Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > News > Discovering the secrets of DNA repair

August 19th, 2008

Discovering the secrets of DNA repair

Abstract:
A modified DNA is helping scientists to understand the sophisticated DNA repair mechanisms that allow dormant bacteria to come 'back to life'.

Thomas Carell and Eva Bürckstümmer at the Ludwig Maximilian University of Munich, Germany, have made short DNA strands containing lesions. Carell explains that this is the key to understanding DNA repair. 'So far any study of this enigmatic process has been hampered by a lack of DNA containing this lesion,' he explains.

The lesions are analogues of those triggered when UV light acts on DNA stored in spores such as the Bacillus bacteria spore. In nature, these spores can lie dormant for many years, storing DNA, but then return to life, explains Carell. How spores store DNA and how lesion repair occurs are the questions the German duo would like to answer.

Carell and Bürckstümmer made their DNA strands by synthesising two isomers of a dinucleotide lesion analogue and incorporating them into DNA. They found that one DNA was more stable than the other, suggesting that the natural lesion could have a similar structure to the analogue in the more stable DNA. Carell points out that similar lesion analogues are substrates for the spore DNA repair enzyme so that the new strands could help further studies into the enzyme mechanism.

Source:
rsc.org

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

'Memtransistor' brings world closer to brain-like computing: Combined memristor and transistor can process information and store memory with one device February 22nd, 2018

Nanomedicine

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease February 22nd, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

Discoveries

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

'Memtransistor' brings world closer to brain-like computing: Combined memristor and transistor can process information and store memory with one device February 22nd, 2018

Announcements

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

'Memtransistor' brings world closer to brain-like computing: Combined memristor and transistor can process information and store memory with one device February 22nd, 2018

Nanobiotechnology

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease February 22nd, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project