Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Polymer Nanowires Detect Cancer Biomarker

Abstract:
Investigators at the University of California, Riverside, have developed a simple and cost-effective method of building conducting polymer nanowires that can detect a wide range of levels of a cancer biomarker. This work, which was published in the journal Analytical Chemistry, could serve as a model for portable cancer detection equipment suitable for use in a doctor's office.

Polymer Nanowires Detect Cancer Biomarker

Bethesda , MD | Posted on March 28th, 2009

Ashok Mulchandani, Ph.D., led the research team that developed this new device. At its heart lies polypyrrole nanowires connected to a pair of gold electrodes spaced a mere 3 microns apart. The researchers use an applied electric field to move individual nanowires into proper alignment on the gold electrodes. They then coat the nanowires with a material known as EDC that can serve as an attachment point for antibodies and other molecules that bind to specific cancer biomarkers. In the work reported in their recent paper, the investigators attached an antibody that binds to the cancer biomarker CA 125.

When solutions with known concentrations of CA 125 were applied to the biosensor, the device accurately measured concentrations as low as 1 "enzymatic unit" per milliliter (U/mL) of solution to as high as 1,000 U/mL. The maximal normal blood level of CA 125 is considered to be 35 U/mL. The researchers obtained identical results when they tested human blood plasma for CA 125 levels.

The researchers note that their next step will be to create a device capable of measuring a panel of disease markers simultaneously. They also plan to incorporate their biosensor into a microfluidic device that would be suitable for use in a portable disease detection system.

This work is detailed in the paper "Single conducting polymer nanowire chemiresistive label-free immunosensor for cancer biomarker." An abstract of this paper is available at the journal's Web site.

View abstract here pubs.acs.org/doi/abs/10.1021/ac802319f

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Nanomedicine

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

Sensors

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Graphenea opens US branch October 16th, 2014

IRLYNX and CEA-Leti to Streamline New CMOS-based Infrared Sensing Modules Dedicated to Human-activities Characterization October 15th, 2014

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

Nanobiotechnology

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

DNA nano-foundries cast custom-shaped metal nanoparticles: DNA's programmable assembly is leveraged to form precise 3D nanomaterials for disease detection, environmental testing, electronics and beyond October 10th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE