Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > HHMI Student Profile: Alfredo Celedon

Alfredo Celedon, HHMI NanoBioMed graduate student. Credit: INBT / JHU
Alfredo Celedon, HHMI NanoBioMed graduate student. Credit: INBT / JHU

Abstract:
Nanoparticless open up enormous possibilities for scientists and engineers to study biomolecules, says Alfredo Celedon, a NanoBioMed graduate (pre-doctoral) trainee at the Johns Hopkins University Institute for NanoBioTechnology (INBT).

HHMI Student Profile: Alfredo Celedon

Baltimore, MD | Posted on November 13th, 2007

"The ability to tailor magnetic nanoparticles, connect them to a biomolecule, and use the magnetic nanoparticle to manipulate the molecule is a very powerful concept. It will allow us to study the way different enzymes work, and it may even allow us to use them in new ways," Celedon says. "Proteins are perfect nanomachines, so it would be great to find ways to take advantage of their mechanisms."

The molecule of most interest to Celedon is chromatin, the complex of histone proteins and DNA that make up chromosomes in the nuclei of eukaryotic cells. Celedon is studying the mechanical properties of chromatin by observing chromatin condensation under different biologically relevant conditions.

"If you modify the histones, you change the way the chromatin behaves," Celedon says. "When the chromatin condenses, the structure is tightly held, and there is no access to the DNA. If the chromatin is less condensed, the histones are more loosely held, and access to the DNA is permitted. Cells control gene expression in this way.''

Using nanoparticles and magnetic tweezers, Celedon has been able to exert forces on the chromatin fiber to study its response. He hopes these experiments will shed light on the generally held hypothesis that there is a "histone code" that guides interactions between enzymes and DNA.

Modified histones are prepared in the lab of INBT affiliate Greg Bowman, assistant professor of biophysics at the Krieger School of Arts and Sciences. Magnetic nanoparticles are fabricated in the lab of Peter Searson, professor of materials science and engineering and director of INBT. Experiments using the magnetic tweezers experiments are conducted under an inverted optical microscope in the INBT's laboratory located in the Whiting School of Engineering. Celedon's advisors include INBT affiliate Sean Sun, assistant professor of mechanical engineering, and Denis Wirtz, professor of chemical and biomolecular engineering and INBT's associate director.

"I had previously attempted to model these concepts theoretically," Celedon says. "Through the guidance of my advisors and INBT, we have developed a way to test these

####

About Institute for NanoBioTechnology
The Institute for NanoBioTechnology at Johns Hopkins University will revolutionize health care by bringing together internationally renowned expertise in medicine, engineering, the sciences, and public health to create new knowledge and groundbreaking technologies.

INBT programs in research, education, outreach, and technology transfer are designed to foster the next wave of nanobiotechnology innovation.

Approximately 150 faculty are affiliated with INBT and are also members of the following Johns Hopkins institutions: Krieger School of Arts and Sciences, Whiting School of Engineering, School of Medicine, Bloomberg School of Public Health, and Applied Physics Laboratory.

For more information, please click here

Contacts:
* Institute for NanoBioTechnology
214 Maryland Hall
3400 North Charles Street
Baltimore, MD 21218

* Email:
* Phone: (410) 516-3423
* Fax: (410) 516-2355

Copyright © Institute for NanoBioTechnology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Academic/Education

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

SUNY POLY CNSE to Host First Ever Northeast Semi Supply Conference (NESCO) Conference Will Connect New and Emerging Innovators in the Northeastern US and Canada with Industry Leaders and Strategic Investors to Discuss Future Growth Opportunities in NYS March 25th, 2015

FEI Joins University of Ulm and CEOS on SALVE Project Research Collaboration: The Sub-Ångström Low Voltage Electron (SALVE) microscope should improve contrast and reduce damage on bio-molecules and two-dimensional nanomaterials, such as graphene March 18th, 2015

SUNY Poly CNSE, Known One Day a Year as SUNY PI CNSE, and Tech Valley High School Celebrate Pi Day: More than one hundred students enjoy pizza ‘pi’ as they take part in fun, pi-themed activities meant to share the excitement of mathematics and science in anticipation of March 14 March 14th, 2015

Announcements

Industrial Nanotech, Inc. Announces Next Large Order from the Oil and Gas Industry March 26th, 2015

Quantum compute this -- WSU mathematicians build code to take on toughest of cyber attacks: Revamped knapsack code offers online security for the future March 26th, 2015

Thousands of atoms entangled with a single photon: Result could make atomic clocks more accurate March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE