Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanopore Sequencing Could Slash DNA Analysis Costs

Abstract:
Over the past 5 years, researchers have been exploring the use of nanoscale pores as nucleic acid sequencing tools. In theory, such pores should generate a unique response characteristic of each of the four nucleotide bases as a piece of DNA moves through the pore.

Nanopore Sequencing Could Slash DNA Analysis Costs

Bethesda, MD | Posted on March 28th, 2009

Now, investigators at Oxford Nanopore Technologies in the United Kingdom have successfully tested a system that can identify a piece of DNA's bases directly as it moves through a modified protein nanopore. With further development, this system could greatly reduce the expensive equipment, chemicals, and lab time needed for current scanning methods, said Gordon Sanghera, Ph.D., Oxford's chief executive.

"You move from days to hours to get the same information, and the equipment required is a lot simpler," Dr. Sanghera said.

Most current DNA sequencers use fluorescent chemical tags that attach to each of the four chemicals that make up a "letter" in the DNA sequence. Sophisticated cameras and software read the tags to identify the genes. In contrast, the system described by these Oxford scientists in the journal Nature Nanotechnology sends DNA one letter at a time through a microscopic, biologically engineered hole, or "nanopore." An electrical current passed across the hole responds differently to each of the four letters in the genetic code, allowing scientists to accurately read each letter.

"This demonstration that you can distinguish among the four bases with a purely electronic signal I think is just an incredible advance," said Jeffery Schloss, Ph.D., director of the National Human Genome Research Institute's sequencing technology program.

Advances in sequencing technology have been swift since the Human Genome Project completed its map of the genetic code in 2003 for $300 million. The current rate hovers around $100,000, although the Federal Government is pledging millions to DNA sequencing research in hopes of achieving a $1,000 genome scan by 2014. Oxford believes its nanopore sequencing could be a contender for the $1,000 scan. However, the company has used nanopores to read only individual DNA letters so far. The company is still working to improve its system to scan entire strands of DNA.
This work is detailed in the paper "Continuous base identification for single-molecule nanopore DNA sequencing." Researchers from the University of Oxford also participated in this study. An abstract of this paper is available at the journal's Web site.

View abstract here www.nature.com/nnano/journal/vaop/ncurrent/abs/nnano.2009.12.html

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Samsung's New Graphene Technology Will Double Life Of Your Lithium-Ion Battery July 1st, 2015

Possible Futures

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Healthcare Nanotechnology (Nanomedicine) Market Size To 2020 June 5th, 2015

Environmental Issues to Hamper Growth of Global Nanocomposites Market June 4th, 2015

Nanomedicine

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th, 2015

Sensors

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Visible Light-Sensitive Photocatalysts Used for Purification of Contaminated Water in Iran June 30th, 2015

Graphene breakthrough as Bosch creates magnetic sensor 100 times more sensitive than silicon equivalent June 28th, 2015

The peaks and valleys of silicon: Team of USC Viterbi School of Engineering Researchers introduce new layered semiconducting materials as silicon alternative June 27th, 2015

Announcements

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Samsung's New Graphene Technology Will Double Life Of Your Lithium-Ion Battery July 1st, 2015

Nanobiotechnology

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

Researchers first to show that Saharan silver ants can control electromagnetic waves over an extremely broad range of the electromagnetic spectrum—findings may lead to biologically inspired coatings for passive radiative cooling of objects June 19th, 2015

Cellulose from wood can be printed in 3-D June 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project