Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanotubes Sniff Out Cancer Agents in Living Cells

Abstract:
A multidisciplinary team at the Massachusetts Institute of Technology (MIT) has developed carbon nanotubes that can be used as sensors for cancer drugs and other DNA-damaging agents inside living cells. The sensors, made of carbon nanotubes wrapped in DNA, can detect chemotherapy drugs such as cisplatin as well as environmental toxins and free radicals that damage DNA.

Nanotubes Sniff Out Cancer Agents in Living Cells

Bethesda, MD | Posted on January 17th, 2009

"We've made a sensor that can be placed in living cells, healthy or malignant, and actually detect several different classes of molecules that damage DNA," said Michael Strano, Ph.D., leader of the research team and a member of the MIT-Harvard Center of Cancer Nanotechnology Excellence. Dr. Strano and his colleagues published their work in the journal Nature Nanotechnology.

Such sensors could be used to monitor chemotherapy patients to ensure that drugs are effectively battling tumors. Many chemotherapy drugs are powerful DNA disruptors and can cause serious side effects, so it is important to make sure that the drugs are reaching their intended targets. The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals.

"You can figure out not only where the drugs are, but also whether a drug is active or not," said Daniel Heller, a graduate student in chemical engineering and lead author of the paper.

Using the sensors, researchers can monitor living cells over an extended period of time. The sensor can pinpoint the exact location of molecules inside cells, and for one agent, hydrogen peroxide, it can detect a single molecule.

The new technology takes advantage of the fact that carbon nanotubes fluoresce in near-infrared light, whereas human tissue does not, which makes it easier to see the nanotubes light up. In addition, each nanotube's fluorescence depends strongly on events taking place on the surface of the nanotube, such as when molecules bind to the nanotube surface.

Each nanotube is coated with DNA, which binds to DNA-damaging agents present in the cell. That interaction between DNA and the DNA disruptor changes the intensity and/or wavelength of the fluorescent light emitted by the nanotube. The agents produce different signatures that can be used to identify them. Moreover, the investigators developed signal processing methods that separate the signatures of multiple different molecules binding to the nanotubes.

"We can differentiate between different types of molecules depending on how they interact," Dr. Strano said. He added that future studies will use the new nanotube sensors to study the effects of various antioxidants, such as the compounds in green tea, and learn how to more effectively use toxic chemotherapy drugs.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes.”

Related News Press

News and information

Organometallics welcomes new editor-in-chief: Paul Chirik, Ph.D. July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

Nanotubes/Buckyballs

University of Houston researchers create new method to draw molecules from live cells: Technique using magnetic nanomaterials offers promise for diagnosis, gene therapy July 17th, 2014

3-D nanostructure could benefit nanoelectronics, gas storage: Rice U. researchers predict functional advantages of 3-D boron nitride July 15th, 2014

Researchers discover boron 'buckyball' July 14th, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Nanomedicine

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

SentiMag® Now Available in Australia and New Zealand July 21st, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Iranian Scientists Use Nanosensors to Achieve Best Limit for Early Cancer Diagnosis July 19th, 2014

Sensors

Tiny laser sensor heightens bomb detection sensitivity July 19th, 2014

Iranian Scientists Use Nanosensors to Achieve Best Limit for Early Cancer Diagnosis July 19th, 2014

Rice nanophotonics experts create powerful molecular sensor: Sensor amplifies optical signature of single molecules about 100 billion times July 15th, 2014

University of Illinois researchers demonstrate novel, tunable nanoantennas July 14th, 2014

Discoveries

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

NUS scientists use low cost technique to improve properties and functions of nanomaterials: By 'drawing' micropatterns on nanomaterials using a focused laser beam, scientists could modify properties of nanomaterials for effective applications in photonic and optoelectric applicat July 22nd, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Announcements

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Bruker Awarded Fourth PeakForce Tapping Patent: AFM Mode Uniquely Combines Highest Resolution Imaging and Material Property Mapping July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE