Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > New "longboat delivery system" could mean more potent anti-cancer drugs

Abstract:
Scientists are reporting development of carbon nanotubes as a "longboat delivery system" that shows potential for addressing shortcomings that have hindered development of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society, a weekly publication.

New "longboat delivery system" could mean more potent anti-cancer drugs

Cambridge, MA and Stanford, CA | Posted on June 27th, 2007

The Massachusetts Institute of Technology's Stephen J. Lippard and Stanford University's Hongjie Dai and colleagues note that efforts to produce such molecules have been hindered because the required form of platinum loses activity in the body and becomes ineffective before reaching the tumor. Their solution was to develop a carbon nanotube delivery system, ultimately for shuttling platinum compounds safely through the body's biochemical obstacle course and into the tumor. Once inside the tumor cell, the compounds convert from an inactive form into an active anti-cancer drug.

The chemistry involves attaching platinum compounds to single wall carbon nanotubes (SWNTs), one-atom thick sheets of graphite rolled up into a cylinder with a diameter about 50,000 times smaller than the width of a human hair. The SWNTs act as efficient transporters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug. In one experiment with cultured cells, the SWNTs produced platinum levels inside the cells 6-8 times higher than those for the platinum unit administered in the traditional way. The longboat SWNTs have the potential to carry other passengers to and into the cancer cell, as demonstrated by the co- delivery of platinum and a fluorescent dye to the cancer cell, which in the future will include tumor-targeting components.

####

About Journal of the American Chemical Society
The Publications Division of the American Chemical Society provides the worldwide scientific community with a comprehensive collection of the most cited peer-reviewed journals in the chemical and related sciences. ACS Publications offers 35 prestigious journals in addition to its weekly newsmagazine covering the chemical enterprise, Chemical & Engineering News. With the ACS Journal Archives, ACS Publications provides searchable access to over 130 years of original research in chemistry, including more than 750,000 articles contained in 3 million plus pages of chemistry findings, dating back to the introduction of the Journal of the American Chemical Society in 1879.

For more information, please click here

Contacts:
Stephen J. Lippard, Ph.D.
Massachusetts Institute of Technology
Cambridge, MA 02139
Phone: 617-253-1892
Fax: 617-258-8150


Hongjie Dai, Ph.D.
Stanford University
Stanford, CA 94305
Phone: 650-723-4518
Fax: 650-725-0259

Copyright © Journal of the American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

"Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum (V) Anticancer Drug Design"(PDF)

Related News Press

Nanotubes/Buckyballs/Fullerenes/Nanorods

Nano bulb lights novel path: Rice University engineers create tunable, nanoscale, incandescent light source September 20th, 2019

The future of materials with graphene nanotubes starts in Japan September 19th, 2019

MIT engineers develop 'blackest black' material to date: Made from carbon nanotubes, the new coating is 10 times darker than other very black materials September 13th, 2019

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges August 14th, 2019

Nanomedicine

Tiny bubbles in our body could fight cancer better than chemo September 18th, 2019

Keystone Nano Announces FDA Approval of Investigational New Drug Application for Ceraxa for the Treatment of Acute Myeloid Leukemia September 18th, 2019

Inspired by natural signals in living cells, researchers design artificial gas detector: Tiny box puts itself together and glows September 13th, 2019

New health monitors are flexible, transparent and graphene enabled September 13th, 2019

Discoveries

Nano bulb lights novel path: Rice University engineers create tunable, nanoscale, incandescent light source September 20th, 2019

Tiny bubbles in our body could fight cancer better than chemo September 18th, 2019

Uncovering the hidden “noise” that can kill qubits: New detection tool could be used to make quantum computers robust against unwanted environmental disturbances September 17th, 2019

Scientists create a nanomaterial that is both twisted and untwisted at the same time: The material developed at University of Bath allows for incredibly sensitive detection of the direction molecules twist September 13th, 2019

Announcements

Nano bulb lights novel path: Rice University engineers create tunable, nanoscale, incandescent light source September 20th, 2019

The future of materials with graphene nanotubes starts in Japan September 19th, 2019

Tiny bubbles in our body could fight cancer better than chemo September 18th, 2019

Keystone Nano Announces FDA Approval of Investigational New Drug Application for Ceraxa for the Treatment of Acute Myeloid Leukemia September 18th, 2019

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project