Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Building Tumor Balls for Better Drug Discovery

Abstract:
Over the past few years, researchers have found that small, spherical conglomerations of tumor cells are superior to individual cells for predicting the response of malignant cells to a variety of anticancer treatments. Now, researchers at the University of California, Berkeley, have developed a microfluidics device that can form tumor spheroids in a large-scale, reproducible manner amenable to high-throughput drug screening protocols. This work is reported in the journal Biomedical Microdevices.

Building Tumor Balls for Better Drug Discovery

Bethesda , MD | Posted on December 5th, 2007

To trap a reproducible number of cells in an environment that causes the cells to adhere to one another in discrete structures (the tumor spheroid), Luke Lee, Ph.D., and colleagues designed a microfluidics device that uses the properties of fluid flow at the nanoscale to capture cells within a U-shaped structure. Once trapped, the cells continue receiving nutrients and oxygen—or added drug molecules—as the fluid passes through a tiny perfusion channel sounding the larger U-shaped structure, in much the same way that small tumors receive nutrients as they leak from surrounding blood vessels.

The researchers are able to create as many as 7,500 traps per square centimeter, each of which can hold between 9 and 11 cells. Research by other investigators has shown that tumor spheroids of this size, though difficult to make, have higher resistance to drug than do monolayers of cells. Once trapped, the cells begin to adhere to one another, forming what resembles a small mass of cells, rather than a collection of discrete cells. These small masses may accurately represent tumors early in their development. The researchers note that they can alter the size of the U-shaped traps to produce larger spheroids.

This work is detailed in the paper "Microfluidic self-assembly of tumor spheroids for anticancer drug discovery." An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

Nanomedicine

Nanomedicine shines light on combined force of nanomedicine and regenerative medicine March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Wrapping carbon nanotubes in polymers enhances their performance: Scientists at Japan's Kyushu University say polymer-wrapped carbon nanotubes hold much promise in biotechnology and energy applications March 30th, 2015

Discoveries

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

From tobacco to cyberwood March 31st, 2015

Announcements

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE