Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Cobalt Nanoparticles Boost Imaging Sensitivity and Edge Detection

Abstract:
Magnetic resonance imaging (MRI) can serve as a very sensitive technique for detecting small tumors in the body, but it is not as good at identifying the edges of a tumor.

Cobalt Nanoparticles Boost Imaging Sensitivity and Edge Detection

Bethesda, MD | Posted on March 27th, 2009

Photoacoustic imaging tomography (PAT) is not as sensitive as MRI, but it excels at pinpointing the location of subsurface tissue structures, presumably including the edges of tumors. To take advantage of the best of both of these imaging techniques, a team of investigators led by Fanqing Frank Chen, Ph.D., University of California, San Francisco, has developed a "nanowonton" of cobalt and gold to create an imaging contrast agent for use with both MRI and PAT.

Reporting its work in the Proceedings of the National Academy of Sciences of the United States of America, this team describes how it created the imaging agent by first preparing cobalt nanoparticles and then coating them with a uniform layer of gold. Cobalt nanoparticles are highly effective as MRI contrast enhancing agents, but by themselves, they are not suitable for use in humans. The gold layer not only makes the nanoparticles biocompatible but also adds PAT contrast enhancement as a particle characteristic. The investigators designed the gold coating to have a shape and thickness that maximizes the PAT response to a 700-nm imaging laser.

Imaging experiments with these nanowontons showed that they are detectable at low picomolar levels using MRI. This level of sensitivity would likely be sufficient to spot very small tumors in the body. Additional experiments confirmed that PAT was able to detect particle edges, which is where the PAT signal drops off dramatically. The investigators note that they are now experimenting with other nanoparticle shapes, particularly nanorods, with the goal of increasing MRI sensitivity. The researchers also note that with proper particle design, these hybrid nanomaterials also could serve as photothermal agents that could kill tumors by cooking them to death when energized by light.

This work, which is detailed in the paper "Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles," was supported in part by the National Cancer Institute's Specialized Program of Research Excellence (SPORE). Investigators from the University of California, Los Angeles, Lahore University in Pakistan, Bruker Optics, University of Michigan, and the University of California, Berkeley, also participated in this study. An abstract of this paper is available at the journal's Web site.

View abstract here www.pnas.org/content/106/11/4085

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Imaging

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

News and information

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Announcements

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Nanobiotechnology

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE