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January 23rd, 2008

GMU scientists design nanoparticle for use in early disease detection

Abstract:
Scientists at George Mason University have developed a new technology to detect diseases such as cancer at an earlier stage than with standard testing methods.

They plan to take their innovation into the commercial market this year, followed by widespread distribution in physicians' offices.

Molecules in blood samples also start to degrade very quickly, which can change the biomarkers.

The team has designed smart hydrogel nanoparticles that can be mixed with blood samples. The particles "concentrate, capture, protect and preserve biomarkers," Liotta said.

A team at the university's Center for Applied Proteomics and Molecular Medicine has figured out a way to better identify biomarkers, which can indicate the presence of cancer, as well as cardiovascular and infectious diseases.

"The basic problem in biomarkers is that they're in very low concentration," said Dr. Lance Liotta, co-director of the center. A tiny tumor will produce a tiny amount of biomarkers that will be diluted in a blood sample.

Source:
examiner.com

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