Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New "longboat delivery system" could mean more potent anti-cancer drugs

Abstract:
Scientists are reporting development of carbon nanotubes as a "longboat delivery system" that shows potential for addressing shortcomings that have hindered development of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society, a weekly publication.

New "longboat delivery system" could mean more potent anti-cancer drugs

Cambridge, MA and Stanford, CA | Posted on June 27th, 2007

The Massachusetts Institute of Technology's Stephen J. Lippard and Stanford University's Hongjie Dai and colleagues note that efforts to produce such molecules have been hindered because the required form of platinum loses activity in the body and becomes ineffective before reaching the tumor. Their solution was to develop a carbon nanotube delivery system, ultimately for shuttling platinum compounds safely through the body's biochemical obstacle course and into the tumor. Once inside the tumor cell, the compounds convert from an inactive form into an active anti-cancer drug.

The chemistry involves attaching platinum compounds to single wall carbon nanotubes (SWNTs), one-atom thick sheets of graphite rolled up into a cylinder with a diameter about 50,000 times smaller than the width of a human hair. The SWNTs act as efficient transporters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug. In one experiment with cultured cells, the SWNTs produced platinum levels inside the cells 6-8 times higher than those for the platinum unit administered in the traditional way. The longboat SWNTs have the potential to carry other passengers to and into the cancer cell, as demonstrated by the co- delivery of platinum and a fluorescent dye to the cancer cell, which in the future will include tumor-targeting components.

####

About Journal of the American Chemical Society
The Publications Division of the American Chemical Society provides the worldwide scientific community with a comprehensive collection of the most cited peer-reviewed journals in the chemical and related sciences. ACS Publications offers 35 prestigious journals in addition to its weekly newsmagazine covering the chemical enterprise, Chemical & Engineering News. With the ACS Journal Archives, ACS Publications provides searchable access to over 130 years of original research in chemistry, including more than 750,000 articles contained in 3 million plus pages of chemistry findings, dating back to the introduction of the Journal of the American Chemical Society in 1879.

For more information, please click here

Contacts:
Stephen J. Lippard, Ph.D.
Massachusetts Institute of Technology
Cambridge, MA 02139
Phone: 617-253-1892
Fax: 617-258-8150


Hongjie Dai, Ph.D.
Stanford University
Stanford, CA 94305
Phone: 650-723-4518
Fax: 650-725-0259

Copyright © Journal of the American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

"Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum (V) Anticancer Drug Design"(PDF)

Related News Press

Nanotubes/Buckyballs

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

Elsevier Publishes New Content on Graphene and Materials Science: Books Discuss Properties and Emerging Applications of Carbon Nanotubes, Graphene and Nanomaterials September 25th, 2014

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Nanomedicine

Arrowhead Expands Management Team with Appointment of Susan Boynton as Vice President Global Regulatory Affairs October 1st, 2014

Nanobotmodels present metastasis and angiogenesis medical animation October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Discoveries

Breakthrough in ALD-graphene by Picosun technology October 1st, 2014

Novel approach to magnetic measurements atom-by-atom October 1st, 2014

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Announcements

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Graphene chips are close to significant commercialization October 1st, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE