Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New "longboat delivery system" could mean more potent anti-cancer drugs

Abstract:
Scientists are reporting development of carbon nanotubes as a "longboat delivery system" that shows potential for addressing shortcomings that have hindered development of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society, a weekly publication.

New "longboat delivery system" could mean more potent anti-cancer drugs

Cambridge, MA and Stanford, CA | Posted on June 27th, 2007

The Massachusetts Institute of Technology's Stephen J. Lippard and Stanford University's Hongjie Dai and colleagues note that efforts to produce such molecules have been hindered because the required form of platinum loses activity in the body and becomes ineffective before reaching the tumor. Their solution was to develop a carbon nanotube delivery system, ultimately for shuttling platinum compounds safely through the body's biochemical obstacle course and into the tumor. Once inside the tumor cell, the compounds convert from an inactive form into an active anti-cancer drug.

The chemistry involves attaching platinum compounds to single wall carbon nanotubes (SWNTs), one-atom thick sheets of graphite rolled up into a cylinder with a diameter about 50,000 times smaller than the width of a human hair. The SWNTs act as efficient transporters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug. In one experiment with cultured cells, the SWNTs produced platinum levels inside the cells 6-8 times higher than those for the platinum unit administered in the traditional way. The longboat SWNTs have the potential to carry other passengers to and into the cancer cell, as demonstrated by the co- delivery of platinum and a fluorescent dye to the cancer cell, which in the future will include tumor-targeting components.

####

About Journal of the American Chemical Society
The Publications Division of the American Chemical Society provides the worldwide scientific community with a comprehensive collection of the most cited peer-reviewed journals in the chemical and related sciences. ACS Publications offers 35 prestigious journals in addition to its weekly newsmagazine covering the chemical enterprise, Chemical & Engineering News. With the ACS Journal Archives, ACS Publications provides searchable access to over 130 years of original research in chemistry, including more than 750,000 articles contained in 3 million plus pages of chemistry findings, dating back to the introduction of the Journal of the American Chemical Society in 1879.

For more information, please click here

Contacts:
Stephen J. Lippard, Ph.D.
Massachusetts Institute of Technology
Cambridge, MA 02139
Phone: 617-253-1892
Fax: 617-258-8150


Hongjie Dai, Ph.D.
Stanford University
Stanford, CA 94305
Phone: 650-723-4518
Fax: 650-725-0259

Copyright © Journal of the American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

"Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum (V) Anticancer Drug Design"(PDF)

Related News Press

Nanotubes/Buckyballs/Fullerenes/Nanorods

Scientists make transparent materials absorb light December 1st, 2017

Researchers advance technique to detect ovarian cancer: Rice, MD Anderson use fluorescent carbon nanotube probes to achieve first in vivo success November 30th, 2017

NanoSummit in Luxembourg: single wall carbon nanotubes have entered our lives as we approach a nanoaugmented future November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Nanomedicine

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

Discoveries

UCLA chemists synthesize narrow ribbons of graphene using only light and heat: Tiny structures could be next-generation solution for smaller electronic devices December 8th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Wheat gets boost from purified nanotubes: Rice University toxicity study shows plant growth enhanced by -- but only by -- purified nanotubes December 6th, 2017

Announcements

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project