guide EPCs into forming blood vessels. They grew EPCs on either flat or nanotopographic surfaces. Cells on the flat surface grew randomly, while cells on the nanotopographic surface aligned with the nanoscale etchings. Gerecht is currently determining the best way to persuade the cells to form the proper three-dimensional organization of living blood vessel networks. (by Adam Book)

Directing Stem Cell Fate with Nanofiber Matrices

Hai-Quan Mao - Assistant Professor, Department of Materials Science and Engineering, Whitaker Biomedical Engineering Institute; Whiting School of Engineering, Johns Hopkins University

The use of stem cells to replace diseased tissues in the body is a promising avenue of research. However, this therapy depends on the stem cells surviving and growing into the correct type of cell after being placed in the body. Hai-Quan Mao talked about a technique for growing neural stem cells on nanofiber matrices, which can be manipulated to form the various environments found in the human body. By altering the nanotopography of the matrix and adding chemical cues, they can coax a neural stem cell to differentiate into a desired cell type. (by Adam Book)

Future Applications of Nanotechnology for the Treatment of Brain Tumors

Alessandro Olivi - Professor, Neurosurgery and Oncology; Chair, Department of Neurosurgery, Johns Hopkins Bayview Medical Center

Recent neurosurgical advances in imaging, preoperative planning, microsurgical techniques, and intra-operative and post-operative patient care are improving the treatment of brain tumors. Better imaging allows more precise targeting of the affected area and the determination of the optimal trajectory for procedures that are minimally invasive and more respectful of function. The use of nanoparticles for drug delivery, targeted nanoparticle immunotherapy, thermotherapy, photodynamic therapy, intracellular delivery, and the use of nanoparticles to increase MRI image delineation of brain tumors holds much promise with increased survival time. Targeted immunotherapy includes intercellular delivery and delivery via incapsulation and coating. Targeted drug delivery of chemotherapy agents over a three to four week period at the level of the tumor bed is now possible via the Gliadel Wafer. The use of nanotechnology will likely bring us to the next level in the treatment of malignant brain tumors. (by Gina Hagler)

*Gina Hagler is a is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.

**Adam Book is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.


####

About Johns Hopkins Institute for NanoBioTechnology
The Johns Hopkins Institute for NanoBioTechnology (INBT) at Johns Hopkins University brings together more than 175 researchers from the Bloomberg School of Public Health, Krieger School of Arts and Sciences, School of Medicine, Applied Physics Laboratory, and Whiting School of Engineering to create new knowledge and new technologies at the interface of nanoscience and medicine.

For more information, please click here

Contacts:
Johns Hopkins Institute for NanoBioTechnology
3400 North Charles Street
Baltimore, MD 21218


Phone: (410) 516-3423
Fax: (410) 516-2355

Copyright © Johns Hopkins Institute for NanoBioTechnology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Superconductor could be realized in a broken Lorenz invariant theory July 7th, 2015

New technique enables magnetic patterns to be mapped in 3-D July 7th, 2015

Crystal structure and magnetism -- new insight into the fundamentals of solid state physics: HZB team decodes relationship between magnetic interactions and the distortions in crystal structure within a geometrically 'frustrated' spinel system July 7th, 2015

Down to the quantum dot: Jülich researchers develop ultrahigh-resolution 3-D microscopy technique for electric fields July 7th, 2015

Possible Futures

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Nanomedicine

Sensor technology can improve accuracy of prostate cancer diagnosis, research shows July 7th, 2015

New technique enables magnetic patterns to be mapped in 3-D July 7th, 2015

Miniature Technology, Large-Scale Impact: Winner of the 2015 Lindros Award for translational medicine, Kjeld Janssen is pushing the boundaries of the emerging lab-on-a-chip technology - See more at: http://www.news.ucsb.edu/2015/015744/miniature-technology-large-scale-impact#stha July 7th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

Announcements

Superconductor could be realized in a broken Lorenz invariant theory July 7th, 2015

New technique enables magnetic patterns to be mapped in 3-D July 7th, 2015

Crystal structure and magnetism -- new insight into the fundamentals of solid state physics: HZB team decodes relationship between magnetic interactions and the distortions in crystal structure within a geometrically 'frustrated' spinel system July 7th, 2015

Down to the quantum dot: Jülich researchers develop ultrahigh-resolution 3-D microscopy technique for electric fields July 7th, 2015

Events/Classes

Expert presentations and practical demonstrations impress nanoparticle characterization seminar attendees July 7th, 2015

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Nanometrics to Announce Second Quarter Financial Results on July 23, 2015 July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Nanobiotechnology

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project