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Home > Press > Arrowhead subsidiary, Calando Pharmaceuticals publishes study on targeted systemic delivery of of siRNA

Non-Human Primate Study First to Use Multiple, Systemic Dosing of siRNA

Arrowhead subsidiary, Calando Pharmaceuticals publishes study on targeted systemic delivery of of siRNA

PASADENA, CA | Posted on March 20th, 2007

Arrowhead Research Corporation
(NASDAQ: ARWR) announced today that majority-owned subsidiary Calando
Pharmaceuticals has published results in the Proceedings of the
National Academy of Sciences (PNAS) of the first non-human primate
study to use multiple, systemic dosing with Calando's lead siRNA
therapeutic candidate.

Calando is using its proprietary technologies in targeted polymeric
delivery systems and siRNA design to create new, targeted siRNA
therapeutics. Its lead anti-cancer therapeutic candidate contains a
linear cyclodextrin polymer, the siRNA, and a targeting agent. The
formulation self assembles into nanoparticles that protect the siRNA
from nuclease degradation in serum. One important result of the study
was the lack of a significant immune response to the siRNA,
demonstrating that the formulation is well tolerated at doses much
higher than those previously shown to have anti-cancer effects.
Calando is expecting to enter clinical trials with this formulation
later this year.

Further information about Calando and the study can be found at .


About Arrowhead Research Corporation
Arrowhead Research Corporation ( ) is a
publicly-traded nanotechnology company commercializing new
technologies in the areas of life sciences, electronics, and energy.
Arrowhead is building value for shareholders through the progress of
majority owned subsidiaries founded on nanotechnologies originally
developed at universities. The company works closely with
universities to source early stage deals and to generate rights to
intellectual property covering promising new nanotechnologies.
Currently, Arrowhead has four subsidiaries commercializing nanotech
products and applications, including anti-cancer drugs, RNAi
therapeutics, carbon-based electronics and compound semiconductor

About Calando Pharmaceuticals Inc.

Calando Pharmaceuticals Inc. ( )
(, a majority owned subsidiary of Arrowhead
Research Corporation (NASDAQ: ARWR), is using its proprietary
technologies in targeted polymeric delivery systems and siRNA design
to design and create new, targeted siRNA therapeutics. The company is
pursuing this goal through its internal research and development and
also through collaborations and partnerships with pharmaceutical and
biotechnology companies.

Calando Technology

Calando's cyclodextrin-containing polymers form the foundation for
its two-part siRNA delivery system. The first component is a linear,
cyclodextrin-containing polycation that, when mixed with small
interfering RNA (siRNA), binds to the anionic "backbone" of the
siRNA. The polymer and siRNA self-assemble into nanoparticles of
approximately 50-80 nm diameter that fully protect the siRNA from
nuclease degradation in serum. The siRNA delivery system has been
designed to allow for intravenous injection. Upon delivery to the
target cell, the targeting ligand binds to membrane receptors on the
cell surface and the RNA-containing nanoparticle is taken into the
cell by endocytosis. There, chemistry built into the polymer
functions to unpackage the siRNA from the delivery vehicle. In
addition to targeting tumors, the targeting of liver cells has also
been accomplished in vivo.

Safe Harbor Statement under the Private Securities Litigation Reform
Act of 1995

This news release contains forward-looking statements within the
meaning ofthe "safe harbor" provisions of the Private Securities
Litigation Reform Actof 1995. These statements are based upon our
current expectations and speak onlyas of the date hereof. Our actual
results may differ materially and adversely from those expressed in
any forward-looking statements as a result of various factorsand
uncertainties, including the recent economic slowdown affecting
technology companies, the future success of our scientific studies,
our ability to successfully develop products, rapid technological
change in our markets, changes in demand for our future products,
legislative, regulatory and competitive developments and general
economic conditions. Our Annual Report on Form 10-K and 10-K/A,
recent and forthcoming Quarterly Reports on Form 10-Q and 10-Q/A,
recent Current Reports on Forms 8-K and 8-K/A, our Registration
Statement on Form S-3, and other SEC filingsdiscuss some of the
important risk factors that may affect our business, results of
operations and financial condition. We undertake no obligation to
revise or update publicly any forward-looking statements for any

For more information, please click here

Virginia Dadey; Vice President, Investor Relations

John G. Petrovich

Copyright © Arrowhead Research Corporation

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