Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanorod-Aptamer Combo Targets Tumors

Abstract:
Aptamers, short stretches of DNA or RNA that can act much like antibodies, have shown promise as targeting agents for selective nanoparticle trafficking to tumors. Their ability to recognize and bind to tumor-specific molecules is undisputed, but the strength with which aptamers bind to their molecular targets is often insufficient to act as an effective targeting agent under clinically relevant conditions.

Nanorod-Aptamer Combo Targets Tumors

Bethesda , MD | Posted on January 16th, 2008

Now, a research team headed by Weihong Tan, Ph.D., at the University of Florida has shown that adding up to 80 aptamers on a single gold/silver nanorod increases the binding ability of this construct by at least 26-fold compared with that of an individual aptamer. Using dye-labeled aptamers, the investigators also were able to produce a cancer-detecting probe whose fluorescent signal is more than 300 times greater than that produced by individual dye-labeled aptamers. This work was published in the journal Analytical Chemistry.

In earlier work, Tan and his colleagues had shown that aptamer-labeled magnetic nanoparticles could be used to separate cancer cells from a mixture of normal and malignant cells. In the current study, he and his colleagues have extended the utility of aptamer targeting by demonstrating that multiple copies of an aptamer, when distributed along the surface of a nanorod, dramatically increase the binding affinity of the nanoscale construct through cooperative binding.

Cooperative binding works in much the same way as the multiple hooks and loops on Velcro®. If the interaction between one hook and loop, or one aptamer and its cellular target, is disrupted, other binding pairs maintain the connection between the two objects, whether it be the nanorod and cancerous cell or the two halves of a Velcro® pair. These findings, the investigators note, suggest that even aptamers that bind weakly, but specifically, to a cancer-related target could still prove useful as nanoparticle targeting agents. Indeed, the use of multiple weak-binding aptamers could reduce nonspecific binding of targeted nanoparticles or nanorods to healthy cells.

This work, which was supported in part by the NCI, is detailed in the paper "Cancer cell targeting using multiple aptamers conjugated on nanorods." An investigator from National Taiwan University in Taipei, Taiwan, also participated in this study. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

News and information

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Nanomedicine

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Discoveries

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Strength of hair inspires new materials for body armor January 18th, 2017

Self-assembling particles brighten future of LED lighting January 18th, 2017

Announcements

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project