Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Abstract:
Below is the first part of a two-part series summarizing the talks presented at the 3rd Annual NanoBio Symposium hosted by the Johns Hopkins Institute for NanoBioTechnology, on May 18, 2009. Five talks from the eight speakers who presented that day are described below.

INBT Speakers Highlight Nanobio Trends in Neuroscience, Stem Cell Growth, Drug Delivery, Imaging

Baltimore, Md | Posted on June 24th, 2009

Novel Approaches to Understand Neurodegenerative and Neuropsychiatric Diseases

Ted Dawson - Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases, Department of Neurology; Institute for Cell Engineering, Johns Hopkins School of Medicine

Inducible pluripotent stem cells (iPS) derived from patients with Parkinson's disease, schizophrenia, autism spectrum disorders, Down syndrome and other neurodegenerative or neuropsychiatric conditions could become better tools to study disease processes than mouse models, which lack certain genetic markers found in humans. By transplanting human-derived iPS cells that exhibit neurological conditions into animals, scientists could create human disease-specific models that will serve as the drug screening platform for the future. The Institute for Cell Engineering works with scientists from INBT to use nanofibers, quantum dots and other methods to control and direct differentiation of iPS cells into neurological cells, such as astrocytes, oligodendrocytes and neurons. (by Mary Spiro)

Developing Contrast Agents for Imaging Drug Delivery

Michael McMahon - Assistant Professor, Radiology/MR Division; FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Johns Hopkins School of Medicine

Contrast agents are often used in conjunction with medical imaging to enhance images. Michael McMahon explained how he and his colleagues are developing magnetic resonance contrast agents based on the imaging technique Chemical Exchange Saturation Transfer (CEST) that exhibit distinct colors similar to fluorescent agents. They recently incorporated these contrast agents into liposomes, which are vehicles for drug delivery. They injected the liposomes into mice and detected the contrast agent at various times post-injection. Due to their distinct colors, CEST-based contrast agents could prove useful for imaging drug delivery and release in humans. (by Adam Book)

Using Nanotechnology to Guide Blood Vessel Formation

Sharon Gerecht - Assistant Professor, Department Chemical and Biomolecular Engineering; Institute for NanoBioTechnology; Whiting School of Engineering, Johns Hopkins University

Stem cells can become a wide variety of specialized cell types. One type of stem cell, the endothelial progenitor cell (EPC), grows into cells that form blood vessels. Sharon Gerecht described how she is developing surfaces that guide EPCs into forming blood vessels. They grew EPCs on either flat or nanotopographic surfaces. Cells on the flat surface grew randomly, while cells on the nanotopographic surface aligned with the nanoscale etchings. Gerecht is currently determining the best way to persuade the cells to form the proper three-dimensional organization of living blood vessel networks. (by Adam Book)

Directing Stem Cell Fate with Nanofiber Matrices

Hai-Quan Mao - Assistant Professor, Department of Materials Science and Engineering, Whitaker Biomedical Engineering Institute; Whiting School of Engineering, Johns Hopkins University

The use of stem cells to replace diseased tissues in the body is a promising avenue of research. However, this therapy depends on the stem cells surviving and growing into the correct type of cell after being placed in the body. Hai-Quan Mao talked about a technique for growing neural stem cells on nanofiber matrices, which can be manipulated to form the various environments found in the human body. By altering the nanotopography of the matrix and adding chemical cues, they can coax a neural stem cell to differentiate into a desired cell type. (by Adam Book)

Future Applications of Nanotechnology for the Treatment of Brain Tumors

Alessandro Olivi - Professor, Neurosurgery and Oncology; Chair, Department of Neurosurgery, Johns Hopkins Bayview Medical Center

Recent neurosurgical advances in imaging, preoperative planning, microsurgical techniques, and intra-operative and post-operative patient care are improving the treatment of brain tumors. Better imaging allows more precise targeting of the affected area and the determination of the optimal trajectory for procedures that are minimally invasive and more respectful of function. The use of nanoparticles for drug delivery, targeted nanoparticle immunotherapy, thermotherapy, photodynamic therapy, intracellular delivery, and the use of nanoparticles to increase MRI image delineation of brain tumors holds much promise with increased survival time. Targeted immunotherapy includes intercellular delivery and delivery via incapsulation and coating. Targeted drug delivery of chemotherapy agents over a three to four week period at the level of the tumor bed is now possible via the Gliadel Wafer. The use of nanotechnology will likely bring us to the next level in the treatment of malignant brain tumors. (by Gina Hagler)

*Gina Hagler is a is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.

**Adam Book is a master's degree candidate in the Science and Medical Writing through the Krieger School of Arts and Sciences, Advanced Academic Programs.


####

About Johns Hopkins Institute for NanoBioTechnology
The Johns Hopkins Institute for NanoBioTechnology (INBT) at Johns Hopkins University brings together more than 175 researchers from the Bloomberg School of Public Health, Krieger School of Arts and Sciences, School of Medicine, Applied Physics Laboratory, and Whiting School of Engineering to create new knowledge and new technologies at the interface of nanoscience and medicine.

For more information, please click here

Contacts:
Johns Hopkins Institute for NanoBioTechnology
3400 North Charles Street
Baltimore, MD 21218


Phone: (410) 516-3423
Fax: (410) 516-2355

Copyright © Johns Hopkins Institute for NanoBioTechnology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Industrial Nanotech, Inc. to Publish PCAOB Audited Financials July 31st, 2014

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Pressure probing potential photoelectronic manufacturing compound July 31st, 2014

Possible Futures

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

Nanomedicine

Arrowhead to Report Fiscal 2014 Third Quarter Financial Results- Conference Call Scheduled for Tuesday, August 12, 2014 - July 31st, 2014

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Announcements

Industrial Nanotech, Inc. to Publish PCAOB Audited Financials July 31st, 2014

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Pressure probing potential photoelectronic manufacturing compound July 31st, 2014

Events/Classes

Arrowhead to Report Fiscal 2014 Third Quarter Financial Results- Conference Call Scheduled for Tuesday, August 12, 2014 - July 31st, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

WITec to host the 11th Confocal Raman Imaging Symposium from September 29th - October 1st in Ulm, Germany July 28th, 2014

Nanobiotechnology

Harris & Harris Group Invests in Unique NYC Biotech Accelerator July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE