Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanosensor Arrays "Smell" Cancer

Abstract:
In 2006 researchers established that dogs could detect cancer by sniffing the exhaled breath of cancer patients. Now, using nanoscale arrays of detectors, two groups of investigators have shown that a compact mechanical device also can sniff out lung cancer in humans.

Nanosensor Arrays "Smell" Cancer

Bethesda, MD | Posted on April 27th, 2009

Hossam Haick, Ph.D., and his colleagues at the Israel Institute of Technology in Haifa, used a network of 10 sets of chemically modified carbon nanotubes to create a multicomponent sensor capable of discriminating between a healthy breath and one characteristic of lung cancer patients. This work appears in the journal Nano News. Meanwhile, Silvano Dragonieri, M.D., University of Bari, Italy, and his colleagues used a commercial nanoarray-based electronic "nose" to discriminate between the breath of patients with non-small cell lung cancer and chronic obstructive pulmonary disease (COPD). These results appear in the journal Lung Cancer.

The key development in Dr. Haick's team's work demonstrated that the electrical resistance of carbon nanotubes coated with nonpolymeric organic layers changes substantially when nonpolar organic molecules, such as those present in a breath, pass over the nanotubes. Uncoated nanotubes do not respond strongly to the type of nonpolar molecules found in the human breath.

Using 10 different organic coatings, the investigators created field-effect transistors comprising random networks of each of the different coated nanotubes, and the resulting array produces a characteristic change in electrical output when exposed to volatile nonpolar organic substances. A computational technique known as principal component analysis can decipher the complex signal change produced when mixtures of nonpolar organic molecules pass over the sensor network. When plotted in two dimensions, the data from a simulated set of "healthy" and "lung cancer" patients form two clear clusters that readily distinguish the two sets of patients. The investigators also showed that their device could identify healthy rats from those with chronic kidney failure.

Rather than designing their own device, Dr. Dragonieri's group used a Cyranose 320 built by Smiths Detection based in Pasadena, California. This hand-held electronic nose, which is used widely throughout the chemical and food processing industries, employs a nanocomposite sensor array to rapidly detect volatile organic compounds in the air.

In this study, Dr. Dragonieri's team collected breath samples from 10 patients with NSCLC, 10 with COPD, and 10 healthy controls. After drying the samples, the investigators analyzed them using the Cyranose 320 and its onboard statistical software. Smellprints, analogous to fingerprints, from the three groups of patients were clearly distinguishable, with no ambiguity among the three groups. The investigators note that these results warrant conducting a large-scale, prospective clinical trial to determine whether this system could be useful in real clinical settings, including physician offices.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda, MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

“Detection of nonpolar molecules by means of carrier scattering in random networks of carbon nanotubes: Toward diagnosis of diseases via breath samples.”

“An electronic nose in the discrimination of patients with non-small cell cancer and COPD.”

Related News Press

News and information

Measuring the Smallest Magnets July 28th, 2014

WITec to host the 11th Confocal Raman Imaging Symposium from September 29th - October 1st in Ulm, Germany July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Production of Toxic Gas Sensor Based on Nanorods July 28th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

Stanford team achieves 'holy grail' of battery design: A stable lithium anode - Engineers use carbon nanospheres to protect lithium from the reactive and expansive problems that have restricted its use as an anode July 27th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

Nanomedicine

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

Announcements

Measuring the Smallest Magnets July 28th, 2014

WITec to host the 11th Confocal Raman Imaging Symposium from September 29th - October 1st in Ulm, Germany July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Production of Toxic Gas Sensor Based on Nanorods July 28th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE