Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Biodegradable Nanoprobe Images New Blood Vessel Growth

Abstract:
Angiogenesis, the growth of new blood vessels, plays a critical role in several chronic human diseases, including metastatic cancer. In fact, several new anticancer therapies are designed to starve tumors by shutting down angiogenesis, but the lack of a good assay for quantifying angiogenesis in the body has hampered the development of effective antiangiogenesis therapies.

Biodegradable Nanoprobe Images New Blood Vessel Growth

Bethesda, MD | Posted on January 17th, 2009

Late fall 2008, researchers at The Siteman Center of Cancer Nanotechnology Excellence described a novel nanoparticle capable of imaging angiogenesis using magnetic resonance imaging (click here to see earlier story). Now, researchers at the University of California, Berkeley, have developed a second type of nanoparticle that can image angiogenesis using positron emission tomography (PET). The investigators, led by Jean Fréchet, Ph.D., describe their new nanoparticle in a paper published in the journal Proceedings of the National Academy of Sciences of the United States of America.

The investigators used a nanoparticle known as a dendrimer, a spherical polymer with multiple chemical functionality built into its structure. This chemical functionality enabled the investigators to incorporate radioactive bromine-76 into the core of the dendrimer and add a targeting agent to the outside of the dendrimer. For a targeting agent, the researchers used cyclic-RGD, a well-studied peptide that binds strongly to the integrin avb3, a protein expressed only on the surface of new blood vessels. The dendrimer itself was designed to degrade in the body once imaging is complete.

Studies using cells grown in culture showed that cells expressing avb3 readily took up the targeted dendrimers, whereas other cells did not. These experiments also showed that binding affinity for the targeted nanoparticle was some fiftyfold higher than for cyclic-RGD alone. This significant boost in binding affinity likely results from a Velcro®-like effect in which multiple cyclic-RGD molecules on the nanoparticle bind simultaneously to multiple avb3 molecules on the surface of target cells. Subsequent studies in mice showed that the targeted dendrimer was able to image sites of angiogenesis with relatively little background from nonspecific binding.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis.”

Related News Press

News and information

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Imaging

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Richards-Kortum elected to American Academy of Arts and Sciences: April 22nd, 2015

Nanomedicine

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Discoveries

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

SEFCU, SUNY Poly CNSE Announce Winning Student-Led Teams in the 6th Annual $500,000 New York Business Plan Competition April 25th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Announcements

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project