Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New stretchable electrodes created to study stresses on cardiac cells

Babak Ziaie, a Purdue associate professor of electrical and computer engineering, demonstrates a new "stretchable" electrode created in research with Stanford University to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases. The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer.

Credit: Purdue News Service photo/Andrew Hancock
Babak Ziaie, a Purdue associate professor of electrical and computer engineering, demonstrates a new "stretchable" electrode created in research with Stanford University to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases. The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer. Credit: Purdue News Service photo/Andrew Hancock

Abstract:
Engineers at Purdue and Stanford universities have created stretchable electrodes to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases.

The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer, said Babak Ziaie, a Purdue associate professor of electrical and computer engineering.

New stretchable electrodes created to study stresses on cardiac cells

WEST LAFAYETTE, IN | Posted on January 22nd, 2009

Cell cultures are grown on top of the new "stretchable cell culture platform."

"We designed a simple and cost-effective process for fabricating these stretchable platforms," said Ziaie, who is working with Beth L. Pruitt, an assistant professor of mechanical engineering at Stanford, along with graduate students and other researchers at both universities. "What's special about this technology is that it allows you to electrically stimulate or monitor the cell population using electrodes while you are applying stress to the cells."

Stretching the cell cultures causes mechanical stresses like those exerted on tissues during heart attacks and traumatic brain injuries. The researchers have grown mice cardiac muscle cells on the platform and may grow cell cultures of neurons in future work. Cultures of stem cells also could be tested using the system to determine how mechanical stresses prompt the cells to differentiate into specific types of tissues, Ziaie said.

"You cannot stretch solid metal beyond a few percent because it will break, but we've been able to stretch these liquid platforms more than 40 percent of their original size," Ziaie said.

Findings are detailed in a paper being presented Monday (Jan. 26) during the 22nd IEEE International Conference on Micro Electro Mechanical Systems. The conference, sponsored by the Institute of Electrical and Electronics Engineers, will be in Sorrento, Italy.

"We demonstrated that the platform is biocompatible with human aortic muscle cells and mice heart cells," Ziaie said. "The cells adhered well to the polymer surface during mechanical strain and survived near and on the electrodes after two days of incubation. The platform also maintained its electrical capabilities after being stretched 100 times."

Purdue researchers designed and fabricated the platform at the Birck Nanotechnology Center in Purdue's Discovery Park. Stanford researchers grew cardiac muscle cell cultures on the device and tested the platform.

"We now hold the record for how much you can stretch an electrical conductor," Ziaie said.

The paper was written by Purdue electrical and computer engineering doctoral student Pinghung Wei, Stanford mechanical engineering doctoral student Rebecca Taylor, Purdue physics doctoral student Zhenwen Ding, Stanford mechanical engineering graduate student Gadryn Higgs, Stanford pediatrics postdoctoral research fellow James J. Norman, Pruitt and Ziaie.

####

For more information, please click here

Contacts:
Writer: Emil Venere
(765) 494-4709


Sources: Babak Ziaie
(765) 494-0725


Beth L. Pruitt
(650) 723-4559

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Babak Ziaie

IEEE MEMS 2009 conference

Abstract for the research in this release is available at

Related News Press

News and information

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Nanomedicine

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Discoveries

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Announcements

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Research partnerships

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

Chemistry on the edge: Experiments at Berkeley Lab confirm that structural defects at the periphery are key in catalyst function January 13th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project