Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Saliva Can Help Diagnose Heart Attack, Study Shows

Scientists and engineers from The University of Texas at Austin are developing a series of nano-bio-chip sensors to be used for advanced saliva testing. The blue silicon chip is etched to create a series of miniature test tubes where saliva cardiac tests are completed. The round objects in back are microfabricated from sheets of stainless steel, making the systems about 100 times cheaper than the silicon elements. Photo by Glen Simmons.
Scientists and engineers from The University of Texas at Austin are developing a series of nano-bio-chip sensors to be used for advanced saliva testing. The blue silicon chip is etched to create a series of miniature test tubes where saliva cardiac tests are completed. The round objects in back are microfabricated from sheets of stainless steel, making the systems about 100 times cheaper than the silicon elements. Photo by Glen Simmons.

Abstract:
Early diagnosis of a heart attack may now be possible using only a few drops of saliva and a new nano-bio-chip, a multi-institutional team led by researchers at The University of Texas at Austin reported at a recent meeting of the American Association of Dental Research.

Saliva Can Help Diagnose Heart Attack, Study Shows

Austin, TX | Posted on April 17th, 2008

The nano-bio-chip assay could some day be used to analyze a patient's saliva on board an ambulance, at the dentist's office or at a neighborhood drugstore, helping save lives and prevent damage from cardiac disease. The device is the size of a credit card and can produce results in as little as 15 minutes.

"Many heart attack victims, especially women, experience nonspecific symptoms and secure medical help too late after permanent damage to the cardiac tissue has occurred," says John T. McDevitt, principal investigator and designer of the nano-bio-chip. "Our tests promise to dramatically improve the accuracy and speed of cardiac diagnosis."

McDevitt, a professor of chemistry and biochemistry at The University of Texas at Austin, collaborated with scientists and clinicians at the University of Kentucky, University of Louisville, and The University of Texas Health Science Center at San Antonio.

Cardiovascular disease is the leading cause of death in developed countries, including the United States. In 2008, an estimated 770,000 Americans will have a new coronary attack, and about 430,000 will have a recurrent attack.

"There is certainly a strong need for more effective early diagnosis of cardiac disease," says McDevitt.

McDevitt and his co-workers and collaborators took advantage of the recent identification of a number of blood serum proteins that are significant contributors to, and thus indicators of, cardiac disease.

Leveraging microelectronics components and microfabrication developed initially for the electronic industry, the research group developed a series of compact nano-bio-chip sensor devices that are biochemically-programmed to detect sets of these proteins in saliva. They looked at 32 proteins currently used for diagnosis of blood serum in cardiac clinical practice.

The new diagnostic test works like this: A patient spits into a tube and the saliva is then transferred to a credit card-sized lab card that holds the nano-bio-chip. The loaded card is inserted like an ATM card into an analyzer that manipulates the sample and analyses the patient's cardiac status on the spot.

The test can reveal that a patient is currently having a heart attack and that they should receive treatment quickly. It can also tell a patient that they are at high risk of having a future heart attack.

The researchers have currently measured 80 clinical patients and their data shows that the saliva tests were nearly equivalent to more standard tests on blood serum using FDA-approved instruments.

"What's novel here is our ability to measure all such proteins in one setting and to use a noninvasive saliva sample, where low protein levels make such tests difficult even with large and expensive lab instruments," McDevitt says.

The new technology is still in the clinical testing phase, but it is a strong candidate for further commercial development through the Austin, Texas company LabNow, Inc., a start-up venture that licensed the lab-on-a-chip technologies from The University of Texas at Austin. LabNow's first lab-on-a-chip product, now in development, targets HIV immune function testing and can be used in resource poor settings like Africa.

Lead investigators from The University of Texas at Austin are Drs. John McDevitt, Nicolaos Christodoulides and Pierre N. Floriano. The University of Texas Health Science Center at San Antonio lead investigators include Drs. Chih-Ko Yeh and Spencer Redding. Lead investigators at the University of Kentucky are Drs. Craig Miller, Michael J. Novak and Jeff Ebersole. University of Louisville lead investigator is Dr. Denis Kinane.

This research is supported by the National Institute of Dental and Craniofacial Research at the National Institutes of Health.

####

For more information, please click here

Contacts:
Lee Clippard
College of Natural Sciences
512-232-0675


Dr. John McDevitt
512-471-0046


Ann Blackford
859-323-6363 ext. 230

Copyright © University of Texas at Austin

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Lab on a Chip Diagnostics - McDevitt Research Labs UT Austin

Related News Press

News and information

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Nanomedicine

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Discoveries

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Shaping the Future of Nanocrystals: Berkeley Lab Researchers Obtain First Direct Observation of Facet Formation in Nanocubes August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Announcements

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE