Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > World’s First Nanofluidic Device with Complex 3-D Surfaces Built

(A) Schematic of the NIST-Cornell nanofluidic device with complex 3-D surfaces. Each “step” of the “staircase” seen on the side marks a different depth within the chamber. The letter “E” shows the direction of the electric field used to move the nanoparticles through the device. The green balls are spheres with diameters of 100 nanometers whose size restricts them from moving into the shallower regions of the chamber. The coil in the deep end of the chamber (upper right corner) is a single DNA strand that elongates (upper left corner) in the shallow end.
(B) Photomicrograph showing fluorescently tagged spherical nanoparticles stopped at the 100-nanometer level of the chamber, the depth that corresponds to their diameter.
(C) Photomicrograph of a single DNA strand that is coiled in the deep end of chamber (box at far right) and elongated in the shallow end (box at far left). Larger boxes are closeups showing the fluorescently tagged strands.

Credit: NIST
(A) Schematic of the NIST-Cornell nanofluidic device with complex 3-D surfaces. Each “step” of the “staircase” seen on the side marks a different depth within the chamber. The letter “E” shows the direction of the electric field used to move the nanoparticles through the device. The green balls are spheres with diameters of 100 nanometers whose size restricts them from moving into the shallower regions of the chamber. The coil in the deep end of the chamber (upper right corner) is a single DNA strand that elongates (upper left corner) in the shallow end. (B) Photomicrograph showing fluorescently tagged spherical nanoparticles stopped at the 100-nanometer level of the chamber, the depth that corresponds to their diameter. (C) Photomicrograph of a single DNA strand that is coiled in the deep end of chamber (box at far right) and elongated in the shallow end (box at far left). Larger boxes are closeups showing the fluorescently tagged strands.

Credit: NIST

Abstract:
Researchers at the National Institute of Standards and Technology (NIST) and Cornell University have capitalized on a process for manufacturing integrated circuits at the nanometer (billionth of a meter) level to engineer the first-ever nanoscale fluidic device with complex three-dimensional surfaces. As described in a recent paper in the journal Nanotechnology,* the Lilliputian chamber is a prototype for future tools with custom-designed surfaces to manipulate and measure different types of nanoparticles in solution.

World’s First Nanofluidic Device with Complex 3-D Surfaces Built

Gaithersburg, MD | Posted on April 12th, 2009

Among the potential applications are processing nanoscale materials for manufacturing products such as pharmaceuticals, sorting mixtures of nanoparticles for environmental health and safety investigations, and isolating and confining individual DNA strands for scientific study.

Nanofluidic devices are usually fabricated by etching tiny channels into a glass or silicon wafer with the same "lithographic" procedures used for making integrated circuits. To date, these flat rectangular channels have had simple surfaces with only a few depths. This limits their ability to separate mixtures of nanoparticles with different sizes or study the nanoscale behavior of biomolecules (such as DNA) in detail.

To solve the problem, the researcher team developed a lithographic process to fabricate complex 3-D surfaces. To demonstrate their method, they constructed a nanofluidic chamber with a "staircase" geometry etched into the floor. The "steps" in this staircase—each level giving the device a progressively increasing depth from 10 nanometers (about 6,000 times smaller than the width of a human hair) at the top to 620 nanometers at the bottom—are what give the device its ability to manipulate nanoparticles by size in the same way a coin sorter separates nickels, dimes and quarters.

In these novel experiments, the researchers tested their device with two different solutions: one containing 100-nanometer-diameter polystyrene spheres and the other containing 20-micrometer (millionth of a meter)-length DNA molecules from a virus. In each experiment, the researchers injected the solution into the chamber's deep end and then used electric fields to drive their sample across the device from deeper to shallower levels. Both the spheres and DNA strands were tagged with fluorescent dye so that their movements could be tracked with a microscope.

In the trials using rigid nanoparticles, size exclusion occurred when the region of the chamber where the channels were less than 100 nanometers in depth stayed free of the particles. In the viral DNA trials, the genetic material was coiled in the deeper channels and elongated when forced into the shallower ones. These results demonstrate the utility of the NIST-Cornell 3-D nanofluidic device to perform more complicated nanoscale operations.

Currently, the researchers are working to separate and measure mixtures of different-sized nanoparticles and investigate the behavior of DNA captured in a 3-D nanofluidic environment. For more information and images, see "NIST-Cornell Team Builds World's First Nanofluidic Device with Complex 3-D Surfaces."

* S.M. Stavis, E.A. Strychalski and M.Gaitan. Nanofluidic structures with complex three-dimensional surfaces. Nanotechnology Vol. 20, Issue 16 (online March 31, 2009; in print April 22, 2009).

####

About NIST
Founded in 1901, NIST is a non-regulatory federal agency within the U.S. Department of Commerce. NIST's mission is to promote U.S. innovation and industrial competitiveness by advancing measurement science, standards, and technology in ways that enhance economic security and improve our quality of life.

For more information, please click here

Contacts:
Michael E. Newman

(301) 975-3025

Copyright © NIST

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

“NIST-Cornell Team Builds World’s First Nanofluidic Device with Complex 3-D Surfaces.”

Related News Press

News and information

A nano-roundabout for light December 10th, 2016

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Microfluidics/Nanofluidics

Fabrication of a Miniature Paper-Based Electroosmotic Actuator November 29th, 2016

Researchers use acoustic waves to move fluids at the nanoscale November 15th, 2016

Researchers use temperature to control droplet movement: Method for moving fluids on a surface may find uses in condensers, microfluidics, and de-icing October 14th, 2016

Novel nanoscale detection of real-time DNA amplification holds promise for diagnostics: Research team led by Nagoya University develop a label-free method for detecting DNA amplification in real time based on refractive index changes in diffracted light September 12th, 2016

Chip Technology

A nano-roundabout for light December 10th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Leti IEDM 2016 Paper Clarifies Correlation between Endurance, Window Margin and Retention in RRAM for First Time: Paper Presented at IEDM 2016 Offers Ways to Reconcile High-cycling Requirements and Instability at High Temperatures in Resistive RAM December 6th, 2016

Discoveries

A nano-roundabout for light December 10th, 2016

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Announcements

A nano-roundabout for light December 10th, 2016

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project