Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > News > Integrated gene delivery vectors—Evolution and prospects

January 7th, 2008

Integrated gene delivery vectors—Evolution and prospects

Abstract:
Such safety issues combined with the lack of scalability of viral vectors as vehicles for gene delivery prompted the development of non-viral vectors as gene delivery vehicles. The simplest non-vectors include cationic-polymer-DNA complexes, also known as polyplexes; can be used to deliver DNA into cells. Polyplexes are positively charged complexes of cationic polymers with anionic DNA. Use of cationic materials help condense the negatively charged DNA and reduce its susceptibility to nucleases. In addition, positive charges aid to bind the complex to the negatively charged cell surface and improve the chances of internalisation. Similarly, cationic lipids may be used and the complexes so formed are called lipoplexes. With the advent of nanoscience, the DNA may be complexed with nanoparticles made up of cationic polymers like chitosan or polyethylene imine or cationic lipids like lipofectin. Due to their small size, nanoparticles are deemed to be more efficacious than the simple complexes. Cationic liposomes, owing to their typical bi-layer structure, have also improved the gene delivery efficacy. Liposomes remain one of the most worked upon vehicles from DNA delivery. Many cationic materials are known to cause inflammatory responses and efficacy remains moderate. In spite of these drawbacks, the major achievement of this generation of gene delivery vehicles was of increasing the possible size of the gene they could transfer. While, the highest possible gene size that can be delivered by a virus is eight kda, that with a non-viral vector is at least 50 kda.

Source:
expresspharmaonline.com

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Multi-million pound project to use nanotechnology to improve safety September 4th, 2015

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Tongfang Global and QD Vision Partner to Bring Wide Color Gamut to Global Television Lines: Color IQTM quantum dots help boost company’s focus on superior color reproduction September 3rd, 2015

QEOS and GLOBALFOUNDRIES to Offer Industry’s First CMOS Platform for MillimeterWave Markets: GLOBALSOLUTIONSSM Partnership will enable next-generation wireless technologies for applications in IoT, 5G and automotive September 3rd, 2015

Nanomedicine

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Making nanowires from protein and DNA September 3rd, 2015

Reversible Writing with Light: Self-assembling nanoparticles take their cues from their surroundings September 3rd, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Announcements

Multi-million pound project to use nanotechnology to improve safety September 4th, 2015

Magnetic wormhole connecting 2 regions of space created for the first time: The device could have applications in medicine, opening up ways to make MRIs more comfortable for patients September 4th, 2015

Making nanowires from protein and DNA September 3rd, 2015

Making fuel from light: Argonne research sheds light on photosynthesis and creation of solar fuel September 3rd, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic