Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New stretchable electrodes created to study stresses on cardiac cells

Babak Ziaie, a Purdue associate professor of electrical and computer engineering, demonstrates a new "stretchable" electrode created in research with Stanford University to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases. The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer.

Credit: Purdue News Service photo/Andrew Hancock
Babak Ziaie, a Purdue associate professor of electrical and computer engineering, demonstrates a new "stretchable" electrode created in research with Stanford University to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases. The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer. Credit: Purdue News Service photo/Andrew Hancock

Abstract:
Engineers at Purdue and Stanford universities have created stretchable electrodes to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases.

The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer, said Babak Ziaie, a Purdue associate professor of electrical and computer engineering.

New stretchable electrodes created to study stresses on cardiac cells

WEST LAFAYETTE, IN | Posted on January 22nd, 2009

Cell cultures are grown on top of the new "stretchable cell culture platform."

"We designed a simple and cost-effective process for fabricating these stretchable platforms," said Ziaie, who is working with Beth L. Pruitt, an assistant professor of mechanical engineering at Stanford, along with graduate students and other researchers at both universities. "What's special about this technology is that it allows you to electrically stimulate or monitor the cell population using electrodes while you are applying stress to the cells."

Stretching the cell cultures causes mechanical stresses like those exerted on tissues during heart attacks and traumatic brain injuries. The researchers have grown mice cardiac muscle cells on the platform and may grow cell cultures of neurons in future work. Cultures of stem cells also could be tested using the system to determine how mechanical stresses prompt the cells to differentiate into specific types of tissues, Ziaie said.

"You cannot stretch solid metal beyond a few percent because it will break, but we've been able to stretch these liquid platforms more than 40 percent of their original size," Ziaie said.

Findings are detailed in a paper being presented Monday (Jan. 26) during the 22nd IEEE International Conference on Micro Electro Mechanical Systems. The conference, sponsored by the Institute of Electrical and Electronics Engineers, will be in Sorrento, Italy.

"We demonstrated that the platform is biocompatible with human aortic muscle cells and mice heart cells," Ziaie said. "The cells adhered well to the polymer surface during mechanical strain and survived near and on the electrodes after two days of incubation. The platform also maintained its electrical capabilities after being stretched 100 times."

Purdue researchers designed and fabricated the platform at the Birck Nanotechnology Center in Purdue's Discovery Park. Stanford researchers grew cardiac muscle cell cultures on the device and tested the platform.

"We now hold the record for how much you can stretch an electrical conductor," Ziaie said.

The paper was written by Purdue electrical and computer engineering doctoral student Pinghung Wei, Stanford mechanical engineering doctoral student Rebecca Taylor, Purdue physics doctoral student Zhenwen Ding, Stanford mechanical engineering graduate student Gadryn Higgs, Stanford pediatrics postdoctoral research fellow James J. Norman, Pruitt and Ziaie.

####

For more information, please click here

Contacts:
Writer: Emil Venere
(765) 494-4709


Sources: Babak Ziaie
(765) 494-0725


Beth L. Pruitt
(650) 723-4559

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Babak Ziaie

IEEE MEMS 2009 conference

Abstract for the research in this release is available at

Related News Press

News and information

Leti Field Trials Demonstrate New Multicarrier Waveform for Rural, Maritime Broadband Radio: Field Trial in Orkney Islands Used New Filtered Multicarrier Waveform at 700MHz Band with Flexible Bandwidth Usage (Fragmented and Continuous Spectrum) December 18th, 2017

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

Nanomedicine

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Discoveries

Quantum memory with record-breaking capacity based on laser-cooled atoms December 15th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Announcements

Leti Field Trials Demonstrate New Multicarrier Waveform for Rural, Maritime Broadband Radio: Field Trial in Orkney Islands Used New Filtered Multicarrier Waveform at 700MHz Band with Flexible Bandwidth Usage (Fragmented and Continuous Spectrum) December 18th, 2017

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

Research partnerships

Leti Field Trials Demonstrate New Multicarrier Waveform for Rural, Maritime Broadband Radio: Field Trial in Orkney Islands Used New Filtered Multicarrier Waveform at 700MHz Band with Flexible Bandwidth Usage (Fragmented and Continuous Spectrum) December 18th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Wheat gets boost from purified nanotubes: Rice University toxicity study shows plant growth enhanced by -- but only by -- purified nanotubes December 6th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project