Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Polymer Nanowires Detect Cancer Biomarker

Abstract:
Investigators at the University of California, Riverside, have developed a simple and cost-effective method of building conducting polymer nanowires that can detect a wide range of levels of a cancer biomarker. This work, which was published in the journal Analytical Chemistry, could serve as a model for portable cancer detection equipment suitable for use in a doctor's office.

Polymer Nanowires Detect Cancer Biomarker

Bethesda , MD | Posted on March 28th, 2009

Ashok Mulchandani, Ph.D., led the research team that developed this new device. At its heart lies polypyrrole nanowires connected to a pair of gold electrodes spaced a mere 3 microns apart. The researchers use an applied electric field to move individual nanowires into proper alignment on the gold electrodes. They then coat the nanowires with a material known as EDC that can serve as an attachment point for antibodies and other molecules that bind to specific cancer biomarkers. In the work reported in their recent paper, the investigators attached an antibody that binds to the cancer biomarker CA 125.

When solutions with known concentrations of CA 125 were applied to the biosensor, the device accurately measured concentrations as low as 1 "enzymatic unit" per milliliter (U/mL) of solution to as high as 1,000 U/mL. The maximal normal blood level of CA 125 is considered to be 35 U/mL. The researchers obtained identical results when they tested human blood plasma for CA 125 levels.

The researchers note that their next step will be to create a device capable of measuring a panel of disease markers simultaneously. They also plan to incorporate their biosensor into a microfluidic device that would be suitable for use in a portable disease detection system.

This work is detailed in the paper "Single conducting polymer nanowire chemiresistive label-free immunosensor for cancer biomarker." An abstract of this paper is available at the journal's Web site.

View abstract here pubs.acs.org/doi/abs/10.1021/ac802319f

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Researchers identify structural changes that occur in enveloped viruses before invading host August 21st, 2018

Magnetic antiparticles offer new horizons for information technologies: Computer simulations reveal new behavior of antiskyrmions in gradually increased electric currents August 21st, 2018

Energy-efficient spin current can be controlled by magnetic field and temperature: SCMR effect simplifies the design of fundamental spintronic components August 20th, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

Possible Futures

Researchers identify structural changes that occur in enveloped viruses before invading host August 21st, 2018

Magnetic antiparticles offer new horizons for information technologies: Computer simulations reveal new behavior of antiskyrmions in gradually increased electric currents August 21st, 2018

Energy-efficient spin current can be controlled by magnetic field and temperature: SCMR effect simplifies the design of fundamental spintronic components August 20th, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

Nanomedicine

Researchers identify structural changes that occur in enveloped viruses before invading host August 21st, 2018

Novel nanoparticle-based approach detects and treats oral plaque without drugs August 17th, 2018

Research brief: UMN researchers use green gold to rapidly detect and identify harmful bacteria August 15th, 2018

New technology can detect hundreds of proteins in a single sample: Improvement of barcoding technique offers cost-effective alternative to current technology August 13th, 2018

Sensors

CTI Materials drives nano commercialization with it's patented surfactant free nanoparticle dispersions August 15th, 2018

Optical fibers that can 'feel' the materials around them August 7th, 2018

A molecular switch at the edge of graphene July 27th, 2018

Leti & Partners Launch Pilot Program to Assess New Perception Sensors for Autonomous Vehicles July 5th, 2018

Nanobiotechnology

Researchers identify structural changes that occur in enveloped viruses before invading host August 21st, 2018

Novel nanoparticle-based approach detects and treats oral plaque without drugs August 17th, 2018

Research brief: UMN researchers use green gold to rapidly detect and identify harmful bacteria August 15th, 2018

New technology can detect hundreds of proteins in a single sample: Improvement of barcoding technique offers cost-effective alternative to current technology August 13th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project