Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NJIT professor finds engineering technique to identify disease-causing genes

Abstract:
Scientists believe that complex diseases such as schizophrenia, major depression and cancer are not caused by one, but a multitude of dysfunctional genes. A novel computational biology method developed by a research team led by Ali Abdi, PhD, www.njit.edu/news/2008/2008-367.php, associate professor in NJIT's department of electrical and computer engineering, has found a way to uncover the critical genes responsible for disease development.

NJIT professor finds engineering technique to identify disease-causing genes

Newark, NJ | Posted on October 28th, 2008

The research appeared in "Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways," the current cover article of Science Signaling, a new publication of the American Association for the Advancement of Science, publisher of Science.

"We see our research developing a novel technology holding high promises for finding key molecules that contribute to human diseases and for identifying critical targets in drug development," said Abdi. "The key to success was our collaboration among researchers with different backgrounds in engineering and medical sciences."

The scientists analyzed large cellular molecular networks whose dysfunction contributed to the development of certain complex human disorders. Molecules--genes or proteins—communicate through interconnected pathways via different biochemical interactions, explained Abdi. Through these interactions, molecules propagate regulatory signals. The function of cells in the body is vulnerable to the dysfunction of some molecules within a cell. "In other words," he added, "different diseases may arise from the dysfunction of one or several molecules within an interconnected network system."

To better understand how dysfunctional molecules pass on their problems and which ones are key players, the scientists developed a novel, biologically-driven vulnerability assessment method. This novel algorithm is capable of calculating the vulnerability levels of all molecules in a network. Using a computer, they analyzed the vulnerability of several signaling networks.

"We found few molecules with the highest vulnerability level," said Ali. "Nevertheless, we observed that if each of these molecules failed to function, the entire molecular network would not work." These critical molecules, he said, also held the key to better and more effective treatments. "By understanding their roles and functions better, we would be able to develop more effective treatments for complex disorders with such unknown molecular basis," Abdi said. "Many mental illnesses fall within this category."

Effat Emamian, MD, founder and CEO of Advanced Technologies for Novel Therapeutics, a start-up company in NJIT's business incubator, and Mehdi Tahoori, assistant professor at Northeastern University, contributed to the research.

"In the field of medical research, we face enormous challenges for finding the causes and curative treatments for complex human disorders" said Emamian, whose research focuses on mental disorders. "We believe that complex human disorders, such as cancer, different mental disorders and some neurodegenerative disorders, are not caused by a single gene but rather many. Our most important task is to figure out which genes are critical for disease development and which molecules are the most promising therapeutic targets."

Tahoori noted that it was exciting to see how circuit engineering research can contribute to finding the possible causes and treatments of complex human diseases. "Modeling a problem in a different domain and using tools, methods, and techniques available in the other modeling domain can lead to breakthrough solutions for the original problem," he said. "This is what cross-disciplinary research is all about."

####

About New Jersey Institute of Technology
NJIT, New Jersey's science and technology university, enrolls more than 8,000 students in bachelor's, master's and doctoral degrees in 92 degree programs offered by six colleges: Newark College of Engineering, New Jersey School of Architecture, College of Science and Liberal Arts, School of Management, Albert Dorman Honors College and College of Computing Sciences. NJIT is renowned for expertise in architecture, applied mathematics, wireless communications and networking, solar physics, advanced engineered particulate materials, nanotechnology, neural engineering and eLearning. In 2006, Princeton Review named NJIT among the nation's top 25 campuses for technology and top 150 for best value. U.S. News & World Report's 2007 Annual Guide to America's Best Colleges ranked NJIT in the top tier of national research universities.

For more information, please click here

Contacts:
Sheryl Weinstein

973-596-3436

Copyright © New Jersey Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Canatu Launches CNB In-Mold Film for Transparent Touch on 3D Surfaces –in Cars, Household Appliances, Wearables, Portables November 20th, 2014

Nanomedicine

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

Discoveries

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Announcements

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE