Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > News > More Spring in the Double Helix's Step: DNA proven softer than previously thought

October 19th, 2008

More Spring in the Double Helix's Step: DNA proven softer than previously thought

Abstract:
The DNA's double helix--the sub-microscopic core of our life--has been the subject of intense study and scrutiny for decades.

Observations and measurements at the scale of DNA are tricky. The distance between the rungs in DNA's ladder (or base pairs), for example, was thought to be barely over 3 millionths of a millimeter, or 3.4 (angstroms). And this ladder has been typically assumed to be very rigid.

But now a team of Stanford scientists, supported in part by the National Science Foundation, have used a novel molecular ruler to cast doubts on this picture. Using this molecular ruler, they marked each end of a snippet of DNA with electron-dense gold nanocrystals. These markers scattered X-rays directed at the sample differently than the rest of the molecules, and allowed for a more precise calculation.

The observations led the Stanford team to discover that DNA is much softer than previously thought. Variation--both compression and stretching--was observed.

Story:
Most surprisingly, the team found that if a base pair had compressed, the base pairs in at least the next two turns of the double helix were more likely to be compressed as well.

These observations have important ramifications for biologists looking at proteins binding to DNA, such as transcription factors regulating gene expression. Because this study has shown regions of DNA affecting the behavior of neighboring regions, it could mean that proteins binding to the DNA could communicate across greater molecular distances than previously thought.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Govt.-Legislation/Regulation/Funding/Policy

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

Nagoya physicists resolve long-standing mystery of structure-less transition: Nagoya University-led team of physicists use a synchrotron radiation X-ray source to probe a so-called 'structure-less' transition and develop a new understanding of molecular conductors August 21st, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Discoveries

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Announcements

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project