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Home > Press > Preparing an anticancer drug carrier via crystallization of nano-particles

Abstract:
A research team led by Prof. MA Guanghui with the CAS Institute of Processing Engineering has developed a one-pot approach to couple the crystallization of CaCO3 nanoparticles and the in-situ symmetry-breaking assembly of these crystallites into hollow spherical shells under the templating effect of a soluble starch. Their work was published in a recent issue of Journal of American Chemical Society.

Preparing an anticancer drug carrier via crystallization of nano-particles

Beijing, China | Posted on December 24th, 2008

Their further functional studies using HP-a as an anticancer drug carrier demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

The work was supported by the National Natural Science Foundation of China, CAS, and Ministry of Science and Technology, respectively

####

About Chinese Academy of Sciences
CAS strives to build itself into a scientific research base at advanced international level, a base for fostering and bringing up advanced S&T talents, and a base for promoting the development of China's high and new technology industries. By 2010, CAS will have about 80 national institutes noted for their powerful capacities in S&T innovation and sustainable development or with distinctive features; thirty of them will become internationally acknowledged, high-level research institutions, and three to five will be world class.

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Chinese Academy of Sciences

Add: 52 Sanlihe Rd., Beijing China
Postcode: 100864
Tel: 86 10 68597289
Fax: 86 10 68512458

Chief-Editor's Information:
Guo Haiyan
the Editor
Bulletin of Chinese Academy of Sciences
CAS Institute of Policy & Management,
P.O.Box 8712, Beijing 100080, China.

Copyright © Chinese Academy of Sciences

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