Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Artificial Antibody Delivers Nanoparticles to Tumors

Abstract:

Back
Nanotech News


January 2009

Artificial Antibody Delivers Nanoparticles to Tumors

Antibodies that target epidermal growth factor receptor (EGFR) have proven themselves as potent anticancer drugs. Now, a team of investigators led by Shuming Nie, Ph.D., and Lily Yang, Ph.D., both at the Emory University School of Medicine and members of the Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology, is aiming to capitalize on this targeting ability, using a modified anti-EGFR antibody to delivery nanoparticles into tumor cells.

Artificial Antibody Delivers Nanoparticles to Tumors

Bethesda, MD | Posted on January 17th, 2009

Reporting its work in the journal Small, the Emory team describes its use of a so-called single-chain antibody to mimic the tumor-targeting properties of a standard anti-EGFR antibody. Standard antibodies are large biomolecules comprising two pairs of two peptide chains known as heavy and light chains. In part because of their large size, antibodies are difficult to work with and often have difficulty accessing the deeper regions of a solid tumor. To overcome these problems, the investigators built an artificial antibody comprising portions of a single heavy chain and a light chain hooked together. This construct is less than 20% of the size and weight of a full antibody, but it retains the larger molecule's binding abilities for EGFR.

With their artificial antibody in hand, the investigators used it as a tumor-targeting agent for two types of nanoparticles—quantum dots, which can be seen using fluorescence imaging, and iron oxide nanoparticles, which can be imaged using standard magnetic resonance imaging (MRI) instruments. The Emory team attached the targeting agent to the nanoparticles using a novel linking technology they developed for this purpose.

With the two types of antibody-linked nanoparticles in hand, the investigators conducted a series of experiments to determine whether these nanoscale constructs would target tumors and whether tumor cells would take up take the antibody-nanoparticle combos. Indeed, targeted nanoparticles homed in quickly on tumors when injected into tumor-bearing mice, whereas untargeted nanoparticles accumulated primarily in the liver and spleen. The targeted nanoparticles also gained rapid entry into tumor cells, whereas the untargeted nanoparticles did not. The nanoparticles were visible using both fluorescence imaging and MRI.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging.”

Related News Press

News and information

Carbon nanotube optics poised to provide pathway to optical-based quantum cryptography and quantum computing: Researchers are exploring enhanced potential of carbon nanotubes for unique applications June 18th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Squeezing light at the nanoscale: Ultra-confined light could detect harmful molecules June 17th, 2018

Physicists devise method to reveal how light affects materials: The new method adds to the understanding of the fundamental laws governing the interaction of electrons and light June 15th, 2018

Imaging

New optical sensor can determine if molecules are left or right 'handed' June 13th, 2018

Nano-saturn: Supramolecular complex formation: Anthracene macrocycle and C60 fullerene June 8th, 2018

Scientists use photonic chip to make virtual movies of molecular motion June 6th, 2018

From Face Recognition to Phase Recognition: Neural Network Captures Atomic-Scale Rearrangements: Scientists use approach analogous to facial-recognition technology to track atomic-scale rearrangements relevant to phase changes, catalytic reactions, and more May 31st, 2018

Nanomedicine

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Graphene carpets: So neurons communicate better: Research by SISSA reveals that graphene can strengthen neuronal activity, confirming the unique properties of this nanomaterial. The study has been published on Nature Nanotechnology June 13th, 2018

New optical sensor can determine if molecules are left or right 'handed' June 13th, 2018

A nanotech sensor that turns molecular fingerprints into bar codes June 7th, 2018

Discoveries

Carbon nanotube optics poised to provide pathway to optical-based quantum cryptography and quantum computing: Researchers are exploring enhanced potential of carbon nanotubes for unique applications June 18th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Squeezing light at the nanoscale: Ultra-confined light could detect harmful molecules June 17th, 2018

Physicists devise method to reveal how light affects materials: The new method adds to the understanding of the fundamental laws governing the interaction of electrons and light June 15th, 2018

Announcements

Carbon nanotube optics poised to provide pathway to optical-based quantum cryptography and quantum computing: Researchers are exploring enhanced potential of carbon nanotubes for unique applications June 18th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Squeezing light at the nanoscale: Ultra-confined light could detect harmful molecules June 17th, 2018

Physicists devise method to reveal how light affects materials: The new method adds to the understanding of the fundamental laws governing the interaction of electrons and light June 15th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project