Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Synthetic Capsules Made of Natural Building Blocks

Abstract:
Block copolymer vesicles from protein and sugar components

Synthetic Capsules Made of Natural Building Blocks

Bordeaux, France | Posted on March 23rd, 2009

The basis of all life forms are vesicles: membrane-enclosed, liquid-filled "bubbles" made of lipids, proteins, and carbohydrates. Cells, which are separated from the surrounding medium by their cell membrane, are really just big vesicles. Small vesicles play a critical role in the intracellular transport of biomolecules. Synthetic vesicles, such as liposomes and polymersomes, made of lipids and polymers respectively, are used to transport active ingredients in products such as cosmetic or pharmaceutical formulations. They also have potential as microreactors intended to mimic the behavior of living cells. This would be more successful if the vesicles were made of natural components. As reported in the journal Angewandte Chemie, researchers working with Sébastien Lecommandoux and Christophe Schatz at the University of Bordeaux (France) have now attached together blocks of sugar molecule chains (polysaccharides) and protein chains (polypeptides) in a linear fashion. In water, these block copolymers spontaneously form vesicles.

The researchers used dextran, a polymer made of glucose building blocks, and poly(benzyl L-glutamate) (PBLG), a biocompatible polypeptide. By using a series of reactions referred to as "click" chemistry, they attached these molecules to each other blockwise. The advantages of this method are the mild reaction conditions, the nearly quantitative yield, and the fact that other functional side groups on the reactants do not interfere with the reaction.

In this way, the scientists produced block copolymers that combine a polypeptide (protein-like) block and a sugar block. The hydrophobic (water-repellant) polypeptide adopts a helical conformation and in aqueous environments prefers to be side-to-side with those like itself. This results in membrane-like layers that close in on themselves to form spherical vesicles. On both sides of the synthetic membrane, the hydrophilic (water-friendly) dextran chains coil up into a stabilizing "corona". Electron microscope images reveal membranes that are about 21 nm thick surrounding vesicles of a very uniform size (about 45 nm radius).

The researchers would like to use their simple, versatile synthetic strategy to make other synthetic glycopeptides that could be used as model compounds for the exploration of cellular sugar structures (glycomics). The vesicles could also form the basis for a new generation of drug and gene transporters, because their sugar corona binds well to glycoproteins on the surfaces of living cells. The vesicles are also similar to the hulls of viruses and are a first step toward mimicking virus morphology.


Author: Sébastien Lecommandoux, Université de Bordeaux, Pessac (France), recherche.enscpb.fr/lcpo/fr/fichier%20html/perso_lecommandoux-fr.htm

Title: Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

Angewandte Chemie International Edition 2009, 48, No. 14, 2572-2575, doi: 10.1002/anie.200805895


####

Contacts:
Editorial office:

Amy Molnar (US)


Jennifer Beal (UK)


Alina Boey (Asia)

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Chemistry

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

2-faced 2-D material is a first at Rice: Rice University materials scientists create flat sandwich of sulfur, molybdenum and selenium August 14th, 2017

Clarifiying complex chemical processes with quantum computers August 3rd, 2017

Strem Chemicals Surpasses ChemStewards® Requirements: Strem Qualifies for SOCMA’s “Excellence” Ranking August 3rd, 2017

Possible Futures

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Nanomedicine

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Gold shines through properties of nano biosensors: Researchers discover that fluorescence in ligand-protected gold nanoclusters is an intrinsic property of the gold particles themselves August 16th, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Announcements

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project